| Name | cytochrome c |
|---|---|
| Synonyms | CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 813630 | Collins N, Brown RH, Merrett MJ: Oxidative phosphorylation during metabolism in mitochondria from phototrophic Euglena gracilis. Biochem J. 1975 Sep;150(3):373-7. An antimycin A-sensitive but rotenone-insensitive -dependent uptake was demonstrated in isolated mitochondria. The partial reactions of -cytochrome c oxidoreductase and cytochrome c oxidase were demonstrated by using Euglena cytochrome c as exogenous electron acceptor/donor. |
1(0,0,0,1) | Details |
| 19647776 | Inden M, Kitamura Y, Tamaki A, Yanagida T, Shibaike T, Yamamoto A, Takata K, Yasui H, Taira T, Ariga H, Taniguchi T: Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice. Neurochem Int. 2009 Dec;55(8):760-7. Epub 2009 Aug 6. In addition, pramipexole inhibited the in vitro oligomerization of human wild-type alpha-synuclein by H (2) O (2) plus cytochrome c. |
1(0,0,0,1) | Details |
| 16531806 | Lijnen P, Papparella I, Petrov V, Semplicini A, Fagard R: Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive species. J Hypertens. 2006 Apr;24(4):757-66. NAD (P) H-dependent production was assayed as superoxide dismutase-inhibitable cytochrome c reduction. Rotenone, allopurinol, indomethacin, nordihydroguiaretic acid, ketoconazole and nitro- (inhibitors of mitochondrial NAD (P) H oxidase, xanthine oxidase, cyclooxygenase, lipoxygenase, cytochrome P450 oxygenase and synthase, respectively) did not affect the angiotensin II-induced collagen production. |
1(0,0,0,1) | Details |
| 2158476 | Meier B, Radeke HH, Selle S, Raspe HH, Sies H, Resch K, Habermehl GG: Human fibroblasts release reactive species in response to treatment with synovial fluids from patients suffering from arthritis. Free Radic Res Commun. 1990;8(3):149-60. The primary radical produced was O2- as determined by ESR spin trapping and cytochrome c reduction. Radical production and light emission were not altered either by or allopurinol, nor by azide, or rotenone. |
1(0,0,0,1) | Details |
| 190208 | Dailey HA Jr, Lascelles J: Reduction of iron and synthesis of by Spirillum itersonii and other organisms. J Bacteriol. 1977 Feb;129(2):815-20. The effects of respiratory inhibitors suggested that reduction of iron occurs at one or more sites on the respiratory chain before cytochrome c. |
1(0,0,0,1) | Details |
| 202411 | Thayer WS: Adriamycin stimulated formation in submitochondrial particles. Chem Biol Interact. 1977 Dec;19(3):265-78. formation was detected by uptake, by the cooxidation of to adrenochrome and by the reduction of acetylated cytochrome c. Rotenone-insensitive oxidation of by the mitochondrial respiratory chain in the presence of caused the formation of approx 4 nmol of per min/mg of protein. |
1(0,0,0,1) | Details |
| 17006955 | Saunders R, Szymczyk KH, Shapiro IM, Adams CS: Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. J Cell Biochem. 2007 Feb 15;100(3):703-15. Western blot analysis indicated migration of cytochrome-c and Smac/DIABLO from mitochondria to the cytoplasm. Inhibition of either the electron transfer chain (with antimycin a and rotenone), or the activation of a MMP transition (with bongkrekic acid) inhibited apoptosis in a dose-dependent manner. |
1(0,0,0,1) | Details |
| 4977982 | Jurtshuk P, Bednarz AJ, Zey P, Denton CH: oxidation by the electron transport fraction of Azotobacter vinelandii. J Bacteriol. 1969 Jun;98(3):1120-7. Minor inhibitory effects were noted with the inhibitors 4,4,4-trifluoro-1-(2-thienyl)-1,3- rotenone, and Amytal. Cytochrome c was a poor electron acceptor. |
1(0,0,0,1) | Details |
| 12962151 | Tsuruga M, Dang Y, Shiono Y, Oka S, Yamazaki Y: Differential effects of and three hydrophilic antioxidants on the actinomycin D-induced and colcemid-accelerated apoptosis in human leukemia CMK-7 cell line. Mol Cell Biochem. 2003 Aug;250(1-2):131-7. Western blot analysis showed that the proteolytic cleavage of procaspase-9 and procaspase-3 were both inhibited when VE was added with AD or when was added with CL, and that the cytochrome c liberation was suppressed by both antioxidants. |
1(0,0,0,1) | Details |
| 16386870 | Reiser G, Schonfeld P, Kahlert S: Mechanism of toxicity of the branched-chain fatty acid a marker of Refsum disease, in astrocytes involves mitochondrial impairment. Int J Dev Neurosci. 2006 Apr-May;24(2-3):113-22. Epub 2006 Jan 18. Moreover, released cytochrome c from mitochondria. |
1(0,0,0,1) | Details |
| 20187293 | Liu WH, Chang LS: Reactive species and p38 mitogen-activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin-gamma. J Cell Mol Med. 2009 Aug;13(8B):1695-705. Inhibitors of electron transport (rotenone and antimycin A) or inhibitor of mitochondrial permeability transition pore (cyclosporine A) reduced the effect of toxin- on ROS generation, loss of deltapsim and cytochrome c release. |
82(1,1,1,2) | Details |
| 16917840 | Imamura K, Takeshima T, Kashiwaya Y, Nakaso K, Nakashima K: D- protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. J Neurosci Res. 2006 Nov 1;84(6):1376-84. Whereas rotenone caused the loss of mitochondrial membrane potential, released cytochrome c into the cytosol, and reduced cytochrome c content in mitochondria, addition of bHB blocked this toxic effect. bHB also attenuated the rotenone-induced activation of caspase-9 and caspase-3. |
81(1,1,1,1) | Details |
| 19023968 | Grishina EV, Khaustova YV, Pogorelova VG, Pogorelov AG, Kuz'mich MK, Maevskii EI: Accelerated utilization of lactate under the effect of hypoxen after intensive exercise. Bull Exp Biol Med. 2008 Feb;145(2):198-201. The in vivo effects are in line with hypoxen capacity to accelerate in vitro oxidation of exogenous in mitochondria by the non-rotenone-dependent pathway realized with participation of cytochrome C. |
31(0,1,1,1) | Details |
| 11124957 | Grivennikova VG, Kapustin AN, Vinogradov AD: Catalytic activity of NADH-ubiquinone oxidoreductase (complex I) in intact mitochondria. evidence for the slow active/inactive transition. J Biol Chem. 2001 Mar 23;276(12):9038-44. Epub 2000 Dec 21. The matrix proteins were retained in alamethicin-treated mitochondria as judged by their high rotenone-sensitive -cytochrome c reductase activity in the presence of added NAD (+). |
7(0,0,1,2) | Details |
| 10874983 | Lofrumento DD, Panaro MA, Mitolo V: Modulation between aerobic and anaerobic metabolism in the mutant cell line CdtR-Q. Boll Soc Ital Biol Sper. 1998 Jul-Aug;74(7-8):67-74. On the other hand, -cytochrome c oxido-reductase activity, insensitive to rotenone, is more than doubled in Don Q. |
7(0,0,1,2) | Details |
| 207318 | Backstrom D, Lorusso M, Anderson K, Ehrenberg A: Characterization of the iron- protein of the mitochondrial outer membrane partially purified from beef kidney cortex. Biochim Biophys Acta. 1978 May 10;502(2):276-88. A functional relationship to the rotenone-insensitive -cytochrome c oxidoreductase in the mitochondrial outer membrane is suggested. |
6(0,0,1,1) | Details |
| 6086170 | Kramer JH, Mak IT, Weglicki WB: Differential sensitivity of canine cardiac sarcolemmal and microsomal enzymes to inhibition by free radical-induced lipid peroxidation. Circ Res. 1984 Jul;55(1):120-4. Sarcolemmal and microsomal membranes prepared from adult canine cardiac myocytes (sarcolemmal Na+, K+-ATPase = 71.8 mumol/mg per hr and microsomal rotenone-insensitive cytochrome c reductase = 114 mumol/mg per hr) were each preincubated at 37 degrees C in the presence of a free radical generating system consisting of and Fe - loss of the Na+, K+-ATPase and reductase activities, as well as the associated increases in lipid peroxidation, measured by malondialdehyde formation, were temporally correlated in both systems. |
6(0,0,1,1) | Details |
| 2831981 | Kier AB, Parker MT, Schroeder F: Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice. Biochim Biophys Acta. 1988 Mar 3;938(3):434-46. When compared to the -fed tumor cells, the specific activities of three mitochondrial enzymes, namely dependent, rotenone insensitive -dependent, and rotenone sensitive -dependent cytochrome-c reductase, were significantly increased in the analogue-supplemented cells. |
6(0,0,1,1) | Details |
| 14570377 | Knorre DA, Dedukhova VI, Vyssokikh MY, Mokhova EN: Cyclosporin A-sensitive cytochrome c release and activation of external pathway of oxidation in liver mitochondria due to pore opening by acidification of -containing incubation medium. Biosci Rep. 2003 Apr-Jun;23(2-3):67-75. Acidification of a high incubation medium from pH 7.4 to 6.5 promotes increase in rates of oxidation and exogenous oxidation via external (rotenone-and myxothiazol-resistant) pathway by factors 2 and 2.3 respectively. |
4(0,0,0,4) | Details |
| 3039271 | Tanaka A, Morimoto T, Wakashiro S, Ikai I, Ozawa K, Orii Y: Kinetic alterations of cytochrome c oxidase in carbon tetrachloride induced cirrhotic rat liver. Life Sci. 1987 Aug 10;41(6):741-8. There was a slight increase in Km for cytochrome c from 5.63 +/- 0.08 microM to 7.79 +/- 0.80. However, when the rate of uptake by mitochondria was measured in the presence of rotenone and tetramethyl-p-phenylene-diamine with as substrate, the specific activity in CCl4 treated rats was lower than that of normal rats (Vmax = 345 +/- 31 (e-/s/cytochrome aa3), as compared to Vmax = 408 +/- 21) in spite of the increased activity of cytochrome c oxidase. |
1(0,0,0,1) | Details |
| 16658636 | Day DA, Wiskich JT: The Oxidation of and Exogenous by Isolated Plant Mitochondria. Plant Physiol. 1974 Jan;53(1):104-109. In intact mitochondria, -cytochrome c reductase activity was only slightly inhibited by antimycin A. oxidation was sensitive to both rotenone and antimycin A and gave ADP/O values of 2.4 to 2.9. |
1(0,0,0,1) | Details |
| 3341744 | Carabez A, Sandoval F: The action of the sesquiterpenic perezone, on electron transport in biological membranes. Arch Biochem Biophys. 1988 Jan;260(1):293-300. Perezone at 50 microM inhibits mitochondrial electron transport through a process which differs from that of rotenone, amytal, and Antimycin A. It mediates electron transport from a reaction center preparation isolated from Rhodopseudomonas sphaeroides and added cytochrome c. |
1(0,0,0,1) | Details |
| 12800192 | Weitsman GE, Ravid A, Liberman UA, Koren R: enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive species and mitochondria. Int J Cancer. 2003 Aug 20;106(2):178-86. The hormone augmented the drop in DeltaPsi and release of cytochrome c from mitochondria, induced by TNFalpha. The effect of on DeltaPsi was mimicked by rotenone, which increased both the drop in DeltaPsi and caspase activation induced by TNFalpha. |
1(0,0,0,1) | Details |
| 11710721 | Sambo P, Baroni SS, Luchetti M, Paroncini P, Dusi S, Orlandini G, Gabrielli A: Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive species generation through the oxidase complex pathway. Arthritis Rheum. 2001 Nov;44(11):2653-64. This suppression was not seen with rotenone, a mitochondrial oxidase inhibitor, or allopurinol, a xanthine oxidase inhibitor. Levels of O2- and H2O2 released from fibroblasts were estimated by the superoxide dismutase (SOD)-inhibitable cytochrome c reduction and assays, respectively. |
1(0,0,0,1) | Details |
| 2556998 | Meier B, Radeke HH, Selle S, Younes M, Sies H, Resch K, Habermehl GG: Human fibroblasts release reactive species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J. 1989 Oct 15;263(2):539-45. The primary radical produced was O2.- as determined by e.s.r. spin trapping and cytochrome c reduction. Radical production and light emission were not altered by either or allopurinol, nor by azide, or rotenone. |
1(0,0,0,1) | Details |
| 171290 | Baumrucker CR, Keenan TW: Membranes of mammary gland. J Dairy Sci. 1975 Sep;58(9):1282-7. These marker enzymes include: Succinate dehydrogenase (mitochondria), cytochrome c reductase and, to a lesser extent, retenone insensitive cytochrome c reductase (endoplasmic reticulum), galactosyl transferase (Golgi apparatus), 5'-nucleotidase (plasma membranes), oxidase (microbodies), and acid phosphatase (lysosomes). Rotenone sensitive cytochrome c reductase and -stimulated triphosphatase were widely distributed among subcellular fractions and are not valid marker enzymes. |
1(0,0,0,1) | Details |
| 18836818 | Kumar B, Kumar A, Pandey BN, Mishra KP, Hazra B: Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. Mol Cell Biochem. 2009 Jan;320(1-2):185-95. Epub 2008 Oct 4. Taken together, the results of our study clearly suggested that the apoptosis induced by D7 would involve alteration of MPT, peroxidation, migration of Bax from cytosol to mitochondria, decreased expression of Bcl-2, and release of cytochrome c, indicating oxidative mechanism at the mitochondrial level in the tumor cells. |
1(0,0,0,1) | Details |
| 7622333 | Armson A, Grubb WB, Mendis AH: Strongyloides ratti: mitochondrial enzyme activities of the classical electron transport pathway in the infective (L3) larvae. Int J Parasitol. 1995 Feb;25(2):257-60. Submitochondrial particles prepared from S. ratti L3 larvae exhibited -oxidase (NOX), -ferricyanide reductase (NFR), -cytochrome-c-reductase (NCR), -cytochrome-c-reductase (SCR), and cytochrome-aa3-oxidase activities of 2.1 +/- 0.3, 8.9 +/- 1.3, 0.6 +/- 0.1., 1.0 +/- 0.2 and 1.2 +/- 0.3 nm min-1 mg protein-1 respectively, at 37 degrees C. Antimycin A and rotenone but not 2-thenoyl trifluoroacetone (TTFA) inhibited NCR activity, the EC50 values were 3.6 x 10 (-6) M, 3.7 x 10 (-7) M, respectively. |
