| Name | PTEN |
|---|---|
| Synonyms | BZS; MHAM; MMAC 1; MMAC1; Mutated in multiple advanced cancers 1; PTEN; PTEN 1; PTEN1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19076450 | Knott AB, Bossy-Wetzel E: Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Ann N Y Acad Sci. 2008 Dec;1147:283-92. Rotenone, a pesticide and inducer of PD symptoms, and amyloid-beta peptide, which is causally linked to Alzheimer's disease, initiate mitochondrial fission. In addition, recent findings report increased mitochondrial fission in Parkinson's disease (PD) models and induction of mitochondrial fission by two proteins, PTEN-induced kinase 1 and parkin, which are mutant in familial forms of PD. |
1(0,0,0,1) | Details |
| 20171192 | Um JW, Park HJ, Song J, Jeon I, Lee G, Lee PH, Chung KC: Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochem Biophys Res Commun. 2010 Mar 19;393(4):824-8. Epub 2010 Feb 18. Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) or parkin have been linked to early-onset autosomal recessive forms of familial PD. Consistent with our previous findings from parkin knockout mice, rat models of PD -, rotenone-, or MG132-induced PD) were also associated with an increase in soluble and insoluble PINK1 levels as well as enhanced formation of parkin aggregates. |
1(0,0,0,1) | Details |
| 19492085 | Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Minguez A, Cookson MR: Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One. 2009 May 27;4(5):e5701. PTEN-induced novel kinase 1 (PINK1) mutations are associated with autosomal recessive parkinsonism. We also show that wild-type PINK1, but not recessive mutant or kinase dead versions, protects against rotenone-induced mitochondrial fragmentation whereas PINK1 deficient cells show lower mitochondrial connectivity. |
1(0,0,0,1) | Details |
| 16226715 | Deng H, Jankovic J, Guo Y, Xie W, Le W: Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1133-8. Epub 2005 Oct 6. PTEN-induced kinase 1 (PINK1) is a recently identified gene, mutations of which cause -responsive parkinsonism. Incubation with PINK1 siRNA decreased SH-SY5Y cell viability and significantly increased MPP (+) or rotenone-induced cytotoxicity. |
1(0,0,0,1) | Details |
| 11368352 | Salsman S, Felts N, Pye QN, Floyd RA, Hensley K: Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN. Arch Biochem Biophys. 2001 Feb 15;386(2):275-80. Treatment with rotenone or antimycin A also resulted in increased wortmannin-sensitive Akt phosphorylation, probably by increasing intracellular H2O2 generation by blocking mitochondrial electron transport. |
0(0,0,0,0) | Details |