Protein Information

Name pyrroline 5 carboxylate reductase (protein family or complex)
Synonyms Pyrroline 5 carboxylate reductase; Pyrroline 5 carboxylate reductases

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
3768405 Hagedorn CH: Demonstration of a NADPH-linked delta 1-pyrroline-5-carboxylate-proline shuttle in a cell-free rat liver system. Biochim Biophys Acta. 1986 Oct 29;884(1):11-7.

A phosphate-free buffer with high concentrations of triethanolamine and 2-mercaptoethanol prevented the cold inactivation of pyrroline-5-carboxylate reductase (EC 1.5.1.2) in liver extracts.
Rotenone was required for maximal activity, suggesting that inhibition of delta 1-pyrroline-5-carboxylate efflux would be required for significant shuttle activity in vivo.
2(0,0,0,2) Details