| Name | ubiquinone reductase |
|---|---|
| Synonyms | B13; CI 13KD B; Complex I subunit B13; Complex I 13kD B; NADH Ubiquinone oxidoreductase 1 alpha subcomplex 5; NADH Ubiquinone oxidoreductase subunit B13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; NADH ubiquinone oxidoreductase 13 kDa B subunit… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 39543 | Takeshige K, Minakami S: - and -dependent formation of anions by bovine heart submitochondrial particles and -ubiquinone reductase preparation. Biochem J. 1979 Apr 15;180(1):129-35. The reaction was inhibited by treatment of the preparation with p-hydroxymercuribenzoate and stimulated by treatment with rotenone. |
1(0,0,0,1) | Details |
| 15465329 | Andreani A, Granaiola M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Recanatini M, Lenaz G, Fato R, Bergamini C: Effects of new -imidazo [2,1-b] thiazoles on mitochondrial complex I -ubiquinone reductase) and on mitochondrial permeability transition pore. Bioorg Med Chem. 2004 Nov 1;12(21):5525-32. Moreover the low rotenone sensitivity for almost all of these compounds suggests that they are only partially able to interact with the physiological -reduction site. |
1(0,0,0,1) | Details |
| 195520 | Cadenas E, Boveris A, Ragan CI, Stoppani AO: Production of radicals and peroxide by -ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys. 1977 Apr 30;180(2):248-57. |
1(0,0,0,1) | Details |
| 3134033 | Filser M, Werner S: Pethidine analogues, a novel class of potent inhibitors of mitochondrial ubiquinone reductase. Biochem Pharmacol. 1988 Jul 1;37(13):2551-8. Dose-response curves revealed that the potency of these compounds is very comparable to that of the standard probe rotenone. |
1(0,0,0,1) | Details |
| 9230920 | Zharova TV, Vinogradov AD: A competitive inhibition of the mitochondrial NADH-ubiquinone oxidoreductase (complex I) by ADP- Biochim Biophys Acta. 1997 Jul 4;1320(3):256-64. Ki for inhibition of the rotenone-sensitive oxidase in SMP by ADPR does not depend on delta mu H+. The results obtained are consistent with the proposal on different nucleotide-binding sites operating in the direct and reverse reactions catalyzed by the mitochondrial -ubiquinone reductase. |
1(0,0,0,1) | Details |
| 6294105 | Suzuki H, King TE: Evidence of an radical (s) from the -ubiquinone reductase of the mitochondrial respiratory chain. J Biol Chem. 1983 Jan 10;258(1):352-8. The radical was virtually abolished by adding rotenone, whereas rotenone had no effect on the reduction of FMN by |
1(0,0,0,1) | Details |
| 2871147 | Sugiyama Y, Fujita T, Matsumoto M, Okamoto K, Imada I: Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs. J Pharmacobiodyn. 1985 Dec;8(12):1006-17. These facts and results of inhibitor analysis suggest that the action site of CV-2619 is -linked complex I in the mitochondrial respiratory chain and is different from that of inhibitors of oxidative phosphorylation such as rotenone, oligomycin and 2,4-dinitrophenol. |
0(0,0,0,0) | Details |
| 14665431 | Feldkamp T, Kribben A, Roeser NF, Senter RA, Kemner S, Venkatachalam MA, Nissim I, Weinberg JM: Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol. 2004 Apr;286(4):F749-59. Epub 2003 Dec 9. During titration of complex I activity with rotenone, progressive reduction of NAD+ to was detected at > 20% complex I inhibition, but substantial decreases in ATP levels and mitochondrial membrane potential did not occur until > 70% inhibition. |
0(0,0,0,0) | Details |
