Protein Information

Name cyclin E
Synonyms CCNE; CCNE 1; CCNE1; Cyclin E; Cyclin E1; Cyclin Es; Cyclin Et; G1/S specific cyclin E1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
12460790 Murillo G, Salti GI, Kosmeder JW 2nd, Pezzuto JM, Mehta RG: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. Eur J Cancer. 2002 Dec;38(18):2446-54.


Investigations of G1/S regulatory proteins by Western blot analyses showed an upregulation of p27, and decreased expression levels of cyclin E and CDK4.
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17343987 Alvira D, Tajes M, Verdaguer E, de Arriba SG, Allgaier C, Matute C, Trullas R, Jimenez A, Pallas M, Camins A: Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons. Neuroscience. 2007 Apr 25;146(1):350-65. Epub 2007 Mar 7.


We show a distinct increase in the expression of the cell cycle proteins cyclin D, cyclin E, cdk2, cdk4 and the transcription factor E2F-1 following a MPP+ treatment of CGNs.
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