| Name | PSST |
|---|---|
| Synonyms | CI 20kD; Complex I 20kD; My017 protein; NADH dehydrogenase (ubiquinone) Fe S protein 7 (20kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase Fe S protein 7; NADH ubiquinone oxidoreductase 20 kDa subunit; NADH ubiquinone oxidoreductase Fe S protein 7 variant; NDUFS 7… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11418099 | Schuler F, Casida JE: Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta. 2001 Jul 2;1506(1):79-87. |
5(0,0,0,5) | Details |
| 10097178 | Schuler F, Yano T, Di Bernardo S, Yagi T, Yankovskaya V, Singer TP, Casida JE: -quinone oxidoreductase: PSST subunit couples electron transfer from iron- cluster N2 to Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4149-53. Complex I and NDH-1 are very sensitive to inhibition by a variety of structurally diverse toxicants, including rotenone, piericidin A, bullatacin, and pyridaben. |
4(0,0,0,4) | Details |
| 11695186 | Schuler F, Casida JE: The insecticide target in the PSST subunit of complex I. . Pest Manag Sci. 2001 Oct;57(10):932-40. |
3(0,0,0,3) | Details |
| 11358527 | Fang J, Wang Y, Beattie DS: Isolation and characterization of complex I, rotenone-sensitive oxidoreductase, from the procyclic forms of Trypanosoma brucei. Eur J Biochem. 2001 May;268(10):3075-82. Four polypeptides of the partially purified enzyme were identified as the homologous subunits of complex I (51 kDa, PSST, TYKY, and ND4) by immunoblotting with antibodies raised against subunits of Paracoccus denitrificans and against synthetic peptides predicted from putative complex I subunit genes encoded by mitochondrial and nuclear T. brucei DNA. |
2(0,0,0,2) | Details |
| 18486594 | Fendel U, Tocilescu MA, Kerscher S, Brandt U: Exploring the inhibitor binding pocket of respiratory complex I. . Biochim Biophys Acta. 2008 Jul-Aug;1777(7-8):660-5. Epub 2008 Apr 30. Guided by the X-ray structure of the peripheral arm of complex I from Thermus thermophilus we have generated a large collection of site-directed mutants in the yeast Yarrowia lipolytica targeting the proposed and inhibitor binding pocket of this huge multiprotein complex at the interface of the 49-kDa and PSST subunits. Many mutations around the domain of the 49-kDa subunit that is homologous to the [NiFe] centre binding region of hydrogenase conferred resistance to DQA (class I/type A) and rotenone (class II/type B) indicating a wider overlap of the binding sites for these two types of inhibitors. |
1(0,0,0,1) | Details |
| 14699012 | Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN: oxidase activity of rat cardiac sarcoplasmic reticulum regulates -induced release. Circ Res. 2004 Mar 5;94(4):478-86. Epub 2003 Dec 29. A significant contribution by mitochondria was excluded as oxidation by SR exhibited > 9-fold higher catalytic activity (8.8 micromol/mg protein per minute) in the absence of exogenous mitochondrial complex I or complex III (cytochrome c) electron acceptors, but was inhibited by rotenone and pyridaben (IC50=2 to 3 nmol/L), antimycin A (IC50=13 nmol/L), and diphenyleneiodonium (IC50=28 micromol/L). Cardiac junctional SR treated with [3H](trifluoromethyl) diazirinyl-pyridaben specifically labeled a single 23-kDa PSST-like protein. |
1(0,0,0,1) | Details |
| 7957254 | Finel M, Majander AS, Tyynela J, De Jong AM, Albracht SP, Wikstrom M: Isolation and characterisation of subcomplexes of the mitochondrial NADH:ubiquinone oxidoreductase (complex I). Eur J Biochem. 1994 Nov 15;226(1):237-42. E. (1992) Biochemistry 31, 11425-11434], but it retains the 75-, 51-, 49-, 30-, 24-, 23- (TYKY) and 20-kDa (PSST) subunits, which are suggested to form a functional core that comprises the EPR-detectable Fe-S clusters 1-4, and FMN. In addition, the Q-1 reductase activity of all the subcomplexes is insensitive to rotenone. |
1(0,0,0,1) | Details |