| Name | Cytochrome c oxidase (protein family or complex) |
|---|---|
| Synonyms | COX; cytochrome c oxidase; cytochrome c oxidases |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2170057 | Yamamoto M, Akiyama C, Aikawa H: D-penicillamine-induced copper deficiency in suckling mice: neurological abnormalities and brain mitochondrial enzyme activities. Brain Res Dev Brain Res. 1990 Aug 1;55(1):51-5. Cytochrome c oxidase activity (complex IV) in the brain showed 51% decrease of the controls, on the contrary, rotenone-sensitive cytochrome c reductase (complex I + III) and cytochrome c reductase (complex II + III) were normal. |
33(0,1,1,3) | Details |
| 15448140 | Schonfeld C, Wobbe L, Borgstadt R, Kienast A, Nixon PJ, Kruse O: The nucleus-encoded protein MOC1 is essential for mitochondrial light acclimation in Chlamydomonas reinhardtii. J Biol Chem. 2004 Nov 26;279(48):50366-74. Epub 2004 Sep 23. The absence of MOC1 leads to a reduction in the levels of cytochrome c oxidase and of rotenone-insensitive external dehydrogenase activities of the mitochondrial respiratory electron transfer chain. |
32(0,1,1,2) | Details |
| 19861415 | Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB: Pyrroloquinoline stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52. Epub 2009 Oct 27. Moreover, PQQ protected cells from mitochondrial inhibition by rotenone, 3-nitropropionic acid, antimycin A, and azide. Exposure of mouse Hepa1-6 cells to 10-30 microm PQQ for 24-48 h resulted in increased citrate synthase and cytochrome c oxidase activity, Mitotracker staining, mitochondrial DNA content, and cellular respiration. |
1(0,0,0,1) | Details |
| 18224432 | Shiryaeva A, Baidyuk E, Arkadieva A, Okovityy S, Morozov V, Sakuta G: Hepatocyte mitochondrion electron-transport chain alterations in CCl (4) and induced hepatitis in rats and their correction with J Bioenerg Biomembr. 2008 Feb;40(1):27-34. Epub 2008 Jan 26. Rotenone resulted in 27% suppression of respiration by pathological hepatocytes whereas 2,4-dinitrophenol produced a 1.4-fold increase of respiration. Cytochrome c oxidase activity in hepatitis was 1.8-fold higher compared with control. |
1(0,0,0,1) | Details |
| 14638429 | Palese LL, Gaballo A, Technikova-Dobrova Z, Labonia N, Abbrescia A, Scacco S, Micelli L, Papa S: Characterization of plasma membrane respiratory chain and ATPase in the actinomycete Nonomuraea sp. FEMS Microbiol Lett. 2003 Nov 21;228(2):233-9. The respiratory chain is made up of a rotenone-sensitive -quinone oxidoreductase, a four subunits aa3-type cytochrome c oxidase and a bc1 complex. |
31(0,1,1,1) | Details |
| 10876012 | Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J: Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta. 2000 Aug;298(1-2):157-73. In this paper, we present a complex protocol for evaluation of the function of mitochondrial OXPHOS enzymes in cultured amniocytes using three independent and complementary methods: (a) spectrophotometry as a tool for determination of the capacities of mitochondrial respiratory-chain enzymes (NADH ubiquinone oxidoreductase, - and glycerophosphate cytochrome c reductase, cytochrome c oxidase and citrate synthase); (b) polarography as a tool for the evaluation of mitochondrial OXPHOS enzyme functions in situ using digitonin-permeabilised amniocytes (rotenone-sensitive oxidation of pyruvate+malate, antimycin A-sensitive oxidation of KCN-sensitive oxidation of cytochrome c, -activated substrate oxidation) and (c) cytofluorometric determination of tetramethyl rhodamine methyl ester (TMRM) fluorescence in digitonin-permeabilised amniocytes as a sensitive way to determine the mitochondrial membrane potential under steady-state conditions (state 4 with |
31(0,1,1,1) | Details |
| 7607228 | Wisniewski E, Gellerich FN, Kunz WS: Distribution of flux control among the enzymes of mitochondrial oxidative phosphorylation in -activated saponin-skinned rat musculus soleus fibers. Eur J Biochem. 1995 Jun 1;230(2):549-54. The flux control coefficients of H (+)-ATPase, -nucleotide translocase, transporter, NADH:ubiquinone oxidoreductase and cytochrome-c oxidase were determined to be equal to 0.16 +/- 0.08 (n = 6), 0.34 +/- 0.12 (n = 5), 0.08 +/- 0.03 (n = 5), 0.01 +/- 0.006 (n = 4) and 0.09 +/- 0.03 (n = 3) using inhibitor titrations with the specific inhibitors oligomycin, carboxyatractyloside, mersalyl, rotenone and respectively, and applying non-linear regression of the entire titration curve. |
31(0,1,1,1) | Details |
