Protein Information

Name pyrophosphatase
Synonyms Cytosolic inorganic pyrophosphatase; IOPPP; Inorganic pyrophosphatase; Inorganic pyrophosphatase 1; PP; PP1; PPA 1; PPA1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
14665431 Feldkamp T, Kribben A, Roeser NF, Senter RA, Kemner S, Venkatachalam MA, Nissim I, Weinberg JM: Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules. Am J Physiol Renal Physiol. 2004 Apr;286(4):F749-59. Epub 2003 Dec 9.

Extensive degradation of cytosolic and mitochondrial NAD (H) pools occurred during either hypoxia or severe electron transport inhibition by rotenone, with patterns of metabolite accumulation consistent with catabolism by both NAD+ glycohydrolase and pyrophosphatase.
81(1,1,1,1) Details
3196710 Schonfeld P, Wojtczak AB, Geelen MJ, Kunz W, Wojtczak L: On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids. Biochim Biophys Acta. 1988 Dec 7;936(3):280-8.

Addition of octanoate in the presence of fluoride (inhibitor of pyrophosphatase) produces intramitochondrial accumulation of pyrophosphate, even under conditions when oxidation of octanoate is prevented by rotenone.
31(0,1,1,1) Details
4146799 Moyle J, Mitchell P: The proton-translocating nicotinamide-adenine dinucleotide (phosphate) transhydrogenase of rat liver mitochondria. Biochem J. 1973 Mar;132(3):571-85.

The NAD-linked isocitrate dehydrogenase activity was destroyed by an endogenous autolytic system or by added nucleotide pyrophosphatase, and was restored by a catalytic amount of NADP. 2.
During oxidation of isocitrate by acetoacetate in intact, anaerobic, mitochondria via the rhein-sensitive, but rotenone- and arsenite-insensitive, NAD (P) transhydrogenase, measurements of the rates of carbonyl cyanide p-trifluoromethoxyphenylhydrazone-sensitive and carbonyl cyanide p-trifluoromethoxyphenylhydrazone-insensitive pH change in the presence of various oxoglutarate/isocitrate concentration ratios gave an --> H (+)/2e (-) quotient of 1.94+/-0.12 for outward proton translocation by the NAD (P) transhydrogenase. 4.
1(0,0,0,1) Details