| Name | PINK1 |
|---|---|
| Synonyms | BRPK; PARK6; PARK 6; PINK 1; PINK1; PTEN induced putative kinase 1; PTEN induced putative kinase protein 1; PTEN induced putative kinase 1s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18715146 | Ethell DW, Fei Q: Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal. 2009 Mar;11(3):529-40. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through members of the Bcl-2 family. Of the familial mutations identified thus far, two of the loci encode proteins associated with ubiquitin-proteasome degradation of misfolded proteins (Parkin and Uch-L1), and two encode proteins associated with mitochondria and oxidative stress (DJ-1 and PINK1). |
1(0,0,0,1) | Details |
| 16226715 | Deng H, Jankovic J, Guo Y, Xie W, Le W: Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun. 2005 Dec 2;337(4):1133-8. Epub 2005 Oct 6. Our results indicate that reduction in PINK1 expression can trigger apoptotic process that can be exacerbated by the presence of MPP (+) or rotenone. |
42(0,1,2,7) | Details |
| 20171192 | Um JW, Park HJ, Song J, Jeon I, Lee G, Lee PH, Chung KC: Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochem Biophys Res Commun. 2010 Mar 19;393(4):824-8. Epub 2010 Feb 18. Consistent with our previous findings from parkin knockout mice, rat models of PD -, rotenone-, or MG132-induced PD) were also associated with an increase in soluble and insoluble PINK1 levels as well as enhanced formation of parkin aggregates. |
11(0,0,1,6) | Details |
| 19492085 | Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Minguez A, Cookson MR: Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One. 2009 May 27;4(5):e5701. We also show that wild-type PINK1, but not recessive mutant or kinase dead versions, protects against rotenone-induced mitochondrial fragmentation whereas PINK1 deficient cells show lower mitochondrial connectivity. |
7(0,0,0,7) | Details |
| 19692353 | Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS: Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009 Nov 15;18(22):4390-404. Epub 2009 Aug 19. However, these flies were more sensitive to rotenone. |
2(0,0,0,2) | Details |
| 17010972 | Liang CL, Wang TT, Luby-Phelps K, German DC: Mitochondria mass is low in mouse substantia nigra neurons: implications for Parkinson's disease. Exp Neurol. 2007 Feb;203(2):370-80. Epub 2006 Sep 28. Many sporadic PD patients have a defect in mitochondria respiration, and some of the genes that cause PD are mitochondrial-related (e.g., PINK1, Parkin, DJ1). |
1(0,0,0,1) | Details |