1(0,0,0,1) | Details |
| 15627517 | Lee CS, Park SY, Ko HH, Song JH, Shin YK, Han ES: Inhibition of MPP+-induced mitochondrial damage and cell death by trifluoperazine and W-7 in PC12 cells. Neurochem Int. 2005 Jan;46(2):169-78. Trifluoperazine and W-7 (0.5-1 microM) inhibited the nuclear damage, the loss of the mitochondrial transmembrane potential followed by cytochrome c release, and the elevation of intracellular Ca2+ levels due to MPP+ in PC12 cells and attenuated the formation of reactive oxygen species and the depletion of GSH. Calmodulin antagonists (0.5-1 microM) significantly reduced rotenone-induced mitochondrial damage and cell death, whereas they did not attenuate cell death and elevation of intracellular Ca2+ levels due to H2O2 or ionomycin. |
1(0,0,0,1) | Details |
| 808543 | Flatmark T, Romslo I: Energy-dependent accumulation of iron by isolated rat liver mitochondria. J Biol Chem. 1975 Aug 25;250(16):6433-8. The relationship between the rate of endogenous respiration and the energy-dependent accumulation of iron and was studied in rat liver mitochondria energized by external ATP and inhibited to a variable extent by rotenone. Experimental evidence is presented that a primary event of the energy-linked uptake of iron is that Fe (III) is bound to ligands on the C-side of the inner membrane, ligands which have a unique microenvironment giving the metal a half-reduction potential which is sufficiently high to establish a oxidation-reduction equilibrium with the respiratory chain at the level of cytochrome c. |
1(0,0,0,1) | Details |
| 1661844 | Dagani F, Ferrari R, Anderson JJ, Chase TN: does not affect electron transfer chain enzymes and respiration of rat muscle mitochondria. Mov Disord. 1991;6(4):315-9. The maximum activities related to complexes of the respiratory chain: rotenone-sensitive -cytochrome c reductase, -cytochrome c reductase, cytochrome c oxidase, state 3, state 4, uncoupled state, and respiratory control ratio were measured after 17-19 days of treatment. |
81(1,1,1,1) | Details |
| 3037203 | Massie HR, Kogut KA: Influence of age on mitochondrial enzyme levels in Drosophila. Mech Ageing Dev. 1987 Apr;38(2):119-26. The enzymes assayed were rotenone-insensitive -cytochrome c reductase, kinase, cytochrome c reductase, and malate dehydrogenase, located in the outer membrane, inner membrane space, inner membrane and matrix, respectively. |
81(1,1,1,1) | Details |
| 17127363 | Gomez C, Bandez MJ, Navarro A: Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome. Front Biosci. 2007 Jan 1;12:1079-93. The determination of -cytochrome c reductase, -cytochrome c reductase and cytochrome oxidase activities in rat brain submitochondrial showed again the selective inhibition of Complex I by rotenone and pyridaben, whereas paraquat produced a non-selective inhibition affecting all the respiratory chain complexes. |
31(0,1,1,1) | Details |
| 2174585 | Medvedev AE: [Regulation by biogenic amines of energy functions of mitochondria] . Vopr Med Khim. 1990 Sep-Oct;36(5):18-21. Biogenic amines (phenylethylamine, and decreased activities of the rotenone-insensitive -cytochrome c reductase, the cytochrome c reductase and the succinate dehydrogenase in incubation mixtures containing mitochondrial membranes and the monoamine oxidase inhibitors chlorgyline and deprenyl. |
31(0,1,1,1) | Details |
| 1759390 | Medvedev AE, Gorkin VZ: [The role of monoamine oxidase in the regulation of mitochondrial energy functions]. Vopr Med Khim. 1991 Sep-Oct;37(5):2-6. Incubation of aldehyde dehydrogenase-free mitochondrial preparations with biogenic amines and resulted in inhibition of enzymes activity of both outer (rotenone-insensitive -cytochrome c reductase) and inner (succinate dehydrogenase, cytochrome c reductase) mitochondrial membranes. |
31(0,1,1,1) | Details |
| 2528539 | Levrat C, Louisot P, Morelis R: Topological investigations. J Biochem. 1989 Jul;106(1):133-8. The trypsin action on mitochondrial membrane was checked by measuring the activities of marker enzymes (rotenone-insensitive cytochrome c reductase, kinase, and monoamine oxidase). |
31(0,1,1,1) | Details |
| 7632092 | Campos Y, Arenas J, Cabello A, Gomez-Reino JJ: Respiratory chain enzyme defects in patients with idiopathic inflammatory myopathy. Ann Rheum Dis. 1995 Jun;54(6):491-3. Activity of rotenone sensitive cytochrome c reductase (complex I and III) succinate dehydrogenase (complex II), cytochrome c reductase (complex II and III), cytochrome c oxidase (complex IV), and citrate synthase (a mitochondrial matrix enzyme), was measured spectrophotometrically in muscle homogenates. |
31(0,1,1,1) | Details |
| 7306601 | Lemeshko VV: [Effect of on the cytochrome c reductase activity of microsomes and outer mitochondrial membrane of rat liver depending on age]. Biokhimiia. 1981 Oct;46(10):1807-14. The rotenone-insensitive -cytochrome c reductase activity and cytochrome b5 content in mitochondria and microsomes of liver of 1-, 3-, 12- and 24-month-old rats were studied. |
7(0,0,1,2) | Details |
| 3100753 | Kobayashi M, Morishita H, Sugiyama N, Yokochi K, Nakano M, Wada Y, Hotta Y, Terauchi A, Nonaka I: Two cases of NADH-coenzyme Q reductase deficiency: relationship to MELAS syndrome. J Pediatr. 1987 Feb;110(2):223-7. Rotenone-sensitive cytochrome c reductase activities were decreased to 8% (patient 1) and 6% (patient 2) of control values; cytochrome c reductase and cytochrome c oxidase values were within normal limits. |
6(0,0,1,1) | Details |
| 2144730 | Tonsgard JH, Tung B, Kornafel KS, Getz GS: Environmentally induced differential amplification of mitochondrial populations. Biochem J. 1990 Sep 1;270(2):511-8. The TL mitochondrial -cytochrome c reductase is resistant to rotenone, whereas that of A9 mitochondria is sensitive to this agent. |
6(0,0,1,1) | Details |
| 18211809 | Jiang J, Huang Z, Zhao Q, Feng W, Belikova NA, Kagan VE: Interplay between bax, reactive species production, and oxidation during apoptosis. Biochem Biophys Res Commun. 2008 Mar 28;368(1):145-50. Epub 2008 Jan 22. Bax/Bak activation and peroxidation are essential for cytochrome c release during apoptosis, yet, the link between them remains elusive. Rotenone caused robust generation but did not trigger peroxidation in Bax/Bak double knockout MEF cells. |
3(0,0,0,3) | Details |
| 2990809 | Kim Y, Fioravanti CF: Reduction and oxidation of cytochrome C by Hymenolepis diminuta (Cestoda) mitochondria. Comp Biochem Physiol B. 1985;81(2):335-9. Both rotenone-sensitive and -insensitive reduced nucleotide-coupled activities were apparent. |
3(0,0,0,3) | Details |
| 4372992 | Foucher B, Chappell JB, McGivan JD: The effects of acetylcolletotrichin on the mitochondrial respiratory chain. Biochem J. 1974 Mar;138(3):415-23. Thus, together with even in the presence of rotenone, markedly decreased the effectiveness of acetylcolletotrichin in inhibiting oxidation. 6. These effects were paralleled in the observed redox changes of cytochrome c. 7. |
1(0,0,0,1) | Details |
| 2332054 | Brustovetsky NN, Amerkhanov ZG, Popova EYu, Konstantinov AA: Reversible inhibition of electron transfer in the FEBS Lett. 1990 Apr 9;263(1):73-6. Cytochrome c reductase segment of the mitochondrial respiratory chain in hibernating ground squirrels.. |
1(0,0,0,1) | Details |
| 19497415 | Santos DM, Santos MM, Viana RJ, Castro RE, Moreira R, Rodrigues CM: Naphtho [2,3-d] isoxazole-4,9-dione-3-carboxylates: potent, non-cytotoxic, antiapoptotic agents. Chem Biol Interact. 2009 Jul 15;180(2):175-82. Epub 2009 Mar 24. Both 1a and 1b significantly increased cell viability, while reducing nuclear fragmentation, caspase-3, -8 and -9 activation, and cytochrome c release induced by camptothecin. Similar protective effects of derivatives were seen in HuH-7 and PC12 cells incubated with distinct apoptotic stimuli, such as camptothecin, TGF-beta1, or rotenone. |
1(0,0,0,1) | Details |
| 11120600 | Single B, Leist M, Nicotera P: Differential effects of bcl-2 on cell death triggered under ATP-depleting conditions. Exp Cell Res. 2001 Jan 1;262(1):8-16. ATP levels were modulated by using mitochondrial inhibitors, such as rotenone or S-nitrosoglutathione, in medium either lacking or supplemented with to stimulate glycolytic ATP generation. Cytochrome c release, normally preceding STS-induced necrosis, was also inhibited by Bcl-2. |
1(0,0,0,1) | Details |
| 12419464 | Choi DH, Kim DH, Park YG, Chun BG, Choi SH: Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med. 2002 Nov 15;33(10):1321-33. Naphthazarin-induced cytotoxicity was evidenced by the ordered development of lysosomal acridine orange relocation, decrease in mitochondrial potential, cytochrome c release, and caspase-9 activation, and was inhibited by guanabenz, rilmenidine, and AGN 192403. Antimycin A and rotenone induced mitochondrial dysfunction primarily, and their cytotoxicities were inhibited only by AGN 192403. |
1(0,0,0,1) | Details |
| 427130 | Kilberg MS, Christensen HN: Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell. Biochemistry. 1979 Apr 17;18(8):1525-30. The activity differed from that of the mitochondria in that it was not inhibited by rotenone or antimycin A. A variety of electron acceptors have been compared as to rate with the following result: ferricyanide greater than cytochrome c greater than cytochrome b5 greater than greater than dichlorophenolindophenol. |
1(0,0,0,1) | Details |
| 3223930 | Raj RK, Puranam RS, Kurup CK, Ramasarma T: Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite. Biochem J. 1988 Dec 1;256(2):559-64. These worms showed active wriggling movements which were not affected by respiratory poisons such as rotenone and This fraction catalysed - and -dependent reduction of both cytochrome c and dyes. |
1(0,0,0,1) | Details |
| 6786284 | Takeshige K, Takayanagi R, Minakami S: Lipid peroxidation and the reduction of ADP-Fe3+ chelate by -ubiquinone reductase preparation from bovine heart mitochondria. Biochem J. 1980 Dec 15;192(3):861-6. The apparent Km values for the coenzymes and the optimal pH of the reactions agreed well with those of the lipid peroxidation of the submitochondrial particles treated with rotenone. |
0(0,0,0,0) | Details |
| 1763894 | Larsson NG, Andersen O, Holme E, Oldfors A, Wahlstrom J: Leber's hereditary optic neuropathy and complex I deficiency in muscle. . Ann Neurol. 1991 Nov;30(5):701-8. There was no decrease in complex I activity measured as ferricyanide reductase or rotenone-sensitive cytochrome c reductase activities. |
0(0,0,0,0) | Details |
| 5500305 | Jones MS, Jones OT: Ferrochelatase of Rhodopseudomonas spheroides. Biochem J. 1970 Sep;119(3):453-62. Fe (2+) is not incorporated aerobically into porphyrins unless an electron donor, or is supplied; the low aerobic rate of metalloporphyrin synthesis obtained is insensitive to rotenone and antimycin. |
0(0,0,0,0) | Details |
| 7810686 | Mohazzab KM, Wolin MS: Properties of a -generating microsomal oxidoreductase, a potential pulmonary artery PO2 sensor. Am J Physiol. 1994 Dec;267(6 Pt 1):L823-31. Microsomes catalyzed an -mediated reduction of several electron acceptor dyes, cytochrome c (rotenone insensitive) and methemoglobin. |
81(1,1,1,1) | Details |
| 47760 | Olivera AA, Meigs RA: Mitochondria from human term placenta. Biochim Biophys Acta. 1975 Mar 20;376(3):436-45. A rotenone- and antimycin-insensitive, exterior pathway for oxidation was demonstrated which could be artificially linked by exogenous cytochrome c to the cytochrome oxidase region of the classical electron transport system. |
81(1,1,1,1) | Details |
| 16174799 | Chen Q, Hoppel CL, Lesnefsky EJ: Blockade of electron transport before cardiac ischemia with the reversible inhibitor amobarbital protects rat heart mitochondria. J Pharmacol Exp Ther. 2006 Jan;316(1):200-7. Epub 2005 Sep 20. Irreversible blockade of electron transport at complex I by rotenone decreases ischemic damage to cardiac mitochondria by decreasing the loss of cytochrome c and preserving respiration through cytochrome oxidase. |
31(0,1,1,1) | Details |
| 7595568 | Erecinnska M, Nelson D, Vanderkooi JM: Effects of NO-generating compounds on synaptosomal energy metabolism. . J Neurochem. 1995 Dec;65(6):2699-705. S-Nitrosocysteine, at 10 microM, inhibited by 80% respiration with and (plus rotenone) in intact synaptosomes and with /cytochrome c in broken preparations. |
31(0,1,1,1) | Details |
| 3412635 | Lucas-Heron B, Loirat MJ, Ollivier B: Severe mitochondrial anomaly in dystrophic mouse skeletal muscle. . Neurosci Lett. 1988 Jul 19;90(1-2):147-51. Mitochondrial fractions were isolated from skeletal muscle of control (C57 BL 6J dy/+) and dystrophic (C57 BL 6J dy/dy) mice, and enzymatic activities (cytochrome c oxidase, rotenone-insensitive cytochrome c reductase) were determined. |
6(0,0,1,1) | Details |
| 7810685 | Mohazzab KM, Wolin MS: Sites of production detected by lucigenin in calf pulmonary artery smooth muscle. Am J Physiol. 1994 Dec;267(6 Pt 1):L815-22. These observations were confirmed by examination of chemiluminescence produced by subcellular fractions, where the major activity detected was an oxidoreductase, which fractionated in a manner closely matching the activity of the microsomal marker enzyme rotenone-insensitive -cytochrome c reductase. |
6(0,0,1,1) | Details |