| 7925463 | Ueno H, Miyoshi H, Ebisui K, Iwamura H: Comparison of the inhibitory action of natural rotenone and its stereoisomers with various -ubiquinone reductases. Eur J Biochem. 1994 Oct 1;225(1):411-7. Rotenone and 5'beta-epirotenone inhibited the -ubiquinone reductase of bovine heart SMP in a noncompetitive manner against exogenous quinones. |
113(1,2,2,3) | Details |
| 8226801 | Ohtsuka T, Nishijima M, Suzuki K, Akamatsu Y: Mitochondrial dysfunction of a cultured Chinese hamster ovary cell mutant deficient in J Biol Chem. 1993 Oct 25;268(30):22914-9. Of the respiratory chain complexes, rotenone-sensitive -ubiquinone reductase (Complex I) was most severely impaired in the mutant, whereas its activity was restored in a revertant of the mutant that had regained the ability to synthesize CL. |
81(1,1,1,1) | Details |
| 9131045 | Grivennikova VG, Maklashina EO, Gavrikova EV, Vinogradov AD: Interaction of the mitochondrial -ubiquinone reductase with rotenone as related to the enzyme active/inactive transition. Biochim Biophys Acta. 1997 Apr 11;1319(2-3):223-32. |
81(1,1,1,1) | Details |
| 14963044 | Batandier C, Leverve X, Fontaine E: Opening of the mitochondrial permeability transition pore induces reactive species production at the level of the respiratory chain complex I. J Biol Chem. 2004 Apr 23;279(17):17197-204. Epub 2004 Feb 11. Moreover, PTP opening decreased rotenone-sensitive ubiquinone reductase activity, whereas it did not affect the FeCN reductase activity. |
0(0,0,0,0) | Details |
| 10371157 | Galkin AS, Grivennikova VG, Vinogradov AD: --> H+/2e- stoichiometry in -quinone reductase reactions catalyzed by bovine heart submitochondrial particles. FEBS Lett. 1999 May 21;451(2):157-61. Rotenone, piericidin and thermal deactivation of complex I completely prevented -induced translocation in the -endogenous ubiquinone reductase reaction. |
81(1,1,1,1) | Details |
| 1900156 | Anderson WM, Chambers BB, Wood JM, Benninger L: Inhibitory effects of two structurally related carbocyanine laser dyes on the activity of bovine heart mitochondrial and Paracoccus denitrificans -ubiquinone reductase. Biochem Pharmacol. 1991 Mar 1;41(5):677-84. The mechanism of inhibition (except for the HIDC effect on reduction with P. denitrificans) appeared to be through the interaction of dye with the rotenone site on -ubiquinone reductase (EC 1.6.99.3), since rotenone-insensitive preparations of complex I and P. denitrificans membrane vesicles were also insensitive to HIDC and HITC inhibition. |
81(1,1,1,1) | Details |
| 1932041 | Bironaite DA, Cenas NK, Kulys JJ: The rotenone-insensitive reduction of quinones and nitrocompounds by mitochondrial NADH:ubiquinone reductase. Biochim Biophys Acta. 1991 Oct 18;1060(2):203-9. The rotenone-insensitive reduction of quinones and aromatic nitrocompounds by mitochondrial ubiquinone reductase (complex I, EC 1.6.99.3) has been studied. |
81(1,1,1,1) | Details |
| 8442768 | Anderson WM, Delinck DL, Benninger L, Wood JM, Smiley ST, Chen LB: Cytotoxic effect of thiacarbocyanine dyes on human colon carcinoma cells and inhibition of bovine heart mitochondrial -ubiquinone reductase activity via a rotenone-type mechanism by two of the dyes. Biochem Pharmacol. 1993 Feb 9;45(3):691-6. |
62(0,2,2,2) | Details |