| 8031121 | Takamiya S, Wang H, Hiraishi A, Yu Y, Hamajima F, Aoki T: Respiratory chain of the lung fluke Paragonimus westermani: facultative anaerobic mitochondria. Arch Biochem Biophys. 1994 Jul;312(1):142-50. The specific activities of oxidoreductases composing the oxidase system, i.e., -ubiquinone and --cytochrome c oxidoreductase (complex II and complex II-III, respectively) and cytochrome c oxidase (complex IV), were compared in mitochondria from adult Paragonimus, bovine heart (an aerobic tissue), and muscle of adult Ascaris suum which possesses an anaerobic respiratory chain. |
1(0,0,0,1) | Details |
| 16234867 | Chen Y, Suzuki I: Effects of electron transport inhibitors and uncouplers on the oxidation of ferrous iron and compounds interacting with ferric iron in Acidithiobacillus ferrooxidans. Can J Microbiol. 2005 Aug;51(8):695-703. All the oxidations were sensitive to inhibitors of cytochrome c oxidase, KCN, and NaN3. The oxidation rates of Fe2+ and inhibited by complex I and complex III inhibitors (amytal, rotenone, antimycin A, myxothiazol, and HQNO) were stimulated more extensively by uncouplers than the control rates. |
1(0,0,0,1) | Details |
| 12632423 | Maneiro E, Martin MA, de Andres MC, Lopez-Armada MJ, Fernandez-Sueiro JL, del Hoyo P, Galdo F, Arenas J, Blanco FJ: Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes. Arthritis Rheum. 2003 Mar;48(3):700-8. The activities of mitochondrial respiratory chain complexes (complex I: rotenone-sensitive - (1) reductase; complex II: succinate dehydrogenase; complex III: antimycin-sensitive ubiquinol cytochrome c reductase; and complex IV: cytochrome c oxidase) and CS were measured in human articular chondrocytes isolated from OA and normal cartilage. |
31(0,1,1,1) | Details |
| 1661844 | Dagani F, Ferrari R, Anderson JJ, Chase TN: does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria. Mov Disord. 1991;6(4):315-9. The maximum activities related to complexes of the respiratory chain: rotenone-sensitive -cytochrome c reductase, -cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17-19 days of treatment. |
31(0,1,1,1) | Details |
| 1546970 | Nelson D, Rumsey WL, Erecinska M: catabolism by heart muscle. Biochem J. 1992 Mar 1;282 ( Pt 2):559-64. Rat heart homogenates catabolized in the presence of rotenone, an inhibitor of the respiratory chain. 2. Distribution of the activity was the same as that of a mitochondrial marker, cytochrome c oxidase. 6. |
1(0,0,0,1) | Details |
| 11245784 | Joseph-Horne T, Hollomon DW, Wood PM: Fungal respiration: a fusion of standard and alternative components. Biochim Biophys Acta. 2001 Apr 2;1504(2-3):179-95. These consist of alternative NADH dehydrogenases, which catalyse rotenone insensitive oxidation of matrix or enable cytoplasmic to be used directly. The alternative oxidase enables respiration to continue in the presence of inhibitors for ubiquinol:cytochrome c oxidoreductase and cytochrome c oxidase. |
1(0,0,0,1) | Details |
| 10841308 | de Halac IN, Bacman SR, de Kremer RD: Histoenzymology of oxidases and dehydrogenases in peripheral blood lymphocytes and monocytes for the study of mitochondrial oxidative phosphorylation. Histochem J. 2000 Mar;32(3):133-7. The specificity of each histoenzymological reaction was tested using a specific respiratory chain inhibitor: rotenone for diaphorase, thenoyltrifluoroacetone for succinate dehydrogenase, for cytochrome c oxidase and oligomycin for ATPase. |
31(0,1,1,1) | Details |
| 10683230 | Wiedemann FR, Vielhaber S, Schroder R, Elger CE, Kunz WS: Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples. Anal Biochem. 2000 Mar 1;279(1):55-60. The measurement of cytochrome c oxidase activity in the presence of 200 microM ferrocytochrome c and the detection of NADH:CoQ oxidoreductase as rotenone-sensitive NADH:CoQ (1) reductase resulted in comparable citrate synthase-normalized respiratory chain enzyme activities of both isolated mitochondria and homogenates from control human skeletal muscle samples. |
7(0,0,1,2) | Details |
| 18353899 | Brown ST, Nurse CA: Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line. Am J Physiol Cell Physiol. 2008 Jun;294(6):C1305-12. Epub 2008 Mar 19. Hypoxia (2-8% O2) caused a concentration- and time-dependent increase in HIF-2alpha induction, which was blocked in MAH cells with either RNA interference knockdown of the Rieske Fe-S protein, a component of complex III, or knockdown of cytochrome-c oxidase subunit of complex IV, or defective mitochondrial DNA (rho0 cells). Additionally, pharmacological inhibitors of mitochondrial complexes I, III, IV, i.e., rotenone (1 microM), myxothiazol (1 microM), antimycin A (1 microg/ml), and (1 mM), blocked HIF-2alpha induction in control MAH cells. |
1(0,0,0,1) | Details |