| 2833420 | Mitsunaga K, Fujino Y, Yasumasu I: Distributions of H+,K+-ATPase and Cl-,HCO3 (-)-ATPase in micromere-derived cells of sea urchin embryos. Differentiation. 1987;35(3):190-6. Considerable activity of rotenone-insensitive -cytochrome c reductase, a marker enzyme for microsome, was detectable in the microsome fraction. |
6(0,0,1,1) | Details |
| 3110216 | Hoppel CL, Kerr DS, Dahms B, Roessmann U: Deficiency of the dehydrogenase component of complex I of mitochondrial electron transport. J Clin Invest. 1987 Jul;80(1):71-7. Mitochondrial NADH dehydrogenase activity (complex I, assayed as rotenone-sensitive oxidase, -duroquinone reductase, and -cytochrome c reductase) was 0-10% of controls, and -ferricyanide reductase activity was 25-50% of controls in the mitochondria and in skin fibroblasts. |
6(0,0,1,1) | Details |
| 6513990 | Takamiya S, Furushima R, Oya H: Electron transfer complexes of Ascaris suum muscle mitochondria: I. Mol Biochem Parasitol. 1984 Oct;13(2):121-34. Characterization of -cytochrome c reductase (complex I-III), with special reference to cytochrome localization.. The enzyme preparation catalyzed the reduction of 1.68 mumol cytochrome c min-1 mg-1 protein at 25 degrees C with but not with and retained its sensitivity to rotenone, piericidin A and 2-heptyl-4-hydroxyquinoline-N-oxide as with the submitochondrial particles. |
3(0,0,0,3) | Details |
| 6245185 | Scholte HR, Busch HF: Early changes of muscle mitochondria in Duchenne dystrophy. J Neurol Sci. 1980 Mar;45(2-3):217-34. Muscles from boys and adults without neuromuscular disease were treated likewise. (2) In adults, muscle possesses a significantly higher specific activity (on protein basis) of monoamine oxidase and rotenone-insenitive -cytochrome c reductase (RINCR) than in boys. With adolescence it increases from 20 +/- 2 (SEM) to 35 +/- 6 mumoles cytochrome c reduced per min per g protein, and it remains at this level. |
1(0,0,0,1) | Details |
| 612129 | Kassabova T, Russanov E: Effect of chronic loading on the functions of rat liver mitochondria. Acta Physiol Pharmacol Bulg. 1977;3(3):42-8. H-DCPIP-reductase, -cytochrome c (DCPIP)-reductase and succinate dehydrogenase) depending on the duration of sulphate treatment and hepatic level. |
1(0,0,0,1) | Details |
| 15764812 | Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J, Xiao D, Zeng Y, Watkins SC, Johnson CS, Trump DL, Lee YJ, Xiao H, Herman-Antosiewicz A: -induced cell death in human prostate cancer cells is initiated by reactive species. J Biol Chem. 2005 May 20;280(20):19911-24. Epub 2005 Mar 11. Exposure of PC-3 cells to growth-suppressive concentrations of SFN resulted in ROS generation, which was accompanied by disruption of mitochondrial membrane potential, cytosolic release of cytochrome c, and apoptosis. The SFN-induced ROS generation was significantly attenuated on pretreatment with mitochondrial respiratory chain complex I inhibitors, including diphenyleneiodonium and rotenone. |
1(0,0,0,1) | Details |
| 187902 | Sokolov GV, Eremina SS, Lozinov AB: [Electron transport chain of the Candida mycoderma mutant lacking cytochromes b and a+a3]. Mikrobiologiia. 1976 May-Jun;45:394-9. The chain lacks cytochromes but contains nucleotides and flavoproteins; it is inhibited by rotenone and benzhydroxamic acid. The "peroxidase" chain consists of nucleotides, cytochrome c, and cytochrome c peroxidase; it is inhibited by |
1(0,0,0,1) | Details |
| 3941077 | Nisimoto Y, Wilson E, Heyl BL, Lambeth JD: NADH dehydrogenase from bovine neutrophil membranes. J Biol Chem. 1986 Jan 5;261(1):285-90. No effects were seen with mitochondrial respiratory inhibitors such as azide, or rotenone, but p-chloromercuribenzoate was strongly inhibitory and N-ethylmaleimide was weakly inhibitory. The enzyme showed greatest electron acceptor activity with ferricyanide (100%), followed by cytochrome c (3.5%), dichloroindophenol (2.7%), and cytochrome b5 (0.34%). |
1(0,0,0,1) | Details |
| 6299966 | Danley DL, Hilger AE, Winkel CA: Generation of peroxide by Candida albicans and influence on murine polymorphonuclear leukocyte activity. Infect Immun. 1983 Apr;40(1):97-102. Both produced 14CO2 when incubated with [1-14C] both reduced cytochrome c, and both fixed radiolabeled iodide, although the fungi required exogenous lactoperoxidase. Iodination by fungi with lactoperoxidase was reduced when blastoconidia were incubated at 25 degrees C or in the presence of catalase and the metabolic inhibitors rotenone, antimycin A, and 2-deoxyglucose. |
1(0,0,0,1) | Details |
| 6255713 | Ludwig P, Schewe T, Ziem K, Rapoport S: [Electron transport particles from bovine heart as a test system in toxicological studies]. Acta Biol Med Ger. 1980;39(4):503-7. 14 standard respiratory inhibitors and substances of toxicological interest were tested on the oxidase and the -cytochrome c oxidoreductase systems of beef heart electron transfer particles (ETP) in the presence and absence of human serum albumin (HSA). It had little effect on the inhibition by rotenone or carboxin, whereas the inhibition by free fatty acids and monoglyceride was greatly decreased. |
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| 15996779 | Sanchez-Reus MI, Peinado II, Molina-Jimenez MF, Benedi J: Fraxetin prevents rotenone-induced apoptosis by induction of endogenous in human neuroblastoma cells. Neurosci Res. 2005 Sep;53(1):48-56. |
0(0,0,0,0) | Details |
| 422535 | Matuda S: Biochemical studies on the muscle microsomes of Ascaris lumbricoides var. suum. J Biochem. 1979 Feb;85(2):343-50. This microsomal b-type cytochrome was reduced by which was inhibited by rotenone and HgCl2. |
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| 10426140 | Cock HR, Cooper JM, Schapira AH: Functional consequences of the 3460-bp mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. J Neurol Sci. 1999 May 1;165(1):10-7. A 60% rotenone-induced decrease in complex I activity was shown to reduce ATP synthesis in normal fibroblasts, indicating that this level of complex I activity was below the threshold required to affect ATP synthesis. |
0(0,0,0,0) | Details |
| 6321463 | Grover AK, Kwan CY, Luchowski E, Daniel EE, Triggle DJ: Subcellular distribution of [3H] nitrendipine binding in smooth muscle. . J Biol Chem. 1984 Feb 25;259(4):2223-6. There was an excellent correlation between the distribution of [3H] nitrendipine binding determined at the nitrendipine concentrations of 0.138 and 1.38 nM, and the distribution of the plasma membrane markers K+-activated ouabain-sensitive p-nitrophenylphosphatase, 5'-nucleotidase, phosphodiesterase I, and Mg-ATPase, but not between the mitochondrial markers cytochrome c, oxidase, -dependent cytochrome c reductase, or rotenone-insensitive -dependent cytochrome c reductase or the putative endoplasmic reticulum marker -dependent cytochrome c reductase. |
0(0,0,0,0) | Details |
| 169530 | Houstek J, Drahota Z: Activity of the inner and outer membrane oxidative enzymes in brown adipose tissue mitochondria. Physiol Bohemoslov. 1975;24(4):297-304. When compared with liver the specific activity of rotenone-insensitive -cytochrome c reductase was found to be seven times lower, the specific activity of monoamineoxidase up to 30 times lower according to the substrate used. 3. |
69(0,2,3,4) | Details |
| 17292807 | Kim YJ, Ko HH, Han ES, Lee CS: inhibition of rotenone- or 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death. Brain Res Bull. 2007 Mar 30;71(6):633-40. Epub 2007 Jan 8. Both rotenone and MPP+ induced the nuclear damage, the changes in the mitochondrial membrane permeability, leading to the cytochrome c release and caspase-3 activation, the formation of reactive species and the depletion of GSH in differentiated PC12 cells. |
62(0,2,2,2) | Details |
| 6507637 | Kennett FF, Knauer TE, Owens K, Weglicki WB: Inhibition of myocardial rotenone-insensitive cytochrome c reductase by amphiphilic compounds. Am J Physiol. 1984 Dec;247(6 Pt 2):H889-94. |
62(0,2,2,2) | Details |
| 2170057 | Yamamoto M, Akiyama C, Aikawa H: D-penicillamine-induced copper deficiency in suckling mice: neurological abnormalities and brain mitochondrial enzyme activities. Brain Res Dev Brain Res. 1990 Aug 1;55(1):51-5. Cytochrome c oxidase activity (complex IV) in the brain showed 51% decrease of the controls, on the contrary, rotenone-sensitive cytochrome c reductase (complex I + III) and cytochrome c reductase (complex II + III) were normal. |
31(0,1,1,1) | Details |
| 6229605 | Vitorica J, Machado A, Satrustegui J: Age-dependent variations in peroxide-utilizing enzymes from rat brain mitochondria and cytoplasm. J Neurochem. 1984 Feb;42(2):351-6. On the other hand, catalase distribution parallels that of -cytochrome c reductase (rotenone-insensitive), and appears to be associated with the outer membrane of brain mitochondria. |
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| 6269601 | Schewe T, Albracht SP, Ludwig P: On the site of action of the inhibition of the mitochondrial respiratory chain by lipoxygenase. Biochim Biophys Acta. 1981 Jul;636(2):210-7. The Fe-S clusters of the mitochondrial outer membrane are destroyed by lipoxygenase treatment, without any effect on the rotenone-insensitive cytochrome c oxidoreductase activity. |
6(0,0,1,1) | Details |
| 6742854 | Yoshida S, Yubisui T, Takeshita M: Characteristics of b-type cytochromes in brain microsomes: comparison with liver microsomes. Arch Biochem Biophys. 1984 Jul;232(1):296-304. First, the kinetic constants, Km and Vmax, in rotenone-insensitive -cytochrome c reductase activity were different from those of liver microsomes, and the activity of cerebral microsomes was higher than that of liver microsomes. |
6(0,0,1,1) | Details |
| 2493147 | Ichiki T, Tanaka M, Kobayashi M, Sugiyama N, Suzuki H, Nishikimi M, Ohnishi T, Nonaka I, Wada Y, Ozawa T: Disproportionate deficiency of iron- clusters and subunits of complex I in mitochondrial encephalomyopathy. Pediatr Res. 1989 Feb;25(2):194-201. Rotenone-sensitive -cytochrome c reductase activity was found to be decreased in all the tissues examined. |
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| 11097871 | Gennari A, Viviani B, Galli CL, Marinovich M, Pieters R, Corsini E: Organotins induce apoptosis by disturbance of [Ca (2+)](i) and mitochondrial activity, causing oxidative stress and activation of caspases in rat thymocytes. Toxicol Appl Pharmacol. 2000 Dec 1;169(2):185-90. Simultaneously, organotins induced the release of cytochrome c from the mitochondrial membrane into the cytosol. ROS production and the release of cytochrome c were reduced by BAPTA, an intracellular Ca (2+) chelator, or rotenone, an inhibitor of the electron entry from complex I to indicating the important role of Ca (2+) and mitochondria during these early intracellular events. |
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| 7622786 | Goyal N, Srivastava VM: Oxidation and reduction of cytochrome c by mitochondrial enzymes of Setaria cervi. J Helminthol. 1995 Mar;69(1):13-7. All the three reductases exhibited marked sensitivity to rotenone and antimycin A. |
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| 19016854 | La Piana G, Gorgoglione V, Laraspata D, Marzulli D, Lofrumento NE: Effect of on the activity of the cytosolic /cytochrome c electron transport system. FEBS J. 2008 Dec;275(24):6168-79. Epub 2008 Nov 5. |
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| 7727510 | Gonzalez-Flecha B, Boveris A: Mitochondrial sites of peroxide production in reperfused rat kidney cortex. Biochim Biophys Acta. 1995 Apr 13;1243(3):361-6. H2O2 production rates were assessed in isolated mitochondria using either with and without antimycin, or - with and without rotenone. Respiratory activities of isolated mitochondria and activity of - and -cytochrome c reductase and of - and succinate-dehydrogenase in submitochondrial particles were measured to evaluate the electron flux throughout respiratory carriers. |
2(0,0,0,2) | Details |
| 11952418 | Shchepina LA, Popova EN, Pletjushkina OY, Chernyak BV: Respiration and mitochondrial membrane potential are not required for apoptosis and anti-apoptotic action of Bcl-2 in HeLa cells. Biochemistry. 2002 Feb;67(2):222-6. The release of cytochrome c from intermembrane space of mitochondria into cytosol is one of the critical events in apoptotic cell death. In the present study it was shown that apoptosis and release of cytochrome c induced by staurosporine or by tumor necrosis factor-alpha in HeLa cells were not affected by inhibitors of respiration (rotenone, myxothiazol, antimycin A) or by uncouplers (CCCP, DNP) that decrease the membrane potential at the inner mitochondrial membrane. |
1(0,0,0,1) | Details |
| 167532 | Bartoli GM, Dani A, Galeotti T, Russo M, Terranova T: Respiratory activity of Ehrlich ascites tumour cell nuclei. . Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975;83(3):223-31. Among the respiratory pigments analysed spectrophotometrically in the microsomal fraction prepared from ascites cells, only small amounts of flavoproteins (NADH-cytochrome b5 reductase and -cytochrome c reductase) were detectable. 3. |
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| 4326588 | Prichard RK, Schofield PJ: Fasciola hepatica: cytochrome c oxidoreductases and effects of tension and inhibitors. Exp Parasitol. 1971 Apr;29(2):215-22. |
1(0,0,0,1) | Details |