| 2119805 | Kotlyar AB, Vinogradov AD: Slow active/inactive transition of the mitochondrial -ubiquinone reductase. Biochim Biophys Acta. 1990 Aug 30;1019(2):151-8. The deactivated state of the enzyme in coupled particles was revealed as: (i) the absence of the rotenone-sensitive, delta mu H (+)-dependent -ferricyanide reductase activity; (ii) a prominent lag in the aerobic -supported, delta mu H (+)-dependent NAD+ reduction; and (iii) a lag in the rotenone-sensitive -ubiquinone reductase or oxidase activities. |
39(0,1,2,4) | Details |
| 8882715 | Takahashi T, Okamoto T, Kishi T: Characterization of -dependent ubiquinone reductase activity in rat liver cytosol: effect of various factors on -reducing activity and discrimination from other quinone reductases. J Biochem. 1996 Feb;119(2):256-63. Rotenone, antimycin A, and KCN, which inhibit mitochondrial and microsomal electron transfer enzymes, superoxide dismutase, and acetylated cytochrome c had no effect on the -UQ reductase activity. |
2(0,0,0,2) | Details |
| 12515859 | Miyadera H, Shiomi K, Ui H, Yamaguchi Y, Masuma R, Tomoda H, Miyoshi H, Osanai A, Kita K, Omura S: Atpenins, potent and specific inhibitors of mitochondrial complex II - oxidoreductase). Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):473-7. Epub 2003 Jan 6. The use of specific and potent inhibitors of complex I -ubiquinone reductase) and complex III (ubiquinol-cytochrome c reductase), such as rotenone and antimycin, respectively, has allowed determination of the role of these enzymes in physiological processes. |
33(0,1,1,3) | Details |
| 7763312 | Anderson WM, Trgovcich-Zacok D: Carbocyanine dyes with long alkyl side-chains: broad spectrum inhibitors of mitochondrial electron transport chain activity. Biochem Pharmacol. 1995 May 11;49(9):1303-11. Certain indocarbocyanine, thiacarbocyanine, and oxacarbocyanine dyes possessing short alkyl side-chains (one to five carbons) are potent inhibitors of mammalian mitochondrial -ubiquinone reductase (EC 1.6.99.3) activity (Anderson et al., Biochem Pharmacol 41: 677-684, 1991; Anderson et al., Biochem Pharmacol 45: 691-696, 1993; Anderson et al., Biochem Pharmacol 45: 2115-2122, 1993), and act similarly to rotenone. |
32(0,1,1,2) | Details |
| 2515858 | Anderson WM, Patheja HS, Delinck DL, Baldwin WW, Smiley ST, Chen LB: Inhibition of bovine heart mitochondrial and Paracoccus denitrificans ----ubiquinone reductase by dequalinium and three structurally related quinolinium compounds. Biochem Int. 1989 Oct;19(4):673-85. Studies comparing DECA inhibition of rotenone-sensitive with rotenone-insensitive preparations indicate that DECA acts by a different inhibitory mechanism than rotenone on mammalian mitochondrial and P. denitrificans ----ubiquinone reductase. |
32(0,1,1,2) | Details |
| 823748 | Schewe T, Hiebsch C, Halangk W: [Action of the systemic fungicide dexon on several NADH dehydrogenases] . Acta Biol Med Ger. 1975;34(11-12):1767-75. Soluble -cytochrome c-oxidoreductase (MAHLER) and rotenone-insensitive ubiquinone reductase are also inhibited by dexon. |
31(0,1,1,1) | Details |
| 8804391 | da Silva MV, Alves PC, Duarte M, Mota N, Lobo-da-Cunha A, Harkness TA, Nargang FE, Videira A: Disruption of the nuclear gene encoding the 20.8-kDa subunit of ubiquinone reductase of Neurospora mitochondria. Mol Gen Genet. 1996 Aug 27;252(1-2):177-83. The ubiquinone reductase activity of sonicated mitochondria from the mutant is rotenone insensitive. |
8(0,0,1,3) | Details |
| 4147655 | Ragan CI, Racker E: Resolution and reconstitution of the mitochondrial electron transport system. J Biol Chem. 1973 Oct 10;248(19):6876-84. The reconstitution of rotenone-sensitive -ubiquinone reductase from dehydrogenase and phospholipids. |
6(0,0,1,1) | Details |
