| Name | protein as |
|---|---|
| Synonyms | A1 activator; PSAP; Protein C; CSAct; Cerebroside sulfatase activator; Cerebroside sulfate activator; Co beta glucosidase; Component C… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18850458 | Hayworth CR, Rojas JC, Gonzalez-Lima F: Transgenic mice expressing cyan fluorescent protein as a reporter strain to detect the effects of rotenone toxicity on retinal ganglion cells. J Toxicol Environ Health A. 2008;71(24):1582-92. |
6(0,0,1,1) | Details |
| 1735444 | De Vries S, Van Witzenburg R, Grivell LA, Marres CA: Primary structure and import pathway of the rotenone-insensitive NADH-ubiquinone oxidoreductase of mitochondria from Saccharomyces cerevisiae. Eur J Biochem. 1992 Feb 1;203(3):587-92. Both NADH dehydrogenases contain in the central part of the protein a sequence predicted to fold into a beta alpha beta structure involved in the binding of or FAD (H2). |
1(0,0,0,1) | Details |
| 16034640 | Baby SM, Roy A, Lahiri S: Role of mitochondria in the regulation of hypoxia-inducible factor-1alpha in the rat carotid body glomus cells. Histochem Cell Biol. 2005 Jul;124(1):69-76. Epub 2005 Jul 22. Hypoxia-inducible factor-1alpha (HIF-1alpha) protein, a heterodimeric transcription factor that regulates transcriptional activation of several genes, is involved in adaptive responses to hypoxia. To test this hypothesis in the CB glomus cells, we studied the effect of mitochondrial electron transport chain (ETC) inhibitors: rotenone (complex I; 1 microM), (complex II; 0.5 M), antimycin A (complex III; 1 microg/ml), azide (complex IV; 5 mM), and uncoupler of oxidative phosphorylation: carbonyl p-trifluoromethoxyphenylhydrazone (FCCP; 1 mM) on HIF-1alpha expression during normoxia and hypoxia. |
1(0,0,0,1) | Details |
| 3426243 | Hohl C, Oestreich R, Rosen P, Wiesner R, Grieshaber M: Evidence for production by reduction of during hypoxia in isolated adult rat heart cells. Arch Biochem Biophys. 1987 Dec;259(2):527-35. Myocytes incubated for 60 min under hypoxic conditions showed a slight loss of ATP from an initial value of 21 +/- 1 nmol/mg protein, a decline of CP from 42 to 17 nmol/mg protein and a fourfold increase in lactic acid production to 1.8 +/- 0.2 mumol/mg protein/h. Moreover, anaerobic formation was rotenone sensitive. |
1(0,0,0,1) | Details |
| 20117172 | Dadakhujaev S, Noh HS, Jung EJ, Cha JY, Baek SM, Ha JH, Kim DR: Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. Neurosci Lett. 2010 Mar 12;472(1):47-52. Epub 2010 Feb 1. LC3-II protein, a critical marker for autophagy, was produced in an autophagy-dependent manner. |
1(0,0,0,1) | Details |
| 12716939 | Ren Y, Zhao J, Feng J: Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci. 2003 Apr 15;23(8):3316-24. Taken together, our results show that parkin is a novel tubulin-binding protein, as well as a microtubule-associated protein. In addition to inhibiting the mitochondrial respiratory chain, toxins known to cause Parkinson's disease (PD), such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and rotenone, also strongly depolymerize microtubules and increase tubulin degradation. |
1(0,0,0,1) | Details |
| 14731260 | Michalecka AM, Agius SC, Moller IM, Rasmusson AG: Identification of a mitochondrial external dehydrogenase by overexpression in transgenic Nicotiana sylvestris. Plant J. 2004 Feb;37(3):415-25. Activities of external and internal rotenone-insensitive NADH dehydrogenases were unchanged in the transgenic lines. Transgenic lines overexpressing St-ndb1 had specifically increased protein levels for alternative oxidase and uncoupling protein, as compared to the WT and one co-suppressing line. |
1(0,0,0,1) | Details |
| 4303099 | Bois R, Estabrook RW: Nonheme iron protein as a possible site of rotenone inhibition of mitochondrial NADH dehydrogenase. Arch Biochem Biophys. 1969 Jan;129(1):362-9. |
31(0,1,1,1) | Details |