| Name | calpain inhibitor |
|---|---|
| Synonyms | BS 17; CAST; Calpain inhibitor; Calpastatin; Calpastatin isoform a; Heart type calpastatin; Sperm BS 17 component; Calpain inhibitors… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18991878 | Samantaray S, Butler JT, Ray SK, Banik NL: Extranigral neurodegeneration in Parkinson's disease. Ann N Y Acad Sci. 2008 Oct;1139:331-6. We examined the mechanisms of calpain-mediated neuronal death in differentiated spinal cord motoneuron cultures following exposure to the active parkinsonian toxins 1-methyl-4-phenyl-pyridinium ion (MPP (+)) and rotenone and also tested the neuroprotective efficacy of calpeptin, a calpain inhibitor, in these cell culture models of experimental parkinsonism. |
31(0,1,1,1) | Details |
| 8882611 | Kengatharan M, De Kimpe SJ, Thiemermann C: Analysis of the signal transduction in the induction of synthase by lipoteichoic acid in macrophages. Br J Pharmacol. 1996 Mar;117(6):1163-70. Inhibitors of the activation of the nuclear transcription factor NF-kappa B such as pyrrolidine dithiocarbamate (PDTC; an antioxidant and a metal chelator), butylated hydroxyanisole (BHA; an antioxidant), L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), calpain inhibitor I (both I kappa B-protease inhibitors), or rotenone (an antioxidant which inhibits electron transport) prevented the nitrite formation stimulated by LTA. |
31(0,1,1,1) | Details |
| 18673214 | Samantaray S, Ray SK, Banik NL: Calpain as a potential therapeutic target in Parkinson's disease. CNS Neurol Disord Drug Targets. 2008 Jun;7(3):305-12. Studies in rodent and cell culture models of PD suggest that treatment with calpain inhibitors (e.g., calpeptin, MDL-28170) can prevent neuronal death and restore functions. In this review, we summarize the evidence in support of involvement of calpain, a Ca (2+)-activated non-lysosomal protease, in spinal cord degeneration in two models of experimental parkinsonism induced by the neurotoxin 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine and also the environmental toxin rotenone. |
1(0,0,0,1) | Details |
| 10704144 | Ruetten H, Thiemermann C, Perretti M: Upregulation of ICAM-1 expression on J774.2 macrophages by endotoxin involves activation of NF-kappaB but not protein tyrosine kinase: comparison to induction of iNOS. Mediators Inflamm. 1999;8(2):77-84. The upregulation of ICAM-1 expression on J774.2 macrophages caused by LPS was significantly inhibited by pretreatment of the cells with inhibitors of the activation of the nuclear transcription factor NF-kappaB, such as L-1-tosylamido-2-phenylethylchloromethyl ketone (TPCK), pyrrolidine dithiocarbamate (PDTC), rotenone or calpain inhibitor I, but not by the kinase inhibitors, tyrphostin AG126 or |
0(0,0,0,0) | Details |