| 4144294 | Lawford HG, Garland PB: translocation coupled to reduction by reduced -- dinucleotide in rat liver and ox heart mitochondria. Biochem J. 1972 Dec;130(4):1029-44. It is concluded that the rotenone-sensitive - ubiquinone reductase activity of the respiratory chain may be organized in the mitochondrial membrane as a -translocating oxidoreduction loop. |
6(0,0,1,1) | Details |
| 1730007 | Kotlyar AB, Sled VD, Vinogradov AD: Effect of Ca2+ ions on the slow active/inactive transition of the mitochondrial -ubiquinone reductase. Biochim Biophys Acta. 1992 Jan 16;1098(2):144-50. When oxidase, the rotenone-sensitive -ubiquinone reductase or the -supported delta mu H+-dependent NAD+ reduction were initiated by the deactivated enzyme preparations all the three activities were strongly inhibited by Ca2+; no sensitivity of these reactions to Ca2+ was observed when the assays were started by the activated enzyme preparations. |
3(0,0,0,3) | Details |
| 4288750 | Pharo RL, Sordahl LA, Vyas SR, Sanadi DR: Studies on ubiquinone reductase. J Biol Chem. 1966 Oct 25;241(20):4771-80. |
2(0,0,0,2) | Details |
| 9593904 | Degli Esposti M: Inhibitors of -ubiquinone reductase: an overview. Biochim Biophys Acta. 1998 May 6;1364(2):222-35. The inhibitors are presented within the broad categories of natural and commercial compounds and their potency is related to that of rotenone, the classical inhibitor of complex I. |
2(0,0,0,2) | Details |
| 6786284 | Takeshige K, Takayanagi R, Minakami S: Lipid peroxidation and the reduction of ADP-Fe3+ chelate by -ubiquinone reductase preparation from bovine heart mitochondria. Biochem J. 1980 Dec 15;192(3):861-6. The apparent Km values for the coenzymes and the optimal pH of the reactions agreed well with those of the lipid peroxidation of the submitochondrial particles treated with rotenone. |
2(0,0,0,2) | Details |
| 3930501 | Gondal JA, Anderson WM: The molecular morphology of bovine heart mitochondrial ----ubiquinone reductase. J Biol Chem. 1985 Oct 15;260(23):12690-4. Native disulfide-linked subunits and rotenone-induced conformational changes.. |
2(0,0,0,2) | Details |
| 8037664 | Degli Esposti M, Ghelli A, Ratta M, Cortes D, Estornell E: Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I). Biochem J. 1994 Jul 1;301 ( Pt 1):161-7. Natural products from the plants of the family Annonaceae, collectively called Annonaceous acetogenins, are very potent inhibitors of the -ubiquinone reductase (Complex I) activity of mammalian mitochondria. The properties of five of such acetogenins are compared with those of rotenone and piericidin, classical potent inhibitors of Complex I. |
1(0,0,0,1) | Details |
| 7707312 | Andreani A, Rambaldi M, Leoni A, Locatelli A, Ghelli A, Ratta M, Benelli B, Degli Esposti M: Thienylimidazo [2,1-b] thiazoles as inhibitors of mitochondrial NADH dehydrogenase. J Med Chem. 1995 Mar 31;38(7):1090-7. These compounds were tested as specific inhibitors of the ubiquinone (UBQ) reductase activity of NADH dehydrogenase in mitochondrial membranes. This compound is noncompetitive with the substrate and interacts with a site which is mutually exclusive with that of rotenone but nonexclusive with that of piericidin and several other inhibitors of NADH dehydrogenase. |
1(0,0,0,1) | Details |
