| Name | caspase 8 |
|---|---|
| Synonyms | Apoptotic cysteine protease; Apoptotic protease Mch 5; CAP 4; CAP4; CASP 8; CASP8; CASP8 protein; Caspase 8… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15764812 | Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A: -induced cell death in human prostate cancer cells is initiated by reactive species. J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11. In addition, SFN treatment resulted in an increase in the level of Fas, activation of caspase-8, and cleavage of Bid. The SFN-induced ROS generation was significantly attenuated on pretreatment with mitochondrial respiratory chain complex I inhibitors, including diphenyleneiodonium and rotenone. |
1(0,0,0,1) | Details |
| 20226830 | Cuello S, Goya L, Madrid Y, Campuzano S, Pedrero M, Bravo L, Camara C, Ramos S: Molecular mechanisms of methylmercury-induced cell death in human HepG2 cells. Food Chem Toxicol. 2010 Mar 10. This feature was preceded by an enhancement in the caspase-9 activity (2h), whereas caspase-8 activity remained unchanged. |
1(0,0,0,1) | Details |
| 16157303 | Nutku E, Hudson SA, Bochner BS: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun. 2005 Oct 28;336(3):918-24. Siglec-8 crosslinking induced rapid cleavage of caspase-3, caspase-8, and caspase-9 in eosinophils. Rotenone and antimycin, inhibitors of mitochondrial respiratory chain components, completely inhibited apoptosis. |
2(0,0,0,2) | Details |
| 18402771 | Lee J, Huang MS, Yang IC, Lai TC, Wang JL, Pang VF, Hsiao M, Kuo MY: Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis. Biochem Biophys Res Commun. 2008 Jun 20;371(1):33-8. Epub 2008 Apr 8. Western blotting showed activation of both the caspase-8 and caspase-9 pathways, which differed from previous studies conducted in other cell types. |
1(0,0,0,1) | Details |
| 9989825 | Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML: peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive species and the activation of NF-kappaB. Oncogene. 1999 Jan 21;18(3):747-57. Inhibition of the mitochondrial permeability transition by bongkrekic acid (BA), or interference with the mitochondrial electron transport system by rotenone or prevented the cytotoxic effect of H2O2. |
0(0,0,0,0) | Details |
| 11078377 | Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I: Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S201-4. In this study, we applied mitochondrial inhibitors, such as rotenone, and antimycin A, which inhibit mitochondrial function at different sites of the mitochondrial respiratory chain, to cardiomyocytes. |
0(0,0,0,0) | Details |