| 11053976 | Wang S, Solin M, Ahola H, Luimula P, Holthofer H: Interactions between mitochondrial proteins and lipid peroxidation products in the maintenance of the glomerular filtration barrier in the in vitro perfused kidney. Exp Nephrol. 2001;9(1):14-20. BACKGROUND: The fourth complex of the mitochondrial respiratory chain, cytochrome-c oxidase (CytC) consists of thirteen both mitochondrially and nuclearly encoded subunits, which are differently regulated in proteinuric kidneys. METHODS: We set up an in vitro kidney perfusion model to study the direct effect of inhibitors of the mitochondrial respiratory chain, rotenone and antimycin A, on the glomerular filtration barrier by using immunohistochemistry and Northern blotting and quantitating the resulting proteinuria. |
1(0,0,0,1) | Details |
| 3412635 | Lucas-Heron B, Loirat MJ, Ollivier B: Severe mitochondrial anomaly in dystrophic mouse skeletal muscle. . Neurosci Lett. 1988 Jul 19;90(1-2):147-51. Mitochondrial fractions were isolated from skeletal muscle of control (C57 BL 6J dy/+) and dystrophic (C57 BL 6J dy/dy) mice, and enzymatic activities (cytochrome c oxidase, rotenone-insensitive cytochrome c reductase) were determined. |
6(0,0,1,1) | Details |
| 6093033 | Papadimitriou A, Neustein HB, Dimauro S, Stanton R, Bresolin N: Histiocytoid cardiomyopathy of infancy: deficiency of reducible cytochrome b in heart mitochondria. Pediatr Res. 1984 Oct;18(10):1023-8. Biochemical studies showed markedly decreased -cytochrome c reductase and rotenone-sensitive -cytochrome c reductase activities, while other mitochondrial enzymes were normal. In isolated mitochondria, cytochrome spectra showed a severe defect of reducible cytochrome b and a less marked defect of cytochrome cc1, while the content of cytochrome aa3 (cytochrome c oxidase) was normal. |
1(0,0,0,1) | Details |
| 3100753 | Kobayashi M, Morishita H, Sugiyama N, Yokochi K, Nakano M, Wada Y, Hotta Y, Terauchi A, Nonaka I: Two cases of NADH-coenzyme Q reductase deficiency: relationship to MELAS syndrome. J Pediatr. 1987 Feb;110(2):223-7. Rotenone-sensitive cytochrome c reductase activities were decreased to 8% (patient 1) and 6% (patient 2) of control values; cytochrome c reductase and cytochrome c oxidase values were within normal limits. |
6(0,0,1,1) | Details |
| 753379 | Comte J, Gautheron DC: The markers of pig heart mitochondrial sub-fractions. Biochimie. 1978;60(11-12):1298-1305. High ionic strength treatments by either NaCl- or 3M KCl have a strong effect, but they also remove cytochrome c oxidase and rotenone-sensitive -cytochrome c reductase, reputed inner membrane intrinsic enzymes, thus strongly damaging the inner membrane. |
6(0,0,1,1) | Details |
| 14713113 | Gnaiger E: conformance of cellular respiration. Adv Exp Med Biol. 2003;543:39-55. In cultured cells, the pronounced uptake above mitochondrial saturation at air-level pressure cannot be inhibited by rotenone and antimycin A, amounting to > 20 % of routine respiration in fibroblasts. pressure declines from normoxic air-level to the microenvironment of mitochondria where cytochrome c oxidase (COX) reduces to water at levels as low as 0.3 kPa (2 Torr; 3 microM; 1.5 % air saturation). |
1(0,0,0,1) | Details |
| 9932647 | Sreeramulu K, Schmidt CL, Schafer G, Anemuller S: Studies of the electron transport chain of the euryarcheon Halobacterium salinarum: indications for a type II NADH dehydrogenase and a complex III analog. J Bioenerg Biomembr. 1998 Oct;30(5):443-53. Complex I inhibitors like rotenone and annonine were inactive, clearly excluding the presence of a coupled NADH dehydrogenase. One of the terminal oxidases could be shown to act as a cytochrome-c oxidase with a Km value of 37 microM and an activation energy of 23.7 kJ/mol. |
1(0,0,0,1) | Details |
| 1337280 | Chapman JC, Waterhouse TB, Michael SD: Changes in mitochondrial and microsomal 3 beta-hydroxysteroid dehydrogenase activity in mouse ovary over the course of the estrous cycle. Biol Reprod. 1992 Dec;47(6):992-7. To ascertain whether the increase in mitochondrial HSD activity at diestrus could be due to a preferential induction of enzyme, its SA and the SA of a mitochondrial inner membrane enzyme, cytochrome C oxidase, were compared to the SA of a mitochondrial outer membrane enzyme, rotenone-insensitive cytochrome C reductase. |
6(0,0,1,1) | Details |
| 1668297 | Araya J, Aguilera AM, Bosco C: [The effect of dietary Omega 6 polyunsaturated fatty acids on the activity of enzymes associated with liver mitochondrial and placental function in rats]. Arch Latinoam Nutr. 1991 Mar;41(1):62-71. Cytochrome c oxidase (a3) and rotenone-insensitive- cytochrome c reductase cyt c red) in mitochondria subfractions were also assayed. |
6(0,0,1,1) | Details |