| 10463952 | Kiningham KK, Oberley TD, Lin S, Mattingly CA, St Clair DK: Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly (ADP- polymerase-mediated cell death. FASEB J. 1999 Sep;13(12):1601-10. Activation of caspase-3 (CPP-32) occurred in the NEO cells independent of cytochrome c release from the mitochondria. MnSOD overexpression specifically protected against cell death upon treatment with rotenone or antimycin. |
1(0,0,0,1) | Details |
| 215123 | Heron C, Ragan CI, Trumpower BL: The interaction between mitochondrial NADH-ubiquinone oxidoreductase and -cytochrome c oxidoreductase. Biochem J. 1978 Sep 15;174(3):791-800. |
1(0,0,0,1) | Details |
| 15228597 | Gyulkhandanyan AV, Pennefather PS: Shift in the localization of sites of peroxide production in brain mitochondria by mitochondrial stress. J Neurochem. 2004 Jul;90(2):405-21. In addition, three forms of in vitro mitochondrial stress were studied: Ca (2+) overload, cold storage for more than 24 h and cytochrome c depletion. H (2) O (2) production supported by during reverse transfer of electrons was decreased by inhibitors of complex I (rotenone and diphenyleneiodonium) whereas in /-oxidizing mitochondria diphenyleneiodonium decreased while rotenone increased H (2) O (2) generation. |
1(0,0,0,1) | Details |
| 16663322 | Day DA, Neuburger M, Douce R, Wiskich JT: Exogenous NAD Effects on Plant Mitochondria: A Reinvestigation of the Transhydrogenase Hypothesis. Plant Physiol. 1983 Dec;73(4):1024-1027. Addition of NAD (+) to purified potato (Solanum tuberosum L.) mitochondria respiring alpha-ketoglutarate and in the presence of the electron transport inhibitor rotenone, stimulated O (2) uptake. NAD (+)-stimulated -cytochrome c reductase activity, and reduction of added NAD (+) by intact mitochondria, could be duplicated by rupturing the mitochondria and adding a small quantity to the cuvette. |
1(0,0,0,1) | Details |
| 11741286 | Armstrong JS, Hornung B, Lecane P, Jones DP, Knox SJ: Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW. Biochem Biophys Res Commun. 2001 Dec 21;289(5):973-8. Biochemical features of apoptosis included mitochondrial cytochrome c release, reactive species generation, and the activation of procaspase 3. |
1(0,0,0,1) | Details |
| 6289887 | Bindoli A, Cavallini L, Jocelyn P: Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by Biochim Biophys Acta. 1982 Sep 15;681(3):496-503. Gradient-separated and cytochrome c-depleted mitochondria, mitoplasts and submitochondrial fractions also undergo this peroxidation. Conversely, rotenone and N-ethylmaleimide stimulate the reaction. |
1(0,0,0,1) | Details |
| 9886268 | Sambo P, Jannino L, Candela M, Salvi A, Donini M, Dusi S, Luchetti MM, Gabrielli A: Monocytes of patients wiht systemic sclerosis (scleroderma spontaneously release in vitro increased amounts of J Invest Dermatol. 1999 Jan;112(1):78-84. Employing the superoxide dismutase-inhibitable reduction of cytochrome c to evaluate the generation of O2*-, unmanipulated monocytes of SSc patients generated more O2*- than primary Raynaud's phenomenon patients and normal control monocytes (p = 0.0001), and the release was higher in patients with diffuse cutaneous involvement and 5 y or less disease duration (p = 0.02). The involvement of mitochondrial oxidases was excluded by the lack of inhibition of O2*- production when monocytes were incubated in the presence of rotenone, a mitochondrial oxidase inhibitor. |
1(0,0,0,1) | Details |
| 16207793 | Potokar M, Kreft M, Chowdhury HH, Vardjan N, Zorec R: Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. Am J Physiol Cell Physiol. 2006 Mar;290(3):C672-7. Epub 2005 Oct 5. We show herein that 2 h after triggering apoptosis with rotenone, Apaf-1 redistributed to the proximity of mitochondria. Furthermore, we show herein for the first time in single cells that the colocalization between Apaf-1 and cytochrome c increases only transiently, indicating a transient interaction between cytochrome c and Apaf-1 during the activation of apoptosis in these cells. |
1(0,0,0,1) | Details |
| 4356125 | Barnes R, Colleran EM, Jones OT: The electron-transport system of mitochondria from the slime mould Physarum polycephalum. Biochem J. 1973 Jul;134(3):745-51. P. polycephalum mitochondria oxidized added via a rotenone-insensitive pathway, but the oxidation of plus was rotenone sensitive; both of these substrates reduced much less cytochrome b than did in both aerobic and anaerobic steady states. Spectroscopy at 77 degrees K separated three absorption maxima in the alpha-band region, at 560nm, 553nm and one at 547nm due to cytochrome c. |
1(0,0,0,1) | Details |
| 16990510 | Chen Q, Moghaddas S, Hoppel CL, Lesnefsky EJ: Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion. J Pharmacol Exp Ther. 2006 Dec;319(3):1405-12. Epub 2006 Sep 21. The reversible blockade of electron transport during ischemia with amobarbital, an inhibitor at the rotenone site of complex I, protects mitochondria against ischemic damage. |
0(0,0,0,0) | Details |
| 8417013 | Zaidan E, Sims NR: Selective reductions in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain subregions following forebrain ischemia in rats. J Cereb Blood Flow Metab. 1993 Jan;13(1):98-104. No significant changes were observed in the activity of two other mitochondrial markers, rotenone-sensitive -cytochrome c oxidoreductase and alpha-ketoglutarate dehydrogenase. |
0(0,0,0,0) | Details |
| 216232 | Kassabova T, Russanov E: Decorporation of from liver subcellular fractions after alimentary loading of rats. Acta Physiol Pharmacol Bulg. 1978;4(2):13-9. The activities of rotenone-sensitive -cytochrome c reductase, -cytochrome c reductase and cytochrome oxidase were inhibited by treatment but after a 4-day decorporation they became normal. |
62(0,2,2,2) | Details |
| 6530010 | Szczesna-Kaczmarek A, Litwinska D, Popinigis J: Oxidation of via an "external" pathway in skeletal-muscle mitochondria and its possible role in the repayment of lactacid debt. Int J Biochem. 1984;16(12):1231-5. Mitochondria isolated from skeletal muscle of rat catalyse oxidation of the external (in the presence of rotenone, antimycin A and cytochrome c) at a rate of 15 natoms O2/min/mg protein by a pathway sensitive to mersalyl. |
62(0,2,2,2) | Details |
| 4262959 | Margreth A, Salviati G, Di Mauro S, Turati G: Early biochemical consequences of denervation in fast and slow skeletal muscles and their relationship to neural control over muscle differentiation. Biochem J. 1972 Mar;126(5):1099-110. The isolated sarcoplasmic reticulum from fast muscle showed a slight diminution of ATPase-linked Ca (2+)-transport activity and a selective increase of rotenone-insensitive -cytochrome c reductase activity, in addition to a greater emphasis on slow-type electrophoretic components of the structural membrane protein. 7. |
31(0,1,1,1) | Details |
| 232293 | Gurtubay JI, Martinez J, Gutierrez-Arranz A, Goni FM: Assay of mitochondrial membrane-bound enzyme activities in the presence of triton X-100. Rev Esp Fisiol. 1979 Dec;35(4):395-400. cytochrome c reductase and rotenone-sensitive cytochrome c reductase activities are destroyed even a low detergent concentrations. |
6(0,0,1,1) | Details |
| 226438 | Bouhnik J, Clot JP, Baudry M, Michel R: Early effects of thyroidectomy and administration on rat-liver mitochondria. Mol Cell Endocrinol. 1979 Jul;15(1):1-12. The decrease in the activity of the inner-membrane enzymes closely followed the disappearance of T3 and T4 from serum. 10 h after administration of 25 micrograms/100 g T3 to thyroidectomized rats, the activity of and cytochrome c reductases and the consumption rate with or were significantly increased, while, in the outer membrane, the activity of monoamine oxidase and rotenone-insensitive -cytochrome c reductase remained unchanged. |
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| 8986635 | Pitkanen S, Raha S, Robinson BH: Diagnosis of complex I deficiency in patients with lactic acidemia using skin fibroblast cultures. Biochem Mol Med. 1996 Dec;59(2):134-7. Values for -cytochrome c reductase (rotenone sensitive) were compared for a series of three controls and nine patients with complex I (NADH-coenzyme Q reductase deficiency). |
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| 224923 | Bers DM: Isolation and characterization of cardiac sarcolemma. Biochim Biophys Acta. 1979 Jul 19;555(1):131-46. There may, however, be some contamination by outer mitochondrial membranes (as judged by monoamine oxidase and rotenone-insensitive cytochrome c reductase activities) which have rarely been monitored in cardiac sarcolemmal preparations. |
6(0,0,1,1) | Details |
| 6249259 | Cadenas E, Boveris A, Chance B: Low-level chemiluminescence of bovine heart submitochondrial particles. Biochem J. 1980 Mar 15;186(3):659-67. Antimycin and rotenone increased chemiluminescence by 50-60%; addition of substrates, and did not produce marked changes in the observed chemiluminescence. Externally added cytochrome c (10-20mum) had a marked stimulatory effect on chemiluminescence, namely a 12-fold increase in light-emission of antimycin-inhibited submitochondrial particles. |
2(0,0,0,2) | Details |
| 183977 | Scislowski P, Swierczynski J: Some properties of external oxidation by human placental mitochondria. Experientia. 1976 Sep 15;32(9):1118-20. Isolated human term placenta mitochondria catalyse oxidation of external in the presence of cytochrome c. This reaction is insensitive to the respiratory chain inhibitors such as rotenone and antimycin A, and is not coupled to phosphorylation. |
2(0,0,0,2) | Details |
| 933879 | Shavlovskii GM, Fedorovich DV, Zviagil'skais RA: [A flavinogenic mutant of the yeast Pichia guilliermondii with impaired iron transport]. Mikrobiologiia. 1976 Mar-Apr;45(2):313-8. The content of total and non-hemin iron and cytochrome c, and the activity of catalase, were lower in the cells of the mutant than in the parent cells, while the activity of synthetase was higher. Rotenone inhibited respiration of the intact cells of the mutant producing elevated amounts of therefore, flavinogenesis was not regulated by non-hemin iron on the first segment of the respiratory chain. |
1(0,0,0,1) | Details |
| 8240360 | Crowe RA, Taparowsky EJ, Crane FL: Ha-ras stimulates the transplasma membrane oxidoreductase activity of C3H10T1/2 cells. Biochem Biophys Res Commun. 1993 Oct 29;196(2):844-50. Both cytochrome c and ferricyanide are reduced at a faster rate by C3H10T1/2 cells which are expressing the Ha-ras oncogene. |
1(0,0,0,1) | Details |
| 7150580 | Hatefi Y, Yagi T: Kinetics of cytochrome b oxidation in antimycin-treated submitochondrial particles. Biochemistry. 1982 Dec 7;21(25):6614-8. By contrast, rotenone, BAL (2,3-dimercaptopropanol), and 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole [Trumpower, B. Having thus ascertained that the electron leak through the antimycin block appeared to follow the normal path through complex III cytochrome c oxidoreductase) and cytochrome oxidase, the reduction of the b cytochromes by substrates and their oxidation through the leak in the antimycin block by molecular were studied. |
1(0,0,0,1) | Details |
| 947364 | Harmon HJ, Crane FL: Inhibition of mitochondrial electron transport by hydrophilic metal chelators. Biochim Biophys Acta. 1976 Jul 9;440(1):45-58. Inter-complex electron flow is prevented by rotenone or thenoyltrifluoroacetone. Reductions of juglone, ferricyanide, indophenol, duroquinone, and cytochrome c by are inhibited to different extents on both sides of the membrane by the impermeant hydrophilic chelators bathophenanthroline sulfonate and orthophenanthroline. |
1(0,0,0,1) | Details |
| 2871147 | Sugiyama Y, Fujita T, Matsumoto M, Okamoto K, Imada I: Effects of idebenone (CV-2619) and its metabolites on respiratory activity and lipid peroxidation in brain mitochondria from rats and dogs. J Pharmacobiodyn. 1985 Dec;8(12):1006-17. These facts and results of inhibitor analysis suggest that the action site of CV-2619 is -linked complex I in the mitochondrial respiratory chain and is different from that of inhibitors of oxidative phosphorylation such as rotenone, oligomycin and 2,4-dinitrophenol. CV-2619 (10 (-5) M) strongly inhibited both types of the lipid peroxidation reactions and protected the resultant inactivation of the -cytochrome c reductase activity. |
1(0,0,0,1) | Details |
| 8390225 | Berridge MV, Tan AS: Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT): subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction. Arch Biochem Biophys. 1993 Jun;303(2):474-82. -dependent mitochondrial MTT reduction was inhibited by 80% with chlorpromazine, 70% by antimycin A, and 85-90% by thenoyltrifluoracetone (TTFA), but inhibition was not observed with rotenone at < or = 2 microM, Amytal, or azide. These results suggest that when is used as an electron donor, 70-80% of mitochondrial MTT reduction occurs subsequent to transfer of electrons from cytochrome c to cytochrome oxidase, but prior to the point of azide inhibition. |
1(0,0,0,1) | Details |
| 10717001 | Weinberg JM, Venkatachalam MA, Roeser NF, Nissim I: Mitochondrial dysfunction during hypoxia/reoxygenation and its correction by anaerobic metabolism of cycle intermediates. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2826-31. Rotenone, but not antimycin or oligomycin, prevented this effect, indicating that electron transport in complex I, rather than F (1) F (0)-ATPase activity, had been responsible for maintenance of DeltaPsi (m) by the substrates. Thus, tubule cells subjected to hypoxia/reoxygenation can have persistent energy deficits associated with complex I dysfunction for substantial periods of time before onset of the mitochondrial permeability transition and/or loss of cytochrome c. |
