| Name | glycogen synthase kinase 3 |
|---|---|
| Synonyms | GSK 3 beta; GSK3 beta; GSK3B; GSK3B protein; Glycogen synthase kinase 3 beta; GSK3 betas; GSK3B proteins; Glycogen synthase kinase 3 betas… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19033437 | Gimenez-Cassina A, Lim F, Cerrato T, Palomo GM, Diaz-Nido J: Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3. J Biol Chem. 2009 Jan 30;284(5):3001-11. Epub 2008 Nov 25. Because glycogen synthase kinase-3 (GSK-3) is considered to be a critical factor in regulating neuronal cell survival and death, we studied the effects of modulating GSK-3 activity in cultured neurons treated with the mitochondrial inhibitor, rotenone. |
32(0,1,1,2) | Details |
| 11689167 | King TD, Bijur GN, Jope RS: Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res. 2001 Nov 16;919(1):106-14. To test if these regulatory interactions applied to other mitochondrial complex I inhibitors, cells were treated with rotenone. |
2(0,0,0,2) | Details |
| 15812315 | King TD, Jope RS: Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress. Neuroreport. 2005 Apr 25;16(6):597-601. Glycogen synthase kinase-3 often promotes apoptosis, so this investigation tested whether glycogen synthase kinase-3 is linked to oxidative stress-induced apoptosis. Both intrinsic oxidative stress induced by the mitochondrial inhibitor rotenone and extrinsic oxidative stress induced by exogenously added H2O2 activated Bax, caspase-2, and caspase-3 in human neuroblastoma SH-SY5Y cells. |
2(0,0,0,2) | Details |
| 18508033 | Chen YY, Chen G, Fan Z, Luo J, Ke ZJ: GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells. Biochem Pharmacol. 2008 Jul 1;76(1):128-38. Epub 2008 Apr 29. Glycogen synthase kinase 3beta (GSK3beta), a multifunctional serine/threonine kinase, has been implicated in the pathogenesis of neurodegeneration. |
1(0,0,0,1) | Details |
| 16678157 | Lai JS, Zhao C, Warsh JJ, Li PP: Cytoprotection by lithium and varies between cell types and cellular stresses. Eur J Pharmacol. 2006 Jun 6;539(1-2):18-26. Epub 2006 Apr 5. Pretreatment of SH-SY5Y cells for 7 days, but not 1 day, with 1 mM of lithium or 0.6 mM of significantly reduced rotenone and H2O2-induced cytotoxicity, cytochrome c release and caspase-3 activation, and increased Bcl-2 levels. |
0(0,0,0,0) | Details |