| Name | glutathione reductase |
|---|---|
| Synonyms | GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases… |
| Name | rotenone |
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| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6207776 | Satrustegui J, Richter C: The role of hydroperoxides as release agents in rat brain mitochondria. Arch Biochem Biophys. 1984 Sep;233(2):736-40. In the presence of and rotenone, hydroperoxide induces only a very limited oxidation of nucleotides, most probably due to the low level of peroxidase (EC 1.11.1.9) and glutathione reductase (EC 1.6.4.2) found in brain mitochondria. |
81(1,1,1,1) | Details |
| 8510014 | Rodeheaver DP, Schnellmann RG: Extracellular acidosis ameliorates metabolic-inhibitor-induced and potentiates oxidant-induced cell death in renal proximal tubules. J Pharmacol Exp Ther. 1993 Jun;265(3):1355-60. Cell death produced by the mitochondrial inhibitors rotenone, antimycin A, carbonyl p-trifluoromethoxyphenylhydrazone and oligomycin and by the ion exchangers valinomycin, nigericin and monensin was ameliorated by reducing extracellular pH (pHe) from 7.4 to 6.4. Because a decrease in pHe resulted in an increase in lipid peroxidation and in formation, and caused a decrease in peroxidase and glutathione reductase activities, the mechanism of this potentiation is most likely the result of an increase in free-radical production or a decrease in free-radical detoxification. |
1(0,0,0,1) | Details |
| 7532384 | Duval DL, Sieg DJ, Billings RE: Regulation of hepatic synthase by reactive intermediates and Arch Biochem Biophys. 1995 Feb 1;316(2):699-706. depletion by diethylmaleate, which conjugates 1,3-bis (chloroethyl)-1-nitrosourea (BCNU), a glutathione reductase inhibitor, or buthionine sulfoxamine, a synthesis inhibitor, abolishes or reduces NOS induction in TNF alpha-treated hepatocytes, whereas has little effect. NOS induction in TNF alpha-treated cells is reduced by rotenone, a mitochondrial complex 1 inhibitor. |
1(0,0,0,1) | Details |
| 19096101 | Takahashi T, Okuno M, Okamoto T, Kishi T: -dependent reductase is the main enzyme responsible for the reduction of non-mitochondrial in cells. Biofactors. 2008;32(1-4):59-70. We purified an -dependent reductase - reductase) in rat liver cytosol and compared its enzymatic properties with those of the other CoQ10 reductases such as acceptor oxidoreductase 1 (NQO1), dehydrogenase, thioredoxine reductase and glutathione reductase. |
1(0,0,0,1) | Details |
| 11124972 | Tretter L, Adam-Vizi V: Inhibition of Krebs cycle enzymes by peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting production under oxidative stress. J Neurosci. 2000 Dec 15;20(24):8972-9. The rotenone-induced increase in [NAD (P) H] fluorescence reflecting the amount of available for the respiratory chain was also diminished by H (2) O (2), and the effect exerted at small concentrations ((BCNU), an inhibitor of glutathione reductase. |
31(0,1,1,1) | Details |
| 15904944 | Molina-Jimenez MF, Sanchez-Reus MI, Cascales M, Andres D, Benedi J: Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Toxicol Appl Pharmacol. 2005 Dec 15;209(3):214-25. Thus, these considerations prompted us to investigate the way in which fraxetin and affect the endogenous antioxidant defense system, such as Mn and CuZn superoxide dismutase (MnSOD, CuZnSOD), catalase, glutathione reductase (GR), and peroxidase (GPx) on rotenone neurotoxicity in neuroblastoma cells. |
6(0,0,1,1) | Details |
| 1584202 | Peinado J, Florindo J, Lopez-Barea J: Glutathione reductase from Saccharomyces cerevisiae undergoes redox interconversion in situ and in vivo. Mol Cell Biochem. 1992 Mar 25;110(2):135-43. Greater changes were observed in the presence of 1.5 microM rotenone: enzymatic activity descended to 23% of the control value, while the /NAD+ and / ratios rose to 171% and 262% of their initial values, respectively. |
4(0,0,0,4) | Details |
| 14634020 | Zoccarato F, Cavallini L, Alexandre A: Respiration-dependent removal of exogenous H2O2 in brain mitochondria: inhibition by Ca2+. J Biol Chem. 2004 Feb 6;279(6):4166-74. Epub 2003 Nov 20. -dependent H2O2 is inhibited by rotenone, decreased DeltaPsi, as described previously, and by ruthenium red and / H2O2 removal in mitochondria is largely dependent on peroxidase and glutathione reductase. |