1(0,0,0,1) | Details |
| 10987825 | Bal-Price A, Brown GC: -induced necrosis and apoptosis in PC12 cells mediated by mitochondria. J Neurochem. 2000 Oct;75(4):1455-64. A 24-h incubation of PC12 cells with NO donors (SNAP or NOC-18) or specific inhibitors of mitochondrial respiration (myxothiazol, rotenone, or azide), in the absence of caused total ATP depletion and resulted in 80-100% necrosis. |
0(0,0,0,0) | Details |
| 11358527 | Fang J, Wang Y, Beattie DS: Isolation and characterization of complex I, rotenone-sensitive oxidoreductase, from the procyclic forms of Trypanosoma brucei. Eur J Biochem. 2001 May;268(10):3075-82. |
0(0,0,0,0) | Details |
| 4323963 | Wong DT, Horng JS, Gordee RS: Respiratory chain of a pathogenic fungus, Microsporum gypseum: effect of the antifungal agent pyrrolnitrin. J Bacteriol. 1971 Apr;106(1):168-73. In mitochondrial preparations, pyrrolnitrin strongly inhibited respiration and the rotenone-sensitive -cytochrome c reductase. |
62(0,2,2,2) | Details |
| 2256918 | Chretien D, Bourgeron T, Rotig A, Munnich A, Rustin P: The measurement of the rotenone-sensitive cytochrome c reductase activity in mitochondria isolated from minute amount of human skeletal muscle. Biochem Biophys Res Commun. 1990 Nov 30;173(1):26-33. Using such a simple procedure, the cytochrome c reductase was found 70-80% inhibited by rotenone and roughly equivalent to 70-85% of the activity of the cytochrome c reductase. |
49(0,1,4,4) | Details |
| 8158142 | Veuthey AL, Tsacopoulos M, Millan de Ruiz L, Perrottet P: Cellular and subcellular localization of hexokinase, dehydrogenase, and alanine aminotransferase in the honeybee drone retina. J Neurochem. 1994 May;62(5):1939-46. The distribution of enzymatic markers of mitochondria (succinate dehydrogenase, rotenone-insensitive cytochrome c reductase, and kinase) indicated that the outer mitochondrial membrane was partly damaged, but their distributions were different from that of hexokinase. |
31(0,1,1,1) | Details |
| 3168972 | Dechecchi MC, Girella E, Cabrini G, Berton G: The Km of NADH dehydrogenase is decreased in mitochondria of cystic fibrosis cells. Enzyme. 1988;40(1):45-50. The kinetic properties of the NADH dehydrogenase of the mitochondrial respiratory chain, assayed as -dependent rotenone-sensitive cytochrome c reductase have been studied in mitochondria isolated from mononuclear white blood cells in patients affected by cystic fibrosis. |
6(0,0,1,1) | Details |
| 2986257 | Weglicki WB, Kramer JH, Kennett FF, Knauer TE, Owens K: Perturbations of sarcolemmal and microsomal enzymes by amphiphilic lipids and drugs. Adv Myocardiol. 1985;6:127-36. SL Na+, K+-ATPase (2.35 mumole/min per mg) was enriched 117-fold over the homogenate and MC rotenone-insensitive cytochrome c reductase (RINCR) was enriched 41-fold. |
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| 856833 | Jarasch ED, Bruder G, Keenan TW, Franke WW: Redox constituents in milk fat globule membranes and rough endoplasmic reticulum from lactating mammary gland. J Cell Biol. 1977 Apr;73(1):223-41. Both fractions contained significant amounts of a b-type cytochrome with several properties similar to those of cytochrome b5 from liver, as well as a rotenone-insensitive - and -cytochrome c reductase. |
6(0,0,1,1) | Details |
| 8184686 | Wu CM, Lee DH, Hong YC, Wen DW, Chou CF, Chung MT: Changes of respiratory chain enzyme activities in growing rat muscle mitochondria. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1994 Mar-Apr;35(2):113-8. The activities of three mitochondrial respiratory chain enzymes, namely rotenone sensitive -cytochrome c reductase (NCCR), -cytochrome c reductase (SCCR), and cytochrome c oxidase (CCO) in the extensor digitorum longus muscle were determined in Wistar rats, twenty each, at 3, 4, 5, 6, 10 and 26 weeks of age. |
6(0,0,1,1) | Details |
| 22598 | Della Corte L, Callingham BA: The influence of adrenalectomy on monoamine oxidase and cytochrome c reductase in the rat heart. J Pharm Pharmacol. 1977 Nov;29(11):657-63. However, both the total and the rotenone-insensitive NCR activities increased, with that of the rotenone-insensitive being about half of the total, which indicated that the effect of adrenalectomy was exerted on components of this enzyme localized on both the inner and outer membranes of the mitochondrion. |
2(0,0,0,2) | Details |
| 12588799 | Darios F, Corti O, Lucking CB, Hampe C, Muriel MP, Abbas N, Gu WJ, Hirsch EC, Rooney T, Ruberg M, Brice A: Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death. Hum Mol Genet. 2003 Mar 1;12(5):517-26. In this cell line, neuronally differentiated by nerve growth factor, Parkin overproduction protected against cell death mediated by but not by a variety of other cell death inducers (H (2) O (2), rotenone, 6-OHDA, tunicamycin, 2-mercaptoethanol and staurosporine). |
2(0,0,0,2) | Details |
| 12241070 | Mildaziene V, Nauciene Z, Krab K: The targets of 2,2',5,5'-tetrachlorobiphenyl in the respiratory chain of rat liver mitochondria revealed by modular kinetic analysis. Mol Biol Rep. 2002;29(1-2):31-4. The effects of 20 microM 2,2',5,5'-TCB on the activity of the respiratory chain modules in rat liver mitochondria oxidizing (+ rotenone) in state 3 were assessed. Analysis around cytochrome c revealed that 2,2',5,5'-TCB inhibited both cytochrome c-oxidizing and reducing modules. |
1(0,0,0,1) | Details |
| 4359654 | Drabikowska A, Kosmakos FC, Brodie AF: Studies of respiratory components and oxidative phosphorylation in mitochondria of mi-1 Neurospora crassa. J Bacteriol. 1974 Feb;117(2):733-40. Difference spectra of mitochondria from young cultures of the mi-1 mutant revealed the presence of cytochrome c. |
1(0,0,0,1) | Details |
| 15535970 | Haslett MR, Pink D, Walters B, Brosnan ME: Assay and subcellular localization of dehydrogenase in rat liver. Biochim Biophys Acta. 2004 Nov 18;1675(1-3):81-6. A spectrophotometric assay for P5CDh was shown to be valid if rotenone was included in the assay to prevent reoxidation of P5CDh is enriched only in the mitochondrial fractions, as are the mitochondrial enzymes, cytochrome c reductase, oxidase, glutaminase, and ornithine aminotransferase. |
1(0,0,0,1) | Details |
| 17102131 | Brown NM, Martin SM, Maurice N, Kuwana T, Knudson CM: Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells. J Biol Chem. 2007 Jan 26;282(4):2144-55. Epub 2006 Nov 13. Following interleukin (IL)-3 withdrawal in FL5.12 cells, Bax undergoes a conformational change that results in its mitochondria targeting, cytochrome c release, activation of caspase-9, and apoptosis. Furthermore, the "rescued" cells were resistant to rotenone, an inhibitor of mitochondrial respiration. |
1(0,0,0,1) | Details |
| 12952965 | Grether-Beck S, Felsner I, Brenden H, Krutmann J: Mitochondrial cytochrome c release mediates -induced activator protein 2 activation and gene expression in keratinocytes. J Biol Chem. 2003 Nov 28;278(48):47498-507. Epub 2003 Sep 2. Inhibitors of mitochondrial electron transport chain (e.g. rotenone, thenoyltrifluoroacetone, and antimycin A) reduced -induced ICAM-1 expression. |
1(0,0,0,1) | Details |
| 18619991 | Chen KC, Lin SR, Chang LS: Involvement of mitochondrial alteration and reactive species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon. 2008 Aug 1;52(2):361-8. Epub 2008 Jun 24. The apoptosis signals of CTX3 included reactive species (ROS) generation, disruption of mitochondrial membrane potential (DeltaPsim), cytochrome c release to the cytosol and activation of caspase-9 and -3. Co-incubation with rotenone, an inhibitor of mitochondrial electron transport chain complexes I, resulted in partial inhibition of CTX3-induced ROS generation but not the loss of DeltaPsim. |
1(0,0,0,1) | Details |
| 10063813 | Molano F, Saborido A, Delgado J, Moran M, Megias A: Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Med Sci Sports Exerc. 1999 Feb;31(2):243-50. The mitochondrial respiratory chain activities rotenone-sensitive -cytochrome c reductase (NCCR), cytochrome c reductase (SCCR), and cytochrome oxidase (COX) showed a significant decrease in steroid-administered rats, whereas citrate synthase (CS), a matrix enzyme, exhibited no changes in activity, pointing to a selective effect of AAS on mitochondrial membrane complexes. |
0(0,0,0,0) | Details |
| 8882715 | Takahashi T, Okamoto T, Kishi T: Characterization of -dependent ubiquinone reductase activity in rat liver cytosol: effect of various factors on -reducing activity and discrimination from other quinone reductases. J Biochem. 1996 Feb;119(2):256-63. Rotenone, antimycin A, and KCN, which inhibit mitochondrial and microsomal electron transfer enzymes, superoxide dismutase, and acetylated cytochrome c had no effect on the -UQ reductase activity. |
0(0,0,0,0) | Details |
| 169529 | Zeit-Har SA, Drahota Z: The development of mitochondrial oxidative enzymes in rat heart muscle. . Physiol Bohemoslov. 1975;24(4):289-96. Three different developmental patterns have been found in the heart muscle mitochondria: (a) Activity of inner membrane enzymes, -cytochrome c reductase and rotenone-sensitive -cytochrome c reductase, was found to increase rapidly after birth till the 25th day; no further increase was found till the 60th day. |
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| 17435593 | Lim ML, Mercer LD, Nagley P, Beart PM: Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic neurons. Neuroreport. 2007 Mar 5;18(4):307-12. Rotenone and 1-methyl-4-phenylpyridinium produce parkinsonian models and we determined whether their mitochondrially mediated actions differentially redistributed the apoptogenic proteins, apoptosis-inducing factor and cytochrome c. |
44(0,1,3,4) | Details |
| 15686486 | Clayton R, Clark JB, Sharpe M: Cytochrome c release from rat brain mitochondria is proportional to the mitochondrial functional deficit: implications for apoptosis and neurodegenerative disease. J Neurochem. 2005 Feb;92(4):840-9. Titration of rat brain mitochondrial respiratory function, with the specific complex I inhibitor rotenone, caused proportional release of cytochrome c from isolated synaptic and non-synaptic mitochondria. |
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| 1753716 | Lamperth L, Dalakas MC, Dagani F, Anderson J, Ferrari R: Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model. Lab Invest. 1991 Dec;65(6):742-51. Study of the mitochondrial functions assessed by evaluating stimulated consumption rate, enzymatic activities of electron transport chain and coupling state of oxidative phosphorylation (respiratory control ratio) revealed a decrease in rotenone-sensitive cytochrome C reductase (complex I + III) and an uncoupling effect demonstrated by decreased respiratory control ratio. |
31(0,1,1,1) | Details |
| 15806174 | Lee YJ, Lee DH, Cho CK, Chung HY, Bae S, Jhon GJ, Soh JW, Jeoung DI, Lee SJ, Lee YS: HSP25 inhibits radiation-induced apoptosis through reduction of PKCdelta-mediated ROS production. Oncogene. 2005 May 26;24(23):3715-25. In the present study, radiation-induced cytochrome c release from mitochondria and activation of caspases accompanied by a decrease of mitochondrial membrane potential in Jurkat T cells were shown to be inhibited by mitochondrial complex I inhibitor rotenone, suggesting that mitochondrial ROS might be important in radiation-induced caspase-dependent apoptosis. |
31(0,1,1,1) | Details |
| 4009171 | Gonatas JO, Gonatas NK, Stieber A, Fleischer B: Isolation and characterization of an enriched Golgi fraction from neurons of developing rat brains. J Neurochem. 1985 Aug;45(2):497-507. The activities of the possible marker enzymes rotenone-insensitive -cytochrome c reductase, -cytochrome c reductase, and arylsulfatase were low or minimally elevated in the Golgi fractions. |
6(0,0,1,1) | Details |
| 3032255 | Sikpi MO, Das SK: The localization of cholinephosphotransferase in the outer membrane of guinea-pig lung mitochondria. Biochim Biophys Acta. 1987 May 12;899(1):35-43. Similar subcellular distribution patterns were observed for both cholinephosphotransferase and rotenone-insensitive -cytochrome c reductase, an enzyme associated with the outer membrane of mitochondria and endoplasmic reticulum, suggesting that cholinephosphotransferase may be localized in both of these organelles. |
6(0,0,1,1) | Details |
| 16337891 | Li Q, Sato EF, Kira Y, Nishikawa M, Utsumi K, Inoue M: A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis. Free Radic Biol Med. 2006 Jan 1;40(1):173-81. Epub 2005 Oct 21. Although inhibitors of electron transport, such as rotenone, antimycin A, and KCN, also increased ROS generation, they failed to (i) oxidize the critical thiol groups in ANT, (ii) induce swelling, and (iii) release SOD1 and cytochrome c. |
6(0,0,0,6) | Details |
| 192732 | Wiseman A, Gillham NW, Boynton JE: Nuclear mutations affecting mitochondrial structure and function in Chlamydomonas. J Cell Biol. 1977 Apr;73(1):56-77. Mutants in Class I have gross alterations in the ultrastructure of their mitochondrial inner membranes together with deficiencies in cytochrome oxidase and antimycin/rotenone-sensitive -cytochrome c reductase activities. |
6(0,0,1,1) | Details |