| 8443209 | Shigemura T, Kang D, Nagata-Kuno K, Takeshige K, Hamasaki N: Characterization of NAD (P) H-dependent ubiquinone reductase activities in rat liver microsomes. Biochim Biophys Acta. 1993 Mar 1;1141(2-3):213-20. The -dependent oxidoreduction system was different from the -dependent system because of the following observations; (1) rotenone inhibited only the -dependent reductase, (2) dicoumarol inhibited the -dependent reduction more potently than the -dependent reduction and (3) the activity oxidizing the -10 in the presence of was less than that in the presence of |
1(0,0,0,1) | Details |
| 8573592 | Satoh T, Miyoshi H, Sakamoto K, Iwamura H: Comparison of the inhibitory action of synthetic analogues with various NADH-ubiquinone oxidoreductases. Biochim Biophys Acta. 1996 Jan 11;1273(1):21-30. A series of analogues was synthesized to examine the structural factors required for the inhibitory action and to probe the structural property of the catalytic site of various -ubiquinone reductases, including non--pumping enzyme (NDH-2), from bovine heart mitochondria, potato tuber (Solanum tuberosum, L) mitochondria and Escherichia coli (GR 19N) plasma membranes. Some synthetic capsaicins were fairly potent inhibitors of each of the three NDH-1 compared with the potent rotenone and piericidin A. |
1(0,0,0,1) | Details |
| 18486594 | Fendel U, Tocilescu MA, Kerscher S, Brandt U: Exploring the inhibitor binding pocket of respiratory complex I. . Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):660-5. Epub 2008 Apr 30. Numerous hydrophobic and amphipathic compounds including several detergents are known to inhibit the ubiquinone reductase reaction of respiratory chain complex I pumping NADH:ubiquinone oxidoreductase). Many mutations around the domain of the 49-kDa subunit that is homologous to the [NiFe] centre binding region of hydrogenase conferred resistance to DQA (class I/type A) and rotenone (class II/type B) indicating a wider overlap of the binding sites for these two types of inhibitors. |
1(0,0,0,1) | Details |
| 4172972 | Pharo RL, Sordahl LA, Edelhoch H, Sanadi DR: Studies on ubiquinone reductase. Arch Biochem Biophys. 1968 May;125(2):416-28. |
1(0,0,0,1) | Details |
| 11325348 | Cormier A, Morin C, Zini R, Tillement JP, Lagrue G: In vitro effects of on mitochondrial respiration and generation. Brain Res. 2001 May 4;900(1):72-9. bound to complex I of the respiratory chain and inhibited the -Ubiquinone reductase activity. |
1(0,0,0,1) | Details |
| 8656275 | Higgins DS Jr, Greenamyre JT: [3H] dihydrorotenone binding to ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J Neurosci. 1996 Jun 15;16(12):3807-16. To enhance the anatomic precision with which complex I can be examined, we developed an autoradiographic assay for the rotenone site of this enzyme. [3H] dihydrorotenone ([3H] DHR) binding is saturable (KD = 15-55 nM) and specific, and Hill slopes of 1 suggest a single population of binding sites. |
1(0,0,0,1) | Details |
| 3094534 | Suzuki H, Wakai M, Ozawa T: Selective inhibition of mitochondrial -ubiquinone reductase (Complex I) by an alkyl polyoxyethylene ether. Biochem Int. 1986 Aug;13(2):351-7. The detergent inhibited rotenone-sensitive -ubiquinone reductase activity, but not -ferricyanide reductase activity, of isolated Complex I. |
1(0,0,0,1) | Details |
| 18140 | Ragan CI, Bloxham DP: Specific labelling of a constituent polypeptide of bovine heart mitochondrial -ubiquinone reductase by the inhibitor diphenyleneiodonium. Biochem J. 1977 Jun 1;163(3):605-15. Rotenone increased the apparent affinity of diphenyleneiodonium for the 23500-mol.wt. polypeptide without affecting the maximum incorporation. 8. |
1(0,0,0,1) | Details |