| 12803488 | Ryu JY, Suh KH, Chung YH, Park YM, Chow WS, Park YI: dehydrogenase-mediated respiratory electron transport in thylakoid membranes of the cyanobacterium Synechocystis sp. Mol Cells. 2003 Apr 30;15(2):240-4. The inhibitors rotenone and mercury with or without 1 mM fully suppressed the post-illumination increase in Chl fluorescence in both dehydrogenase-defective (M55) and deltaCtaI cells. The latter cells lack subunit I of cytochrome aa3-type cytochrome c oxidase. |
1(0,0,0,1) | Details |
| 9642675 | Horakova L, Stolc S, Chromikova Z, Pekarova A, Derkova L: Mechanisms of hippocampal reoxygenation injury. Mol Chem Neuropathol. 1998 Apr;33(3):223-36. The results obtained on using inhibitors of radicals generation, i.e., allopurinol, indomethacin, rotenone, and antimycin A, strongly suggest that the sources of radicals were the /xanthine oxidase system, prostaglandin synthesis, and mitochondrial respiratory chain. Cytochrome-c oxidase was decreased in reoxygenated hippocampal slices treated with stobadine. |
1(0,0,0,1) | Details |
| 2457393 | Kottke M, Adam V, Riesinger I, Bremm G, Bosch W, Brdiczka D, Sandri G, Panfili E: Mitochondrial boundary membrane contact sites in brain: points of hexokinase and kinase location, and control of Ca2+ transport. Biochim Biophys Acta. 1988 Aug 17;935(1):87-102. The fraction was composed of inner and outer limiting membrane components as shown by the specific marker enzymes, succinate dehydrogenase and -cytochrome-c-oxidase (rotenone insensitive). |
6(0,0,1,1) | Details |
| 8184686 | Wu CM, Lee DH, Hong YC, Wen DW, Chou CF, Chung MT: Changes of respiratory chain enzyme activities in growing rat muscle mitochondria. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1994 Mar-Apr;35(2):113-8. The activities of three mitochondrial respiratory chain enzymes, namely rotenone sensitive -cytochrome c reductase (NCCR), -cytochrome c reductase (SCCR), and cytochrome c oxidase (CCO) in the extensor digitorum longus muscle were determined in Wistar rats, twenty each, at 3, 4, 5, 6, 10 and 26 weeks of age. |
6(0,0,1,1) | Details |
| 9475164 | Wiedemann FR, Kunz WS: dependence of flux control of cytochrome c oxidase -- implications for mitochondrial diseases. FEBS Lett. 1998 Jan 23;422(1):33-5. |
4(0,0,0,4) | Details |
| 1316525 | Wanders RJ, Wijburg FA, Ruiter J, Trijbels JM, Ruitenbeek W, Sengers RC, Bakkeren JA, Feller N: Prenatal diagnosis of systemic disorders of the respiratory chain in cultured amniocytes and chorionic villus fibroblasts by studying the formation of lactate and from J Inherit Metab Dis. 1992;15(1):84-91. Formation of lactate and from was studied in cultured amniocytes and chorionic villus fibroblasts from controls, either untreated or treated with azide, an inhibitor of cytochrome c oxidase, or other inhibitors of the mitochondrial respiratory chain. Elevated lactate-to- ratios were also found in chorionic villus fibroblasts in which complexes I, III or IV were inhibited by rotenone, antimycin or azide, respectively. |
2(0,0,0,2) | Details |
| 8383431 | Cogswell AM, Stevens RJ, Hood DA: Properties of skeletal muscle mitochondria isolated from subsarcolemmal and intermyofibrillar regions. Am J Physiol. 1993 Feb;264(2 Pt 1):C383-9. Site 1 inhibition of respiration with rotenone reduced this difference to 1.4-fold. The activities of cytochrome-c oxidase (CYTOX) and succinate dehydrogenase (SDH) could account for some of these differences, since CYTOX was 20% greater (P < 0.05) in IMF mitochondria, and SDH was 40% greater (P < 0.05) in SS mitochondria. |
1(0,0,0,1) | Details |
| 10947970 | Roussel D, Lhenry F, Ecochard L, Sempore B, Rouanet JL, Favier R: Differential effects of endurance training and depletion on regional mitochondrial adaptations in rat skeletal muscle. Biochem J. 2000 Sep 1;350 Pt 2:547-53. Mitochondrial oxidative phosphorylation was assessed polarographically by using plus (plus rotenone), and plus N,N,N',N'-tetramethyl-p-phenylenediamine (TMPD) (plus antimycin) as respiratory substrates. Assays of cytochrome c oxidase and F (1)-ATPase activities were also performed. |
1(0,0,0,1) | Details |
| 39598 | Krab K, Wikstrom M: On the stoichiometry and thermodynamics of -pumping cytochrome c oxidase in mitochondria. Biochim Biophys Acta. 1979 Oct 10;548(1):1-15. Similar results are obtained with either ferrocyanide, N.N.N',N'-tetramethyl-p-phenylenediamine or externally added cytochrome c mediating between and cytochrome c in rotenone- and antimycin-inhibited mitochondria. |
3(0,0,0,3) | Details |
| 1847635 | Demant EJ: Inactivation of cytochrome c oxidase activity in mitochondrial membranes during redox cycling of doxorubicin. Biochem Pharmacol. 1991 Feb 15;41(4):543-52. It is related in a complex manner to the electron flux in the respiratory chain with antioxidant properties, and is maximal at the high reduction level of respiratory chain Complex I obtained in the presence of rotenone. |
