Protein Information

Name catechol O methyltransferase
Synonyms COMT; COMT protein; Catechol O methyltransferase; Catechol O methyltransferase isoform MB COMT; MB COMT; COMT proteins; Catechol O methyltransferases; Catechol O methyltransferase isoform MB COMTs

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16774923 Ogburn KD, Figueiredo-Pereira ME: Cytoskeleton/endoplasmic reticulum collapse induced by prostaglandin J2 parallels centrosomal deposition of ubiquitinated protein aggregates. J Biol Chem. 2006 Aug 11;281(32):23274-84. Epub 2006 Jun 14.

This aberrant protein deposition, triggered by a product of inflammation, may be common to other compounds that disrupt microtubules and induce protein aggregation, such as MPP+ and rotenone, found to be associated with neurodegeneration.
This cyclopentenone prostaglandin triggered endoplasmic reticulum (ER) collapse and the redistribution of ER proteins, such as calnexin and catechol-O-methyltransferase, into a large centrosomal aggregate containing ubiquitinated proteins and alpha-synuclein.		 1(0,0,0,1) Details