| Name | Hsp70 |
|---|---|
| Synonyms | APG 2; APG2; HS24/P52; HSP70RY; HSPA 4; HSPA4; Heat shock 70 kDa protein 4; Heat shock 70 related protein APG 2… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18331584 | Liu F, Nguyen JL, Hulleman JD, Li L, Rochet JC: Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. J Neurochem. 2008 Apr 15. Expression of wild-type DJ-1 rescued primary dopaminergic neurons from toxicity elicited by rotenone, proteasome inhibitors, and mutant alpha-synuclein. In contrast, inhibition of alpha-synuclein toxicity by DJ-1 correlated with up-regulation of the stress-inducible form of Hsp70. |
1(0,0,0,1) | Details |
| 19406215 | Nagel F, Bahr M, Dietz GP: Tyrosine hydroxylase-positive amacrine interneurons in the mouse retina are resistant against the application of various parkinsonian toxins. Brain Res Bull. 2009 Jun 30;79(5):303-9. Epub 2009 May 3. Toxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), (6-OHDA), or rotenone have been used to induce degeneration of dopaminergic (DA) neurons in the nigrostriatal pathway and to reproduce pathological characteristics of Parkinson's disease (PD). Another membrane-permeable compound (Tat-Hsp70) could be delivered into the retina after i.p. application, suggesting that the blood-retina barrier (BRB) could be overcome after systemic application. |
1(0,0,0,1) | Details |
| 16313906 | Pan T, Li X, Xie W, Jankovic J, Le W: -mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells. FEBS Lett. 2005 Dec 19;579(30):6716-20. Epub 2005 Nov 21. We now show that attenuates rotenone (a potent complex I inhibitor)-induced apoptosis through the induction of heat shock protein 70, which may interact with apoptotic-protease-activating factor 1. |
1(0,0,0,1) | Details |