3(0,0,0,3) | Details |
| 7476924 | van de Water B, Zoeteweij JP, de Bont HJ, Nagelkerke JF: Inhibition of succinate:ubiquinone reductase and decrease of in nephrotoxic S-conjugate-induced oxidative cell injury. Mol Pharmacol. 1995 Nov;48(5):928-37. KCN cytoprotection could be prevented by inhibition of SQR activity with or TTFA, whereas inhibition of either complex I or III with rotenone and antimycin, respectively, did not prevent it. To investigate this in greater detail, PTC were treated with an inhibitor of cytochrome-c-oxidase, KCN, in a buffer containing which prevents cell death by KCN. |
1(0,0,0,1) | Details |
| 7277330 | Ford WC, Harrison A: The role of oxidative phosphorylation in the generation of ATP in human spermatozoa. J Reprod Fertil. 1981 Sep;63(1):271-8. The presence of 2 microM-antimycin A, 2 microM-rotenone, 0.4 microM-carbonyl m-chlorophenyl hydrazone or 8 microM-oligomycin caused the ATP concentration to fall to less than 2 nmol/10 (8) spermatozoa but their effect was partly alleviated by 2 mM- Cytochrome c oxidase (EC 1.9.3.1) was much less active than in rat spermatozoa (22.3 +/- 6.0 (s.e.m., n = 4) and 615 +/- 87 (n = 4) nmol transformed/10 (8) spermatozoa/min). |
1(0,0,0,1) | Details |
| 8392019 | Sohal RS: Aging, cytochrome oxidase activity, and peroxide release by mitochondria. Free Radic Biol Med. 1993 Jun;14(6):583-8. Cytochrome c oxidase activity was found to sharply decline in the latter part of the life span of the flies. H2O2 release by mitochondria, inhibited with rotenone and antimycin A, was greatly increased upon supplementation with however, the further addition of KCN or myxothiazol, to such preparations, caused a depression of H2O2 generation. |
3(0,0,0,3) | Details |
| 17432597 | Shiriaeva AP, Baidiuk EV, Arkad'eva AV, Okovityi SV, Morozov VI, Sakuta GA: [Hepatocyte mitochondrion respiratory chain in rats with experimental toxic hepatitis]. Tsitologiia. 2007;49(2):125-32. Cytochrome c oxidase activity increased (+ 80%) as compared to control. Rotenone (the inhibitor of the I complex) decreased 27% consumption by pathological hepatocytes while dinitrophenol produced 37% cell respiration increase. |
2(0,0,0,2) | Details |
| 7763312 | Anderson WM, Trgovcich-Zacok D: Carbocyanine dyes with long alkyl side-chains: broad spectrum inhibitors of mitochondrial electron transport chain activity. Biochem Pharmacol. 1995 May 11;49(9):1303-11. Certain indocarbocyanine, thiacarbocyanine, and oxacarbocyanine dyes possessing short alkyl side-chains (one to five carbons) are potent inhibitors of mammalian mitochondrial -ubiquinone reductase (EC 1.6.99.3) activity (Anderson et al., Biochem Pharmacol 41: 677-684, 1991; Anderson et al., Biochem Pharmacol 45: 691-696, 1993; Anderson et al., Biochem Pharmacol 45: 2115-2122, 1993), and act similarly to rotenone. This study examines the inhibitory capacities of twelve other carbocyanine dyes (six indocarbocyanines, four oxacarbocyanines, and two thiacarbocyanines) possessing long alkyl side-chains (seven to eighteen carbons with both saturated and unsaturated side-chains) on mitochondrial and cytochrome c oxidase activities. |
1(0,0,0,1) | Details |
| 11416204 | Shiva S, Brookes PS, Patel RP, Anderson PG, Darley-Usmar VM: partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7212-7. |
1(0,0,0,1) | Details |
| 7632092 | Campos Y, Arenas J, Cabello A, Gomez-Reino JJ: Respiratory chain enzyme defects in patients with idiopathic inflammatory myopathy. Ann Rheum Dis. 1995 Jun;54(6):491-3. Activity of rotenone sensitive cytochrome c reductase (complex I and III) succinate dehydrogenase (complex II), cytochrome c reductase (complex II and III), cytochrome c oxidase (complex IV), and citrate synthase (a mitochondrial matrix enzyme), was measured spectrophotometrically in muscle homogenates. |
81(1,1,1,1) | Details |
| 6317378 | Demant EJ: oxidation in submitochondrial particles protects respiratory chain activity against damage by adriamycin-Fe3+. Eur J Biochem. 1983 Dec 1;137(1-2):113-8. Protection by is strengthened by removal of cytochrome c from the submitochondrial particles and by antimycin A but abolished by rotenone. Inhibition of cytochrome c oxidase activity by the adriamycin-Fe3+ complex is reversible and activity is recovered upon solubilization of the particles. |
2(0,0,0,2) | Details |
| 40546 | Lorusso M, Capuano F, Boffoli D, Stefanelli R, Papa S: The mechanism of transmembrane delta muH+ generation in mitochondria by cytochrome c oxidase. Biochem J. 1979 Jul 15;182(1):133-47. In rat liver mitochondria treated with rotenone, N-ethylmaleimide or oligomycin the expected alkalinization caused by consumption for aerobic oxidation of ferrocyanide was delayed with respect to ferrocyanide oxidation, unless carbonyl p-trifluoromethoxyphenylhydrazone was present. 2. |
