Protein Information

Name c fos
Synonyms Cellular oncogene fos; FBJ murine osteosarcoma viral (v fos) oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; Oncogene FOS; Proto oncogene protein c fos; c Fos…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19900598 Kwak HB, Lee BK, Oh J, Yeon JT, Choi SW, Cho HJ, Lee MS, Kim JJ, Bae JM, Kim SH, Kim HS: Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression. Bone. 2010 Mar;46(3):724-31. Epub 2009 Nov 6.
93(0,3,3,3) Details
9270009 Gerhauser C, Lee SK, Kosmeder JW, Moriarty RM, Hamel E, Mehta RG, Moon RC, Pezzuto JM: Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res. 1997 Aug 15;57(16):3429-35.

Using cultured mouse epidermal 308 cells, the steady-state levels of both 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC mRNA and c-fos were decreased by treatment with deguelin.
These results suggest that antimicrotubule effects, as mediated by rotenone, for example, are not responsible for inhibitory activity facilitated by deguelin.
1(0,0,0,1) Details
17442543 Tan QR, Wang XZ, Wang CY, Liu XJ, Chen YC, Wang HH, Zhang RG, Zhen XC, Tong Y, Zhang ZJ: Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells. Eur Neuropsychopharmacol. 2007 Dec;17(12):768-73. Epub 2007 Apr 17.

We also determined whether there were differential effects of RIP and HAL on the expression of brain-derived neurotrophic factor (BDNF), signal transducers and activators of transcription-3 (STAT-3), and the immediate early gene c-fos, as well as intracellular levels of calcium.
1(0,0,0,1) Details
16344601 French SW: The pathogenesis and significance of the urinary alcohol cycle in rats fed ethanol intragastrically. Alcohol Clin Exp Res. 2005 Nov;29(11 Suppl):158S-161S.

When complex I (NADH dehydrogenase) of the mitochondrial electron transport chain is inhibited by feeding rotenone, the cycle is totally eliminated and blood alcohol levels remain constant at 200 mg/%.
Genes such as c-fos and CTGF are increased in expression.
1(0,0,0,1) Details