| Name | CYP19 |
|---|---|
| Synonyms | ARO; Microsomal monooxygenase; Flavoprotein linked monooxygenase; ARO 1; ARO1; Aromatase; Aromatase cytochrome P450; CPV 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15212809 | Nakagawa Y, Nakajima K, Suzuki T: Chlorpropham induces mitochondrial dysfunction in rat hepatocytes. . Toxicology. 2004 Aug 5;200(2-3):123-33. The addition of SKF-525A (50 microM), an inhibitor of microsomal monooxygenase, enhanced the CIPC (0.5 mM)-induced cytotoxicity accompanied by loss of ATP and 4OH-CIPC and inhibited the decrease in the concentration of the parent compound. On the other hand, the exposure of isolated hepatic mitochondria to CIPC reduced State 3 respiration with a FAD-linked substrate plus rotenone) and/or with a NAD+ -linked substrate plus whereas State 3 respiration with plus tetramethyl-p-phenylendiamine (cytochrome oxidase-linked respiration) was not affected markedly by CIPC. |
1(0,0,0,1) | Details |
| 15319488 | Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M: Induction and inhibition of aromatase (CYP19) activity by natural and synthetic compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70-9. Epub 2004 Aug 19. The natural derivative rotenone (IC (50) 0.3 microM) was the most potent aromatase inhibitor tested. |
2(0,0,0,2) | Details |