2(0,0,0,2) | Details |
| 9037024 | Villani G, Attardi G: In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1166-71. |
2(0,0,0,2) | Details |
| 1668635 | Kunz WS: Application of the theory of steady-state flux control to mitochondrial beta-oxidation. Biomed Biochim Acta. 1991;50(12):1143-57. The theory of steady-state flux control was applied to characterize the regulation of beta-oxidation flux in uncoupled rat liver mitochondria oxidizing in the presence of rotenone, and the / redox buffer. By titrations with inhibitors such as antimycin, myxothiazol, azide and 4-pentenoic acid, the flux control coefficients of the b-c1 complex, cytochrome c oxidase and thiolase, were determined experimentally. |
1(0,0,0,1) | Details |
| 12913298 | Sugio T, Fujii M, Takeuchi F, Negishi A, Maeda T, Kamimura K: Volatilization of mercury by an iron oxidation enzyme system in a highly mercury-resistant Acidithiobacillus ferrooxidans strain MON-1. Biosci Biotechnol Biochem. 2003 Jul;67(7):1537-44. oxidizing activities, 2,3,5,6-tetramethyl-p-phenylenediamine (TMPD) oxidizing activities and cytochrome c oxidase activities of strains SUG 2-2 and MON-1 were 26.3 and 41.9 microl O2 uptake/mg/min, 15.6 and 25.0 microl O2 uptake/mg/min, and 2.1 and 6.1 mU/mg, respectively. Mercury volatilized by the Fe (2+)-dependent mercury volatilization enzyme system of strain MON-1 was strongly inhibited by 1.0 mM but was not by 50 nM rotenone, 5 microM 2-n-heptyl-4--quinoline-N-oxide (HQNO), 0.5 microM antimycin A, or 0.5 microM myxothiazol, indicating that cytochrome c oxidase plays a crucial role in mercury volatilization of strain MON-1 in the presence of Fe2+. |
2(0,0,0,2) | Details |
| 2321971 | Bolter CJ, Chefurka W: Extramitochondrial release of peroxide from insect and mouse liver mitochondria using the respiratory inhibitors phosphine, myxothiazol, and antimycin and spectral analysis of inhibited cytochromes. Arch Biochem Biophys. 1990 Apr;278(1):65-72. The fumigant insecticide phosphine (PH3) is known to inhibit cytochrome c oxidase in vitro. Other respiratory inhibitors, antimycin, myxothiazol, and rotenone were used with insect mitochondria. |
2(0,0,0,2) | Details |
| 1488063 | Wu CM, Matsuoka T, Takemitsu M, Goto Y, Nonaka I: An experimental model of mitochondrial myopathy: -induced myopathy and administration. Muscle Nerve. 1992 Nov;15(11):1258-64. In skeletal muscles from rats treated with for 23 weeks, there were numerous ragged-red fibers and cytochrome-c oxidase (COX)-deficient fibers. Rotenone-sensitive -cytochrome-c reductase as well as COX activities were markedly reduced, while -cytochrome-c reductase was less severely, but significantly, affected. |
1(0,0,0,1) | Details |
| 2174736 | Modica-Napolitano JS, Joyal JL, Ara G, Oseroff AR, Aprille JR: Mitochondrial toxicity of cationic photosensitizers for photochemotherapy. Cancer Res. 1990 Dec 15;50(24):7876-81. With photoirradiation VB-BO was also shown to inhibit rotenone-sensitive -cytochrome c reductase activity, but it had no effect on -cytochrome c reductase activity. |
0(0,0,0,0) | Details |
| 6321463 | Grover AK, Kwan CY, Luchowski E, Daniel EE, Triggle DJ: Subcellular distribution of [3H] nitrendipine binding in smooth muscle. . J Biol Chem. 1984 Feb 25;259(4):2223-6. There was an excellent correlation between the distribution of [3H] nitrendipine binding determined at the nitrendipine concentrations of 0.138 and 1.38 nM, and the distribution of the plasma membrane markers K+-activated ouabain-sensitive p-nitrophenylphosphatase, 5'-nucleotidase, phosphodiesterase I, and Mg-ATPase, but not between the mitochondrial markers cytochrome c, oxidase, -dependent cytochrome c reductase, or rotenone-insensitive -dependent cytochrome c reductase or the putative endoplasmic reticulum marker -dependent cytochrome c reductase. |
0(0,0,0,0) | Details |
| 7866309 | Pastore D, Greco M, Petragallo VA, Passarella S: Increase in <--H+/e- ratio of the cytochrome c oxidase reaction in mitochondria irradiated with helium-neon laser. Biochem Mol Biol Int. 1994 Oct;34(4):817-26. A low, but statistically significant increase in the uptake was found, as polarographically measured, in the presence of rotenone and antimycin A, with and TMPD used as substrate pair. |
2(0,0,0,2) | Details |
| 7622786 | Goyal N, Srivastava VM: Oxidation and reduction of cytochrome c by mitochondrial enzymes of Setaria cervi. J Helminthol. 1995 Mar;69(1):13-7. A mitochondria-rich fraction isolated from the cuticle-hypodermis-muscle system of Setaria cervi, a bovine filarial parasite, possessed substrate-coupled cytochrome c reductases and cytochrome c oxidase in appreciable activities. All the three reductases exhibited marked sensitivity to rotenone and antimycin A. |
