| Name | neurotrophic factor |
|---|---|
| Synonyms | HDNF; Neurotrophic factor; NT3; NGF 2; NGF2; NT 3; NTF 3; NTF3… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16887804 | Jiang Q, Yan Z, Feng J: Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem. 2006 Sep 29;281(39):29391-400. Epub 2006 Aug 3. Moreover, other neurotrophic factors such as brain-derived neurotrophic factor and glia cell line-derived neurotrophic factor also reduced rotenone- or colchicine-induced microtubule depolymerization and death of TH (+) through a MEK-dependent mechanism. |
81(1,1,1,1) | Details |
| 19442875 | Falk T, Zhang S, Sherman SJ: Pigment epithelium derived factor (PEDF) is neuroprotective in two in vitro models of Parkinson's disease. Neurosci Lett. 2009 Jul 17;458(2):49-52. Epub 2009 Apr 11. We conclude that the neurotrophic factor PEDF, produced from RPE cells, can improve neuronal survival in models of PD, and plan to test if this effect can be observed using in vivo models of PD following RPE transplantation. This was shown in (1) rotenone and (2) (6-OHDA) in vitro models. |
1(0,0,0,1) | Details |
| 15748169 | Kaur N, Lu B, Monroe RK, Ward SM, Halvorsen SW: Inducers of oxidative stress block ciliary neurotrophic factor activation of Jak/STAT signaling in neurons. J Neurochem. 2005 Mar;92(6):1521-30. These results suggest that disruption of neurotrophic factor signaling by mediators of oxidative stress may contribute to the neuronal damage observed in neurodegenerative diseases and significantly affect the utility of CNTF-like factors as therapeutic agents in preventing nerve cell death. Also, two other mediators of oxidative stress, and rotenone, inhibited CNTF signaling. |
1(0,0,0,1) | Details |