| 5379109 | Wilson RH, Hanson JB: The effect of respiratory inhibitors on and oxidation in corn mitochondria. Plant Physiol. 1969 Sep;44(9):1335-41. The inhibitors, rotenone, amytal, antimycin A and inhibited oxidation of in state 3 but rotenone and amytal did not inhibit oxidation in state 4. The inhibition by antimycin A was partially overcome by the presence of cytochrome c. |
2(0,0,0,2) | Details |
| 6243963 | Malviya AN, Nicholls P, Elliott WB: Observations on the oxidoreduction of the two cytochromes b in cytochrome c-deficient mitochondria and submitochondrial particles. Biochim Biophys Acta. 1980 Jan 4;589(1):137-49. Cytochrome bT reduced in the presence of antimycin can be reoxidized by O2 if rotenone is added to an -reduced sysem or to a -reduced system. |
2(0,0,0,2) | Details |
| 19631247 | Liang JH, Du J, Xu LD, Jiang T, Hao S, Bi J, Jiang B: Catalpol protects primary cultured cortical neurons induced by Abeta (1-42) through a mitochondrial-dependent caspase pathway. Neurochem Int. 2009 Dec;55(8):741-6. Epub 2009 Jul 22. It has been reported that catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa, protected cells from damage induced by a variety of toxic stimulus such as LPS, MPP (+) and rotenone. By exposure to Abeta (1-42) (5 microM) for 72 h in cultures, neuronal apoptosis occurred characterized by enhancement of activities of caspases and reactive species (ROS) as well as Bax increase, loss of mitochondrial membrane potential and cytochrome c release. |
1(0,0,0,1) | Details |
| 12538580 | De Sarno P, Shestopal SA, King TD, Zmijewska A, Song L, Jope RS: Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition. J Biol Chem. 2003 Mar 28;278(13):11086-93. Epub 2003 Jan 21. Muscarinic receptor stimulation also protected cells from caspase-3 activation induced by exposure to rotenone, a mitochondrial complex 1 inhibitor, but no protection was evident from staurosporine-induced caspase-3 activation. The mechanism of protection afforded by muscarinic receptor activation from camptothecin-induced apoptotic signaling involved blockade of mitochondrial cytochrome c release associated with a bolstering of mitochondrial bcl-2 levels and blockade of the translocation of Bax to mitochondria. |
1(0,0,0,1) | Details |
| 8631334 | Volkel S, Grieshaber MK: Mitochondrial sulfide oxidation in Arenicola marina. Eur J Biochem. 1996 Jan 15;235(1-2):231-7. We suggest that electrons from sulfide enter the respiratory chain via or at the -cytochrome-c oxidoreductase. Mitochondrial respiration in the presence of (or and ADP but without sulfide could be completely inhibited by rotenone, antimycin, and sulfide. |
1(0,0,0,1) | Details |
| 7873673 | Maklashina EO, Vinogradov AD: [Participation of the acceptor in the transition of complex I from an inactive to active state]. Biokhimiia. 1994 Nov;59(11):1638-45. Almost complete slow activation of the deactivated purified Complex I was observed after the steady-state cytochrome c reductase reaction turnovers catalyzed by the endogenous (tightly-bound) and contaminant Complex III. The rotenone-sensitive oxidase was reconstituted from bovine heart Complex I and Escherichia coli -oxidase. |
1(0,0,0,1) | Details |
| 7763312 | Anderson WM, Trgovcich-Zacok D: Carbocyanine dyes with long alkyl side-chains: broad spectrum inhibitors of mitochondrial electron transport chain activity. Biochem Pharmacol. 1995 May 11;49(9):1303-11. Certain indocarbocyanine, thiacarbocyanine, and oxacarbocyanine dyes possessing short alkyl side-chains (one to five carbons) are potent inhibitors of mammalian mitochondrial -ubiquinone reductase (EC 1.6.99.3) activity (Anderson et al., Biochem Pharmacol 41: 677-684, 1991; Anderson et al., Biochem Pharmacol 45: 691-696, 1993; Anderson et al., Biochem Pharmacol 45: 2115-2122, 1993), and act similarly to rotenone. In contrast to previous studies, the long alkyl side-chain carbocyanines exhibited a broad spectrum of inhibition of respiratory chain activity, affecting either oxidation of all three substrates or of and cytochrome c, rather than specific inhibition of mitochondrial -ubiquinone reductase activity, indicating that there could be multiple binding sites for these compounds. |
1(0,0,0,1) | Details |
| 16185262 | Tamiji S, Beauvillain JC, Mortier L, Jouy N, Tual M, Delaporte E, Formstecher P, Marchetti P, Polakowska R: Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation. J Invest Dermatol. 2005 Oct;125(4):647-58. In this study, we demonstrated that staurosporine, and rotenone induced apoptotic-like changes in the mitochondria, and early differentiation of keratinocytes without inducing apoptosis. Kinetics studies established that differentiation-related changes, including growth arrest, flattened morphology, stratification, and keratin 10 (K10) expression, were downstream of mitochondrial depolarization and proliferation, reactive species (ROS) production, and release of cytochrome c and apoptosis-inducing factor. |
1(0,0,0,1) | Details |
| 17855661 | Hsu YC, Lee HC, Ping YH, Liu TY, Lui WY, Chi CW: Mitochondria are an essential mediator of /cyclic 3',5'-monophosphate blocking of depletion induced cytotoxicity in human HepG2 cells. Mol Cancer Res. 2007 Sep;5(9):923-32. Furthermore, we found that rotenone and antimycin A (mitochondria complex I and III inhibitors, respectively) blocked SNP cytoprotection against depletion-induced cytotoxicity. Moreover, depletion decreased the expression of various mitochondrial proteins, including cytochrome c, complex I (NADH dehydrogenase), complex III (cytochrome c reductase), and heat shock protein 60; these depletion-induced effects were blocked by SNP. |
1(0,0,0,1) | Details |
| 10370869 | Zini R, Morin C, Bertelli A, Bertelli AA, Tillement JP: Effects of on the rat brain respiratory chain. Drugs Exp Clin Res. 1999;25(2-3):87-97. The rate of consumption by the different complexes was checked using rotenone (2 microM), (10 mM), antimycin A (1 microM), (KCN) (0.3 mM) and oligomycin (10 microM) to inhibit complexes II, III, IV, V and I, respectively. Moreover, enzyme activity determinations were checked as follows: the activities of complexes II-III were measured as the rate of cytochrome c reduction at 550 nm (37 degrees C) successively triggered either by (complexes II and III) or by decylubiquinol (DUQH2) (complex III), in the presence and in the absence of |
1(0,0,0,1) | Details |
| 15836612 | Votyakova TV, Reynolds IJ: Ca2+-induced permeabilization promotes free radical release from rat brain mitochondria with partially inhibited complex I. J Neurochem. 2005 May;93(3):526-37. In this study we investigated the effect of Ca2+ loads on ROS release from rat brain mitochondria with complex I partially inhibited by rotenone. ADP in combination with oligomycin decreased the loss of and cytochrome c and free radical generation. |
1(0,0,0,1) | Details |
| 207670 | Kenimer EA, Lapp DF: Effects of selected inhibitors on electron transport in Neisseria gonorrhoeae. J Bacteriol. 1978 May;134(2):537-45. The effects of selected electron transport inhibitors (amytal, rotenone, 2-heptyl-4-hydroxyquinoline, antimycin A1, and [KCN]) on electron transfer in whole-cell and sonically treated whole-cell preparations of N. gonorrhoeae were examined. Hence, N. gonorrhoeae appears to have an electron transport chain containing cytochrome c, two b-type cytochromes (one of which has an oxidase function), and possibly a- and d-type cytochromes. |
1(0,0,0,1) | Details |
| 17432597 | Shiriaeva AP, Baidiuk EV, Arkad'eva AV, Okovityi SV, Morozov VI, Sakuta GA: [Hepatocyte mitochondrion respiratory chain in rats with experimental toxic hepatitis]. Tsitologiia. 2007;49(2):125-32. Alterations of SCCR, -cytochrome c-reductase, cytochrome c oxidase and ATP-synthase activities have an adaptive nature to compensate for impaired NCCR function. Rotenone (the inhibitor of the I complex) decreased 27% consumption by pathological hepatocytes while dinitrophenol produced 37% cell respiration increase. |
1(0,0,0,1) | Details |
| 8031121 | Takamiya S, Wang H, Hiraishi A, Yu Y, Hamajima F, Aoki T: Respiratory chain of the lung fluke Paragonimus westermani: facultative anaerobic mitochondria. Arch Biochem Biophys. 1994 Jul;312(1):142-50. The specific activities of oxidoreductases composing the oxidase system, i.e., -ubiquinone and --cytochrome c oxidoreductase (complex II and complex II-III, respectively) and cytochrome c oxidase (complex IV), were compared in mitochondria from adult Paragonimus, bovine heart (an aerobic tissue), and muscle of adult Ascaris suum which possesses an anaerobic respiratory chain. |
1(0,0,0,1) | Details |
| 8505638 | Anderson JJ, Bravi D, Ferrari R, Davis TL, Baronti F, Chase TN, Dagani F: No evidence for altered muscle mitochondrial function in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1993 May;56(5):477-80. Likewise, activities of rotenone sensitive cytochrome c reductase, cytochrome c reductase, or cytochrome oxidase in muscle mitochondria were not significantly different between Parkinsonian and control subjects. |
0(0,0,0,0) | Details |
| 8944779 | Beattie DS, Howton MM: The presence of rotenone-sensitive NADH dehydrogenase in the long slender bloodstream and the procyclic forms of Trypanosoma brucei brucei. Eur J Biochem. 1996 Nov 1;241(3):888-94. |
0(0,0,0,0) | Details |
| 7016267 | Ishaque M, Adapoe C, Kato L: Energy coupling mechanisms in host-grown Mycobacterium lepraemurium. Can J Biochem. 1981 Feb;59(2):75-82. While the oxidation and associated esterification was markedly sensitive to rotenone and other flavoprotein inhibitors, these inhibitors had no effect, however, on the phosphorylation coupled to oxidation. |
0(0,0,0,0) | Details |
| 1668297 | Araya J, Aguilera AM, Bosco C: [The effect of dietary Omega 6 polyunsaturated fatty acids on the activity of enzymes associated with liver mitochondrial and placental function in rats]. Arch Latinoam Nutr. 1991 Mar;41(1):62-71. The low fat diet (15 g%) reduced the activity of insensitive rotenone- cytochrome c reductase. |
37(0,1,2,2) | Details |
| 3132077 | Ichiki T, Tanaka M, Nishikimi M, Suzuki H, Ozawa T, Kobayashi M, Wada Y: Deficiency of subunits of Complex I and mitochondrial encephalomyopathy. . Ann Neurol. 1988 Mar;23(3):287-94. In all patients, the content of subunits of Complex I was also reduced in parallel with the rotenone-sensitive -cytochrome c reductase activity. |
37(0,1,2,2) | Details |
| 1804136 | Anokhina IP, Gorkin VZ, Medvedev AE, Ovchinnikova LN, Khristolyubova NA: Studies on mitochondrial metabolic processes in offspring of alcoholized rats--I. Alcohol Alcohol. 1991;26(5-6):559-65. The MAO-dependent inhibition of rotenone-insensitive -cytochrome c-reductase and succinate dehydrogenase by biogenic amines, incubated with the mitochondrial fraction, was altered in the offspring of alcoholized animals as compared with control rats. |
37(0,1,2,2) | Details |
| 9824162 | Higuchi M, Proske RJ, Yeh ET: Inhibition of mitochondrial respiratory chain complex I by TNF results in cytochrome c release, membrane permeability transition, and apoptosis. Oncogene. 1998 Nov 12;17(19):2515-24. This hypothesis is supported by the following observations: (1) TNF and rotenone induced MPT and cytochrome c release; (2) TNF-induced complex I inhibition was observed prior to cytochrome c release and MPT induction; (3) MPT induction was inhibited by a caspase 3 inhibitor, z-DEVD-CH2F, and an antioxidant pyrrolidine dithiocarbamate (PDTC), whereas cytochrome c release was only inhibited by PDTC. |
33(0,1,1,3) | Details |
| 210759 | Halestrap AP: Stimulation of the respiratory chain of rat liver mitochondria between cytochrome c1 and cytochrome c by glucagon treatment of rats. Biochem J. 1978 Jun 15;172(3):399-405. Measurement of the cytochrome spectra under uncoupled conditions in the presence of and rotenone demonstrates a crossover between cytochromes c and c (1) when control mitochondria are compared with those from glucagon-treated rats, cytochrome c being more oxidized and cytochrome c (1) more reduced in control mitochondria. |
32(0,1,1,2) | Details |
| 1015305 | Radeva-Domustchieva D, Russanov E: Effect of exhaustive swimming on the oxidative phosphorylation and the activity of some enzymes in rat liver mitochondria. Acta Physiol Pharmacol Bulg. 1976;2(1):72-7. In liver mitochondria of control animals and of animals subjected to swimming for three hours experiments are made to determine the activities of rotenone-insensitive NAD.H-cytochrome c-oxireductase, -cytochrome c-oxireductase, MDH, SDH, ATP-ase and cytochrome oxidase, as well as uptake, respiratory control index and ADP/O ratio upon oxidation of and + |
32(0,1,1,2) | Details |
| 823748 | Schewe T, Hiebsch C, Halangk W: [Action of the systemic fungicide dexon on several NADH dehydrogenases] . Acta Biol Med Ger. 1975;34(11-12):1767-75. Soluble -cytochrome c-oxidoreductase (MAHLER) and rotenone-insensitive ubiquinone reductase are also inhibited by dexon. |
31(0,1,1,1) | Details |
| 7358642 | Ito A: Cytochrome b5-like hemoprotein of outer mitochondrial membrane: OM cytochrome b. J Biochem. 1980 Jan;87(1):73-80. Contribution of OM cytochrome b to rotenone-insensitive -cytochrome c reductase activity.. |
20(0,0,3,5) | Details |
| 14698482 | Diaz-Corrales FJ, Asanuma M, Miyazaki I, Ogawa N: Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line. Neurosci Lett. 2004 Jan 2;354(1):59-63. Rotenone-treated cells showed round nuclei, diffuse signals of the GA and cytosolic redistribution of cytochrome c. |
6(0,0,1,1) | Details |