3(0,0,0,3) | Details |
| 7326006 | Holland MK, Storey BT: metabolism of mammalian spermatozoa. Biochem J. 1981 Aug 15;198(2):273-80. This endogenous rate was unaffected by rotenone, but stimulated 4-fold by antimycin A. Rabbit spermatozoa have peroxidase and glutathione reductase activities, but these seem to play little role in removal of H (2) O (2) generated. |
1(0,0,0,1) | Details |
| 8403080 | Snyder JW, Alexander GM, Ferraro TN, Grothusen JR, Farber JL: N-methyl-4-phenylpyridinium (MPP+) potentiates the killing of cultured hepatocytes by catecholamines. Chem Biol Interact. 1993 Sep;88(2-3):209-23. The killing of cultured hepatocytes by and was enhanced following inhibition of glutathione reductase by 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU), a manipulation known to sensitize such cells to an oxidative stress. The toxicity of catecholamines was also potentiated by the mitochondrial site I (NADH dehydrogenase) inhibitor rotenone. |
1(0,0,0,1) | Details |
| 8394729 | Silva JM, O'Brien PJ: Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions. Br J Cancer. 1993 Sep;68(3):484-91. The increased respiration was inhibited by the respiratory inhibitors KCN and antimycin A but not by rotenone. SR 4233 however induced -resistant respiration, an indicator of redox cycling mediated oxidative stress and became cytotoxic if hepatocyte catalase or glutathione reductase was inactivated. |
1(0,0,0,1) | Details |
| 6229605 | Vitorica J, Machado A, Satrustegui J: Age-dependent variations in peroxide-utilizing enzymes from rat brain mitochondria and cytoplasm. J Neurochem. 1984 Feb;42(2):351-6. peroxidase and glutathione reductase distributions indicate that both enzymes are located in the cytoplasm and in the matrix space of "synaptosomal" and "free" mitochondria. On the other hand, catalase distribution parallels that of -cytochrome c reductase (rotenone-insensitive), and appears to be associated with the outer membrane of brain mitochondria. |
1(0,0,0,1) | Details |
| 15710606 | Zoccarato F, Toscano P, Alexandre A: -derived dopaminochrome promotes H (2) O (2) release at mitochondrial complex I: stimulation by rotenone, control by Ca (2+), and relevance to Parkinson disease. J Biol Chem. 2005 Apr 22;280(16):15587-94. Epub 2005 Feb 14. Mitochondrial removal of H (2) O (2) monoamine, formed by either oxidase activity or DACHR, was performed largely by peroxidase and glutathione reductase, which were negatively regulated by low intramitochondrial Ca (2+) levels. |
1(0,0,0,1) | Details |
| 6317750 | Kiyotaki C, Peisach J, Bloom BR: metabolism in cloned macrophage cell lines: dependence of production, metabolic and spectral analysis. J Immunol. 1984 Feb;132(2):857-66. O2- production in J774.16 cells was inhibited by some agents known to block mitochondrial electron transport before such as rotenone and tetrathiafulvalene, whereas antimycin A enhanced O2- production. |
0(0,0,0,0) | Details |
| 3020812 | Moore GA, O'Brien PJ, Orrenius S: -induced Ca2+ release from rat-liver mitochondria is caused by NAD (P) H oxidation. Xenobiotica. 1986 Sep;16(9):873-82. Incubation of rat-liver mitochondria with in the presence of and rotenone resulted in rapid and NAD (P) H oxidation followed by Ca2+ release and mitochondrial swelling. |
0(0,0,0,0) | Details |
| 1540380 | Kinnula VL, Whorton AR, Chang LY, Crapo JD: Regulation of peroxide generation in cultured endothelial cells. . Am J Respir Cell Mol Biol. 1992 Feb;6(2):175-82. Furthermore, inhibition of the mitochondrial respiratory chain (rotenone, antimycin A) or microsomal cytochrome P-450 (8-methoxypsoralen) did not change extracellular H2O2 release or intracellular H2O2 production (at peroxisomes) by endothelial cells or cells in which glutathione reductase was inactivated. |
0(0,0,0,0) | Details |
| 9377792 | Ribeiro SM, Campello AP, Nascimento AJ, Kluppel ML: Effect of amiodarone (AMD) on the antioxidant enzymes, lipid peroxidation and mitochondrial metabolism. Cell Biochem Funct. 1997 Sep;15(3):145-52. The results confirm the effects of AMD on complex I and permit the placing of this drug in class A of the classification of Knobeloch, together with rotenone, amytal and chaotropic agents. |
0(0,0,0,0) | Details |