| Name | glucocorticoid receptors |
|---|---|
| Synonyms | GCCR; GCR; GR; GRL; Glucocorticoid receptor; NR3C1; Glucocorticoid receptors |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8068950 | Smets LA, Van den Berg J, Acton D, Top B, Van Rooij H, Verwijs-Janssen M: BCL-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis. Blood. 1994 Sep 1;84(5):1613-9. The cell lines all contained normal glucocorticoid receptors but differed widely in sensitivity to dexamethasone, ranging from very sensitive S49 lymphoma to completely resistant HL-60 acute leukemia cells. In resistant cell lines, sensitivity to dexamethasone was restored by the mitochondrial inhibitors rotenone and meta-iodobenzylguanidine. |
1(0,0,0,1) | Details |
| 7726559 | Pastorino JG, Wilhelm TJ, Glascott PA Jr, Kocsis JJ, Farber JL: Dexamethasone induces resistance to the lethal consequences of electron transport inhibition in cultured hepatocytes. Arch Biochem Biophys. 1995 Apr 1;318(1):175-81. Pretreatment of cultured rat hepatocytes with 1 microM dexamethasone protected against cell killing by 5 microM rotenone and 1 mM Protection by dexamethasone was blocked by 10 microM of glucocorticoid receptor antagonist, RU486, and by 1 microM of the inhibitor of protein synthesis, cycloheximide. |
1(0,0,0,1) | Details |
| 17123556 | Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN: Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007 Mar;52(3):827-35. Epub 2006 Nov 22. The protective effects of Rg1 was blocked by glucocorticoid receptor antagonist RU486, indicating that the action of Rg1 is mediated through glucocorticoid receptor (GR). |
1(0,0,0,1) | Details |
| 12628019 | Youssef J, Elbi C, Warren B, Yourtee D, Nagarur R, Molteni A, Cunningham ML, Badr M: Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated via enhanced serum levels: Molecular Fitting and Receptor Activation Studies. J Carcinog. 2003 Feb 14;2(1):2. |
0(0,0,0,0) | Details |