| 2996532 | Niranjan BG, Avadhani NG, DiGiovanni J: Formation of benzo (alpha) pyrene metabolites and DNA adducts catalyzed by a rat liver mitochondrial monooxygenase system. Biochem Biophys Res Commun. 1985 Sep 16;131(2):935-42. The mitoplasts used in this study contained less than 1% microsomal marker enzymes: rotenone insensitive cytochrome c reductase and glucose-6-phosphatase. |
6(0,0,1,1) | Details |
| 6329280 | Suematsu E, Hirata M, Kuriyama H: Effects of cAMP- and -dependent protein kinases, and calmodulin on Ca2+ uptake by highly purified sarcolemmal vesicles of vascular smooth muscle. Biochim Biophys Acta. 1984 Jun 13;773(1):83-90. In these fractions, there was a high activity of 5'-nucleotidase, a putative marker enzyme of plasma membrane, and a low activity of rotenone insensitive -cytochrome c reductase a marker of sarcoplasmic reticulum. |
6(0,0,1,1) | Details |
| 3004406 | Hopewell R, Martin-Sanz P, Martin A, Saxton J, Brindley DN: Regulation of the translocation of phosphatidate phosphohydrolase between the cytosol and the endoplasmic reticulum of rat liver. Biochem J. 1985 Dec 1;232(2):485-91. The phosphohydrolase that associated with the membranes in the presence of [14C] or 1mM- coincided on Percoll gradients with the peak of rotenone-insensitive -cytochrome c reductase, and in the former case with a peak of 14C. |
6(0,0,1,1) | Details |
| 2457025 | Nisimoto Y, Tamura M, Lambeth JD: A -stimulated nucleotide oxidase from resting bovine neutrophil membranes. J Biol Chem. 1988 Aug 25;263(24):11657-63. Cytochrome c reduction was not inhibited by several mitochondrial respiratory chain inhibitors (azide, and rotenone) but was sensitive to thiol-reactive agents (p-chloromercuribenzoate and monoiodo The enzyme transferred electrons to cytochrome c, dichlorophenolindophenol, and nitro blue tetrazolium. |
2(0,0,0,2) | Details |
| 11490098 | Ko S, Kwok TT, Fung KP, Choy YM, Lee CY, Kong SK: Tumour necrosis factor induced an early release of and a late mitochondrial membrane depolarization in L929 cells. Biol Signals Recept. 2001 Sep-Oct;10(5):326-35. In the present study, we attempted to examine the role of O2-* in the regulation of mitochondrial membrane potential (Delta (Psi) m) and the release of cytochrome c (cyto c) in L929 cells after stimulation with TNF. The use of mitochondrial electron transport chain inhibitors such as antimycin A and rotenone could, respectively, potentiate or suppress the TNF-mediated release of O2-* and cytotoxicity. |
1(0,0,0,1) | Details |
| 4303729 | Boll M: [Enzymes of the electron-transport particles of Rhodospirillum rubrum: properties of and cytochrome c reductase] Arch Mikrobiol. 1968;64(1):85-102. |
1(0,0,0,1) | Details |
| 19562601 | Henderson JR, Swalwell H, Boulton S, Manning P, McNeil CJ, Birch-Machin MA: Direct, real-time monitoring of generation in isolated mitochondria. Free Radic Res. 2009 Sep;43(9):796-802. Epub 2009 Jun 25. This study reports the novel application of a cytochrome c functionalized amperometric sensor for monitoring [image omitted] generation in isolated mitochondrial fractions. |
1(0,0,0,1) | Details |
| 185865 | Muller W, Schewe T: [The systemic fungicide tridermorph as an inhibitor of the respiratory chain of electron transfer particles from beef heart mitochondria]. Acta Biol Med Ger. 1976;35(6):693-707. (N-tridecyl-2,6-dimethylmorpholine) inhibits both the -oxidase and the -cytochrome c oxydoreductase system of non-phosphorylating electron transfer particles from beef heart. The inhibition of the - oxydoreductase activity as well as the suppression of the -induced reduction of all cytochromes on the one hand and the insensitivity of the -ferricyanide oxydoreductase system on the other argue in favour of a site of action similar to rotenone. |
1(0,0,0,1) | Details |
| 9914819 | Lenaz G, Cavazzoni M, Genova ML, D'Aurelio M, Merlo Pich M, Pallotti F, Formiggini G, Marchetti M, Parenti Castelli G, Bovina C: Oxidative stress, antioxidant defences and aging. Biofactors. 1998;8(3-4):195-204. Treatment of cultured neuroblastoma cells with a radical initiator induced apoptosis; raise in peroxide and release of cytochrome c from mitochondria preceded collapse of mitochondrial potential and cell death. Complex I activity and its rotenone sensitivity decreased in brain cortex non-synaptic mitochondria from old rats; a 5 kb mitochondrial DNA deletion was found only in the old rats. |
1(0,0,0,1) | Details |
| 4341070 | Masuda Y, Kuchii M, Yamamoto H: [Cell membrane function. 4. Nippon Yakurigaku Zasshi. 1972 Mar;68(2):167-78. Enzymatic characterization of the -cytochrome c reductase of the cell membrane from normal and CC1-4 treated rat liver] |
1(0,0,0,1) | Details |
| 8285590 | Dexter DT, Sian J, Rose S, Hindmarsh JG, Mann VM, Cooper JM, Wells FR, Daniel SE, Lees AJ, Schapira AH, et al.: Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease. Ann Neurol. 1994 Jan;35(1):38-44. Rotenone-sensitive reductase activity (complex I) was reduced to levels intermediate between those in control subjects and those in patients with overt Parkinson's disease, but this change did not reach statistical significance. |
0(0,0,0,0) | Details |
| 5499970 | Gear AR: Inner- and outer-membrane enzymes of mitochondria during liver regeneration. Biochem J. 1970 Dec;120(3):577-87. The behaviour of the rotenone-insensitive, cytochrome c reductase did not parallel the other outer-membrane enzymes for intact mitochondria, but did so when assayed in highly purified fractions of outer membrane. |
0(0,0,0,0) | Details |
| 12821677 | Ling YH, Liebes L, Zou Y, Perez-Soler R: Reactive species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem. 2003 Sep 5;278(36):33714-23. Epub 2003 Jun 23. Co-incubation with rotenone and antimycin A, inhibitors of mitochondrial electron transport chain complexes I and III, or with cyclosporine A, an inhibitor of mitochondrial permeability transition pore, resulted in inhibition of bortezomib-induced ROS generation, increase in Delta psi m, and cytochrome c release. |
35(0,1,1,5) | Details |
| 3000462 | Balasiavichius RV, Toleikis AI, Prashkiavichius AK, Iasaitis AA: [Evaluation of structuro-functional heterogeneity of isolated mitochondria from the normal and the ischemic myocardium]. Biokhimiia. 1985 Oct;50(10):1685-93. In the presence of cytochrome c. a relatively high (260 +/- 26 ng at O/min . mg of protein) rate of rotenone-sensitive oxidation was observed, which was increased in ischemia. |
34(0,1,1,4) | Details |
| 532525 | Takaishi M, Shimizu T, Shishiba Y: Solubilization of -5'-deiodinase activity from rat liver microsome fraction. Acta Endocrinol. 1979 Dec;92(4):694-701. The extent of solubilization was compared with that of protein, rotenone insensitive cytochrome c reductase or NADH cytochrome b5 reductase, which have been shown to associate with microsomal membrane rather than luminar contents. |
18(0,0,3,3) | Details |
| 2415172 | Shol'ts KF, Mamaev DV: [Interaction of cytochrome c with mitochondrial proteins and cybacrone-dextran]. Biokhimiia. 1985 Nov;50(11):1877-83. This suggests that cytochrome c concentration in the intermembrane space of intact mitochondria is increased by salts, whereas the increase in ionic strength has a slight influence on the rates of oxidase and external rotenone-insensitive -oxidase of intact mitochondria. |
13(0,0,1,8) | Details |
| 213203 | Kennett FF, Weglicki WB: Lack of effect of methylprednisolone on lysosomal and microsomal enzymes after two hours of well-defined canine myocardial ischemia. Circ Res. 1978 Nov;43(5):759-68. Homogenates of these tissue samples were separated by ultracentrifugation into lysosome-rich and microsomal fractions and were analyzed for N-acetyl-beta-glusosaminidase (NAGA), beta-glucuronidase (beta-gluc), rotenone-insensitive--cytochrome c reductase (RINCR), and cytochrome oxidase. |
6(0,0,1,1) | Details |
| 6317478 | Kopeikina-Tsiboukidou L, Deliconstantinos G: Functional changes of rat brain mitochondrial enzymes induced by monomeric Int J Biochem. 1983;15(12):1403-7. The specific activity of the inner mitochondrial membrane enzyme -cytochrome c reductase was linearly decreased, while that of Rotenone-sensitive -cytochrome c reductase was exponentially increased, at different concentrations of |
6(0,0,1,1) | Details |
| 6317378 | Demant EJ: oxidation in submitochondrial particles protects respiratory chain activity against damage by adriamycin-Fe3+. Eur J Biochem. 1983 Dec 1;137(1-2):113-8. Protection by is strengthened by removal of cytochrome c from the submitochondrial particles and by antimycin A but abolished by rotenone. |
6(0,0,1,1) | Details |
| 4309122 | Shephard EH, Hubscher G: Phosphatidate biosynthesis in mitochondrial subfractions of rat liver. . Biochem J. 1969 Jun;113(2):429-40. Phosphatidate formation was measured in all subcellular fractions and subfractions and was compared with the distribution of succinate dehydrogenase, monoamine oxidase, rotenone-insensitive cytochrome c reductase, arylsulphatase, urate oxidase, arylesterase and glucose 6-phosphatase. 3. |
6(0,0,1,1) | Details |
| 16749863 | Souid AK, Penefsky HS, Sadowitz PD, Toms B: Enhanced cellular respiration in cells exposed to doxorubicin. . Mol Pharm. 2006 May-Jun;3(3):307-21. Doxorubicin executes topoisomerase II mediated apoptosis, a process known to result in mitochondrial dysfunction, such as the leakage of cytochrome c and the opening of mitochondrial permeability transition pores (PTP). The conclusion that both of the latter processes were products of oxidations in the mitochondrial respiratory chain was supported by the further observation that rotenone and inhibited consumption and substantially lowered ATP content in the treated and untreated cells. |
2(0,0,0,2) | Details |
| 15149325 | Zager RA, Johnson AC, Hanson SY: Proximal tubular cytochrome c efflux: determinant, and potential marker, of mitochondrial injury. Kidney Int. 2004 Jun;65(6):2123-34. METHODS: Isolated mouse proximal tubules (PT) were subjected to site 1 (rotenone; Rot), site 2 (antimycin A, AA), or site 3 (hypoxic) respiratory chain blockade (+/- 2 mmol/L to prevent plasma membrane disruption/cell death). |
2(0,0,0,2) | Details |
| 4394443 | Takesue S, Omura T: Immunological similarity between -cytochrome c reductases of mitochondrial outer membrane and microsomes. Biochem Biophys Res Commun. 1970 Jul 27;40(2):396-401. |
1(0,0,0,1) | Details |
| 11167513 | Piasecka M, Wenda-Rozewicka L, Ogonski T: Computerized analysis of cytochemical reactions for dehydrogenases and oxygraphic studies as methods to evaluate the function of the mitochondrial sheath in rat spermatozoa. Andrologia. 2001 Jan;33(1):1-12. These differences concerned the stimulation of oxidation by the lack of an effect of on phenazine methosulphate (an acceptor of electrons) oxidation and the lack of an effect of cytochrome c on oxidation. |
1(0,0,0,1) | Details |
| 990458 | Kamysheva AS: [Effect of restoration of light flashes on energy processes in the cerebral visual system of animals developing under conditions of light deprivation]. Biull Eksp Biol Med. 1976 Sep;82(9):1066-8. The rate of the electron transport in the area of cytochrome c -- cytochromoxidase succinic toxidase oxidation chain decreased at the period of restoration and approached the control level. |
1(0,0,0,1) | Details |
| 5497148 | Williams JN Jr, Thorp SL: Influence of degradative procedures, salts, respiratory inhibitors, and gramicidin on the binding of cytochrome c by liver mitochondria. Arch Biochem Biophys. 1970 Dec;141(2):622-31. |
1(0,0,0,1) | Details |
| 6282252 | Clark MG, Partick EJ, Patten GS, Crane FL, Low H, Grebing C: Evidence for the extracellular reduction of ferricyanide by rat liver. Biochem J. 1981 Dec 15;200(3):565-72. Oxidized cytochrome c was reduced by isolated hepatocytes in the presence of 1mm-KCN but at a rate less than that of the reduction of ferricyanide. 6. The low-affinity rate, present only in cell and broken cell preparations, was inhibited by 1mum-rotenone and 0.5mm-ferrocyanide, and stimulated by 0.1mm-KCN. |
1(0,0,0,1) | Details |
| 16657416 | Wilson SB, Bonner WD: Preparation and Some Properties of Submitochondrial Particles from Tightly Coupled Mung Bean Mitochondria. Plant Physiol. 1970 Jul;46(1):25-30. oxidation was slightly stimulated by cytochrome c, ATP, and ADP; oxidation was markedly increased by ATP, slightly by ADP and cytochrome c; and oxidation required the addition of NAD (+) oxidation is inhibited weakly by amytal, completely by antimycin A and KCN, but not by rotenone. |
0(0,0,0,0) | Details |
| 14699012 | Cherednichenko G, Zima AV, Feng W, Schaefer S, Blatter LA, Pessah IN: oxidase activity of rat cardiac sarcoplasmic reticulum regulates -induced release. Circ Res. 2004 Mar 5;94(4):478-86. Epub 2003 Dec 29. A significant contribution by mitochondria was excluded as oxidation by SR exhibited > 9-fold higher catalytic activity (8.8 micromol/mg protein per minute) in the absence of exogenous mitochondrial complex I or complex III (cytochrome c) electron acceptors, but was inhibited by rotenone and pyridaben (IC50=2 to 3 nmol/L), antimycin A (IC50=13 nmol/L), and diphenyleneiodonium (IC50=28 micromol/L). |
0(0,0,0,0) | Details |
| 10378416 | Chen M, Andersen LP, Zhai L, Kharazmi A: Characterization of the respiratory chain of Helicobacter pylori. FEMS Immunol Med Microbiol. 1999 Jun;24(2):169-74. The total insensitivity of activities of NADH dehydrogenase to rotenone and of -cytochrome c reductase to antimycin is indicative of the absence of the classical complex I of the electron transfer chain in this bacterium. |