2(0,0,0,2) | Details |
| 6248693 | Weindruch RH, Cheung MK, Verity MA, Walford RL: Modification of mitochondrial respiration by aging and dietary restriction. Mech Ageing Dev. 1980 Apr;12(4):375-92. Old spleen mitochondria exhibited a grosser defect, showing a 40% decrease in the respiratory control index (RCI) for + rotenone)- supported respiration (the only substrate tested) due to a possible increase in state 4 rates. |
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| 9317382 | VÖ, Lkel S, Grieshaber M: Sulphide oxidation and oxidative phosphorylation in the mitochondria of the lugworm. J Exp Biol. 1997;200(Pt 1):83-92. consumption, ATP production and cytochrome c oxidase activity of isolated mitochondria from body-wall tissue of Arenicola marina were measured as a function of sulphide concentration, and the effect of inhibitors of the respiratory complexes on these processes was determined. Sulphide-induced ATP production was inhibited by antimycin, and oligomycin but not by rotenone or salicylhydroxamic acid. |
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| 15722109 | Capel F, Rimbert V, Lioger D, Diot A, Rousset P, Mirand PP, Boirie Y, Morio B, Mosoni L: Due to reverse electron transfer, mitochondrial H2O2 release increases with age in human vastus lateralis muscle although oxidative capacity is preserved. Mech Ageing Dev. 2005 Apr;126(4):505-11. Epub 2004 Dec 15. Isolated mitochondria were incubated in the presence of // with or without rotenone. Muscle fat oxidative capacity, citrate synthase, complex II, complex III, and cytochrome c oxidase activities were also measured. |
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| 19278021 | Song C, Scharf ME: Mitochondrial impacts of insecticidal esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster. Pest Manag Sci. 2009 Jun;65(6):697-703. RESULTS: In initial studies investigating inhibition of mitochondrial cytochrome c oxidase, two proven insecticidal materials (hydramethylnon and caused significant inhibition. and three positive control treatments (rotenone, antimycin A and induced cytochrome c release, verifying that is capable of causing mitochondrial disruption. |
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| 12515859 | Miyadera H, Shiomi K, Ui H, Yamaguchi Y, Masuma R, Tomoda H, Miyoshi H, Osanai A, Kita K, Omura S: Atpenins, potent and specific inhibitors of mitochondrial complex II - oxidoreductase). Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):473-7. Epub 2003 Jan 6. The use of specific and potent inhibitors of complex I -ubiquinone reductase) and complex III (ubiquinol-cytochrome c reductase), such as rotenone and antimycin, respectively, has allowed determination of the role of these enzymes in physiological processes. However, unlike complexes I, III, and IV (cytochrome c oxidase), there are few potent and specific inhibitors of complex II -ubiquinone reductase) that have been described. |
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| 9264320 | Dong Y, Berners-Price SJ, Thorburn DR, Antalis T, Dickinson J, Hurst T, Qiu L, Khoo SK, Parsons PG: Serine protease inhibition and mitochondrial dysfunction associated with cisplatin resistance in human tumor cell lines: targets for therapy. Biochem Pharmacol. 1997 Jun 1;53(11):1673-82. Unlike the HeLa clones, CI-80-13S cells were additionally sensitive to chloramphenicol, 1-methyl-4-phenylpyridinium ion (MPP+), rotenone, thenoyltrifluoroacetone (TTFA), and antimycin A, and showed poor reduction of 1-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium (MTT), suggesting a deficiency in NADH dehydrogenase and/or succinate dehydrogenase activities. The HeLa-S1a and HeLa-S1b clones, on the other hand, showed poor reduction of triphenyltetrazolium (TTC), indicative of low cytochrome c oxidase activity. |
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| 6513990 | Takamiya S, Furushima R, Oya H: Electron transfer complexes of Ascaris suum muscle mitochondria: I. Mol Biochem Parasitol. 1984 Oct;13(2):121-34. The enzyme preparation catalyzed the reduction of 1.68 mumol cytochrome c min-1 mg-1 protein at 25 degrees C with but not with and retained its sensitivity to rotenone, piericidin A and 2-heptyl-4-hydroxyquinoline-N-oxide as with the submitochondrial particles. The isolated complex I-III, essentially free of -cytochrome c reductase and cytochrome c oxidase, consisted of fourteen polypeptides with apparent molecular weights ranging from 76 000 to 12 000. |
