| Name | PARK 2 |
|---|---|
| Synonyms | AR JP; LPRS 2; LPRS2; PARK 2; PARK2; PDJ; PRKN; Parkin… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16375772 | Perez FA, Curtis WR, Palmiter RD: Parkin-deficient mice are not more sensitive to or methamphetamine neurotoxicity. BMC Neurosci. 2005 Dec 24;6:71. Nevertheless, Parkin-deficient mice could be more sensitive to other neurotoxins, such as rotenone or MPTP, which have different mechanisms of action; therefore, identifying conditions that precipitate parkinsonism specifically in Parkin-deficient mice would increase the utility of this model and could provide insight into the mechanism of AR-JP. |
82(1,1,1,2) | Details |
| 16573651 | Casarejos MJ, Menendez J, Solano RM, Rodriguez-Navarro JA, Garcia de Yebenes J, Mena MA: Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline. J Neurochem. 2006 May;97(4):934-46. Epub 2006 Mar 29. Mutations of the Park-2 gene are the most frequent cause of familial parkinsonism and parkin knockout (PK-KO) mice have abnormalities that resemble the clinical syndrome. |
2(0,0,0,2) | Details |
| 12690660 | Broussolle E, Thobois S: [Genetics and environmental factors of Parkinson disease] . Rev Neurol. 2002 Dec;158 Spec no 1:S11-23. However, alpha-synuclein gene mutations are rare as opposed to parkin gene mutations (PARK 2), which are frequently found in autosomal recessive and sporadic young onset Parkinson's disease patients. Several chemical products used in herbicides and pesticides are similar structurally to MPTP, including paraquat, diquat and rotenone. |
1(0,0,0,1) | Details |
| 12690311 | Broussolle E, Thobois S: [Genetic and environmental factors of Parkinson's disease] . Rev Neurol. 2002;158(122):11-23. However, alpha-synuclein gene mutations are rare as opposed to parkin gene mutations (PARK 2), which are frequently found in autosomal recessive and sporadic young onset Parkinson's disease patients. Several chemical products used in herbicides and pesticides are similar structurally to MPTP, including paraquat, diquat and rotenone. |
1(0,0,0,1) | Details |