| 10063813 |
Molano F, Saborido A, Delgado J, Moran M, Megias A: Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Med Sci Sports Exerc. 1999 Feb;31(2):243-50.
METHODS: Sedentary and treadmill-trained (25 m x min (-1), 45 min x d (-1), 5 d x wk (-1)) male rats were treated with fluoxymesterone, methylandrostanolone, or stanozolol (2 mg x kg body weight (-1), 5 d x wk (-1)) for 8 wk.
The mitochondrial respiratory chain activities rotenone-sensitive NADH-cytochrome c reductase (NCCR), succinate cytochrome c reductase (SCCR), and cytochrome oxidase (COX) showed a significant decrease in steroid-administered rats, whereas citrate synthase (CS), a matrix enzyme, exhibited no changes in activity, pointing to a selective effect of AAS on mitochondrial membrane complexes. |
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