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| 232293 | Gurtubay JI, Martinez J, Gutierrez-Arranz A, Goni FM: Assay of mitochondrial membrane-bound enzyme activities in the presence of triton X-100. Rev Esp Fisiol. 1979 Dec;35(4):395-400. cytochrome c reductase and rotenone-sensitive cytochrome c reductase activities are destroyed even a low detergent concentrations. |
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| 8627318 | Davey GP, Clark JB: Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J Neurochem. 1996 Apr;66(4):1617-24. Rotenone, myxothiazol, and KCN were used to titrate the activities of NADH:ubiquinone oxidoreductase (EC 1.6.5.3; complex I), ubiquinol:ferrocytochrome c oxidoreductase (EC 1.10.2.2; complex III), and cytochrome c oxidase (EC 1.9.3.1; complex IV ), respectively. |
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| 813630 | Collins N, Brown RH, Merrett MJ: Oxidative phosphorylation during metabolism in mitochondria from phototrophic Euglena gracilis. Biochem J. 1975 Sep;150(3):373-7. An antimycin A-sensitive but rotenone-insensitive -dependent uptake was demonstrated in isolated mitochondria. The partial reactions of -cytochrome c oxidoreductase and cytochrome c oxidase were demonstrated by using Euglena cytochrome c as exogenous electron acceptor/donor. |
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| 206463 | Moyle J, Mitchell P: Cytochrome c oxidase is not a proton pump. . FEBS Lett. 1978 Apr 15;88(2):268-72. We conclude that the reduction of O2 to 2 by cytochrome c oxidase of rat liver mitochondria involves the translocation of 4-from cytochrome c at the outer surface of the cristae membrane per O2 reduced and protonated by 4 H+ ions that enter the reaction domain from the inner aqueous phase. |
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| 7994564 | Chen CL, Sangiah S, Yu CA, Chen H, Berlin KD, Garrison GL, Scherlag BJ, Lazzara R: Effects of novel antiarrhythmic agents, BRB-I-28 and its derivatives, on the heart mitochondrial respiratory chain and sarcoplasmic reticulum Ca (2+)-ATPase. Res Commun Mol Pathol Pharmacol. 1994 Aug;85(2):193-208. The site of inhibition of BRB-I-28 and its derivatives on the respiratory chain was localized between flavoprotein n (FPn) and which is similar to the effect of rotenone and several other antiarrhythmic drugs such as amiodarone, etc. |
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| 8897462 | Whatley SA, Curti D, Marchbanks RM: Mitochondrial involvement in schizophrenia and other functional psychoses. . Neurochem Res. 1996 Sep;21(9):995-1004. Studies on -cytochrome c reductase showed that schizophrenics whether medicated or not had a reduced rotenone sensitive activity that was compensated for by increased rotenone insensitive activity. |
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| 17084831 | Shinde SB, Save VC, Patil ND, Mishra KP, Tendolkar AG: Impairment of mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. Clin Chim Acta. 2007 Feb;377(1-2):138-43. Epub 2006 Sep 26. The activities of rotenone-sensitive cytochrome c reductase (complexes I+III), cytochrome c oxidase (complex IV) and the ratio of I and III to II and III complexes (complex I) were significantly lower in TOF (p <0.001). |
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| 3039271 | Tanaka A, Morimoto T, Wakashiro S, Ikai I, Ozawa K, Orii Y: Kinetic alterations of cytochrome c oxidase in carbon tetrachloride induced cirrhotic rat liver. Life Sci. 1987 Aug 10;41(6):741-8. However, when the rate of uptake by mitochondria was measured in the presence of rotenone and tetramethyl-p-phenylene-diamine with as substrate, the specific activity in CCl4 treated rats was lower than that of normal rats (Vmax = 345 +/- 31 (e-/s/cytochrome aa3), as compared to Vmax = 408 +/- 21) in spite of the increased activity of cytochrome c oxidase. |
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| 9593899 | Almeida A, Heales SJ, Bolanos JP, Medina JM: neurotoxicity is associated with -mediated mitochondrial dysfunction and depletion. Brain Res. 1998 Apr 20;790(1-2):209-16. exposure (0.1 mM and 1 mM) followed by 24 h of incubation caused the inhibition of -cytochrome c reductase (20-25%) and cytochrome c oxidase (31%) activities in the surviving neurones, without affecting - reductase activity. |
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| 1602841 | Lemeshko VV, Belostotskaya LI: Decrease of phosphorylating oxidation and increase of heat producing oxidation in rat liver mitochondria during life-span prolongation of rats by calorie-restricted diet. Mech Ageing Dev. 1992 Mar 15;63(1):79-89. On the other hand, a significant increase in mitochondrial rotenone-insensitive oxidation and a higher liver mass/body mass ratio in rats under the calorie-restricted diet was established. |
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