32(0,1,1,2) | Details |
| 19682553 | Pan T, Rawal P, Wu Y, Xie W, Jankovic J, Le W: Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience. 2009 Dec 1;164(2):541-51. Epub 2009 Aug 12. Additionally, the results showed that rapamycin pretreatment diminished rotenone-induced accumulation of high molecular weight ubiquitinated bands, and reduced rotenone-induced increase of cytochrome c in cytosolic fraction and decreased mitochondrial marker cytochrome oxidase subunit IV (COX IV) in mitochondrial fraction. |
32(0,1,1,2) | Details |
| 6265441 | Bernardi P, Azzone GF: Cytochrome c as an electron shuttle between the outer and inner mitochondrial membranes. J Biol Chem. 1981 Jul 25;256(14):7187-92. Addition of exogenous to rotenone- and antimycin A-treated mitochondria, in 125 mM KCl, results in rates of uptake of 0.5-1 and 10-12 nanoatoms of X mg protein-1 X min-1 in the absence and presence of cytochrome c, respectively. |
13(0,0,1,8) | Details |
| 19351880 | Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, Chu CT, Greenamyre JT, Kagan VE: Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. J Biol Chem. 2009 Jun 5;284(23):15951-69. Epub 2009 Apr 7. Co-localization of Syn with cytochrome c was detected in aggregates formed upon proapoptotic stimulation of SH-SY5Y and HeLa cells and in dopaminergic substantia nigra neurons of rotenone-treated rats. |
12(0,0,1,7) | Details |
| 1904460 | Harbord MG, Hwang PA, Robinson BH, Becker LE, Hunjan A, Murphy EG: Infant-onset progressive myoclonus epilepsy. . J Child Neurol. 1991 Apr;6(2):134-42. Respiratory-chain enzyme studies were performed on five samples and in three children (all of whom had a history of elevated lactate in serum or cerebrospinal fluid), there were low levels of rotenone-sensitive cytochrome c reductase characteristic of a defect in the complex I part of the respiratory-chain pathway. |
6(0,0,1,1) | Details |
| 1488063 | Wu CM, Matsuoka T, Takemitsu M, Goto Y, Nonaka I: An experimental model of mitochondrial myopathy: -induced myopathy and administration. Muscle Nerve. 1992 Nov;15(11):1258-64. Rotenone-sensitive -cytochrome-c reductase as well as COX activities were markedly reduced, while -cytochrome-c reductase was less severely, but significantly, affected. |
6(0,0,1,1) | Details |
| 213202 | Kennett FF, Weglicki WB: Effects of well-defined ischemia on myocardial lysosomal and microsomal enzymes in a canine model. Circ Res. 1978 Nov;43(5):750-8. In addition, about 45% of the total activity of the microsomal marker enzyme, rotenone-insensitive cytochrome C reductase (RINCR), was found in the 140,000 g pellet of H-control tissue (9.9 micronmol/min per g); this activity fell to 8.1 micronmol/min per g in M-ischemic areas (P less than 0.001) and to 5.3 micronmol/min per g in L-ischemic areas (P less than 0.001). |
6(0,0,1,1) | Details |
| 3191526 | Sandri G, Siagri M, Panfili E: Influence of Ca2+ on the isolation from rat brain mitochondria of a fraction enriched of boundary membrane contact sites. Cell Calcium. 1988 Aug;9(4):159-65. Three fractions were obtained by this technique, which were identified by measuring the relative specific activities of marker enzymes, namely -cytochrome c reductase; -cytochrome c reductase (rotenone insensitive); hexokinase and glutathione transferase, for the inner and outer membranes and contact sites, respectively. |
6(0,0,1,1) | Details |
| 16343695 | Choi HJ, Lee SY, Cho Y, No H, Kim SW, Hwang O: causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochem Int. 2006 Mar;48(4):255-62. Epub 2005 Dec 15. BH4 appears to be different from rotenone and MPP (+), the synthetic compounds used to generate Parkinson models, in its effect on complex IV. BH4 also induces the release of mitochondrial cytochrome c. |
2(0,0,0,2) | Details |
| 10597238 | Suzuki S, Higuchi M, Proske RJ, Oridate N, Hong WK, Lotan R: Implication of mitochondria-derived reactive species, cytochrome C and caspase-3 in N-(4-hydroxyphenyl) retinamide-induced apoptosis in cervical carcinoma cells. Oncogene. 1999 Nov 4;18(46):6380-7. Rotenone, an MRC complex I inhibitor was less effective and azide, an MRC complex IV inhibitor, exhibited a marginal effect. |
2(0,0,0,2) | Details |
| 215122 | Ragan CI, Heron C: The interaction between mitochondrial NADH-ubiquinone oxidoreductase and -cytochrome c oxidoreductase. Biochem J. 1978 Sep 15;174(3):783-90. Experiments on the inhibition of the -cytochrome c oxidoreductase activity of mixtures of Complexes I and III by rotenone and antimycin indicate that electron transfer between a unit of Complex I-Complex III and extra molecules of Complexes I or III does not contribute to the overall rate of cytochrome c reduction. 3. |
2(0,0,0,2) | Details |
| 403946 | Kilpatrick L, Erecinska M: Mitochondrial respiratory chain of Tetrahymena pyriformis. Biochim Biophys Acta. 1977 May 11;460(2):346-63. The respiration is more than 90% inhibited with 1 mM while antimycin A and rotenone inhibit at concentrations of 1000-fold higher than those effective in mammalian mitochondria. In the cytochrome bc1 region of the chain a cytochrome c was present with an Em7.2 of 0.225 V and two components with absorption maxima at 560 nm and the half-reduction potential values of -0.065 and -0.15 V at pH 7.2. |
1(0,0,0,1) | Details |
| 4354786 | Kiessling KH, Pilstrom L: Cytochrome c stimulated oxidation of by liver mitochondria. Biochem Pharmacol. 1973 Sep 15;22(18):2229-35. |
1(0,0,0,1) | Details |
| 2710162 | Campbell T, Rubin N, Komuniecki R: -dependent energy generation in Ascaris suum mitochondria. . Mol Biochem Parasitol. 1989 Feb;33(1):1-12. -dependent phosphorylation was stimulated aerobically and this stimulation was due almost entirely to a site I, rotenone-sensitive, phosphorylation. A possible role for cytochrome c peroxidase in A. suum mitochondrial metabolism is discussed. |
1(0,0,0,1) | Details |
| 12730670 | Djavaheri-Mergny M, Wietzerbin J, Besancon F: induces apoptosis in Ewing sarcoma cells through mitochondrial peroxide production. Oncogene. 2003 May 1;22(17):2558-67. Here, we report that 2-methoxy- (2-Me), a natural metabolite, induced a caspase-dependent apoptosis of Ewing sarcoma-derived cells independently of their p53 status. 2-Me-induced apoptosis occurred through the mitochondrial death pathway as evidenced by reduction of the mitochondrial transmembrane potential, cytochrome c release and caspase-9 activation. Rotenone, an inhibitor of the mitochondrial respiratory chain, abolished both apoptosis and H (2) O (2) production, thereby identifying mitochondria as the source of H (2) O (2). |
1(0,0,0,1) | Details |
| 9989825 | Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML: peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive species and the activation of NF-kappaB. Oncogene. 1999 Jan 21;18(3):747-57. peroxide-treatment of T-cells resulted in the formation of mitochondrial permeability transition pores, a rapid decrease of the mitochondrial transmembrane potential delta psi (m) and the release of Cytochrome C. Inhibition of the mitochondrial permeability transition by bongkrekic acid (BA), or interference with the mitochondrial electron transport system by rotenone or prevented the cytotoxic effect of H2O2. |
1(0,0,0,1) | Details |
| 9593899 | Almeida A, Heales SJ, Bolanos JP, Medina JM: neurotoxicity is associated with -mediated mitochondrial dysfunction and depletion. Brain Res. 1998 Apr 20;790(1-2):209-16. exposure (0.1 mM and 1 mM) followed by 24 h of incubation caused the inhibition of -cytochrome c reductase (20-25%) and cytochrome c oxidase (31%) activities in the surviving neurones, without affecting - reductase activity. |
1(0,0,0,1) | Details |
| 16292513 | Lee SJ, Youn YC, Han ES, Lee CS: Depressant effect of mitochondrial respiratory complex inhibitors on proteasome inhibitor-induced mitochondrial dysfunction and cell death in PC12 cells. Neurochem Res. 2005 Sep;30(9):1191-200. The addition of rotenone (inhibitor of respiratory complex I), 3-nitropropionic acid (complex II inhibitor), harmine (inhibitor of complexes I and II) and cyclosporin A (CsA, an inhibitor of the mitochondrial permeability transition) reduced the nuclear damage, loss in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive species and depletion of in differentiated PC12 cells treated with MG132, a proteasome inhibitor. The addition of rotenone (inhibitor of respiratory complex I), 3-nitropropionic acid (complex II inhibitor), harmine (inhibitor of complexes I and II) and cyclosporin A (CsA, an inhibitor of the mitochondrial permeability transition) reduced the nuclear damage, loss in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive species and depletion of in differentiated PC12 cells treated with MG132, a proteasome inhibitor. |
1(0,0,0,1) | Details |
| 20203294 | Ranzato E, Biffo S, Burlando B: Selective Toxicity to Malignant Mesothelioma: A Redox Trojan Mechanism. Am J Respir Cell Mol Biol. 2010 Mar 4. Mesothelioma cells showed much higher production (revealed by cytochrome c reduction assay) and NOX4 expression (revealed by Western blot) than mesothelial cells. Two inhibitors of cellular sources, apocynin and rotenone, reduced cytotoxicity and the -induced rise in rhodamine fluorescence. |
1(0,0,0,1) | Details |
| 2828610 | Aitken RJ, Clarkson JS: Cellular basis of defective sperm function and its association with the genesis of reactive species by human spermatozoa. J Reprod Fertil. 1987 Nov;81(2):459-69. This activity was dependent upon the presence of in the external medium and was unaffected by the mitochondrial inhibitors, oligomycin, antimycin and rotenone. Studies with scavengers of reactive species revealed that, while reagents directed against singlet and the were without effect, cytochrome C reduced the response to A23187 by about 50%, suggesting that the radical is a major product of the activated human spermatozoon. |
1(0,0,0,1) | Details |
| 12566073 | Fang J, Beattie DS: External alternative NADH dehydrogenase of Saccharomyces cerevisiae: a potential source of Free Radic Biol Med. 2003 Feb 15;34(4):478-88. Three rotenone-insensitive NADH dehydrogenases are present in the mitochondria of yeast Saccharomyces cerevisiae, which lack complex I. formation, determined by EPR and acetylated cytochrome c reduction in mitochondria was stimulated by antimycin A, and partially inhibited by myxothiazol and stigmatellin. |
1(0,0,0,1) | Details |
| 17123556 | Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN: Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007 Mar;52(3):827-35. Epub 2006 Nov 22. In addition, Rg1 prevented cytochrome c release from the mitochrondrial membrane and increased the phosphorylation inhibition of the pro-apoptotic protein Bad through activation of the PI3K/Akt pathway. |
1(0,0,0,1) | Details |
| 411483 | Crowder SE, Ragan CI: Effects of proteolytic digestion by chymotrypsin on the structure and catalytic properties of - oxidoreductase from bovine heart mitochondria. Biochem J. 1977 Aug 1;165(2):295-301. Incubation of NADH-ubiquinone oxidoreductase (Complex I) with chymotrypsin caused loss of rotenone-sensitive reduction and an increase in rotenone-insensitive reduction. 2. |
0(0,0,0,0) | Details |
| 2174736 | Modica-Napolitano JS, Joyal JL, Ara G, Oseroff AR, Aprille JR: Mitochondrial toxicity of cationic photosensitizers for photochemotherapy. Cancer Res. 1990 Dec 15;50(24):7876-81. With photoirradiation VB-BO was also shown to inhibit rotenone-sensitive -cytochrome c reductase activity, but it had no effect on -cytochrome c reductase activity. |
0(0,0,0,0) | Details |
| 15659217 | Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA: Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J Neurochem. 2005 Feb;92(3):462-76. |
0(0,0,0,0) | Details |
| 6275889 | Bernardi P, Azzone GF: ATP synthesis during exogenous oxidation. Biochim Biophys Acta. 1982 Jan 20;679(1):19-27. Part of ATP synthesis is independent of exogenous and cytochrome c, and is inhibited by rotenone and antimycin A, and is therefore due to oxidation of endogenous substrates. |
113(1,2,2,3) | Details |
| 8350660 | Lemeshko VV, Shekh VE: Hypotonic fragility of outer membrane and activation of external pathway of oxidation in rat liver mitochondria are increased with age. Mech Ageing Dev. 1993 May;68(1-3):221-33. Research on the rate of rotenone-insensitive oxidation with respect to the osmotic pressure, the ionic strength of the medium, the presence of Mg2+ ions and cytochrome c in the medium has demonstrated a considerable increase in the hypotonic fragility of the outer membrane of liver mitochondria with age in male rats. |
112(1,2,2,2) | Details |
| 11527970 | Chauvin C, De Oliveira F, Ronot X, Mousseau M, Leverve X, Fontaine E: Rotenone inhibits the mitochondrial permeability transition-induced cell death in U937 and KB cells. J Biol Chem. 2001 Nov 2;276(44):41394-8. Epub 2001 Aug 29. Consistent with PTP regulation by electron flux through complex I, the effect of rotenone persisted after oxidation of nucleotides by duroquinone. tert-butyl hydroperoxide induced PTP opening in intact cells (as shown by mitochondrial permeabilization to calcein and as well as cytochrome c release and cell death. |
31(0,1,1,1) | Details |
| 7877728 | Cafe C, Torri C, Gatti S, Adinolfi D, Gaetani P, Rodriguez Y Baena R, Marzatico F: Changes in non-synaptosomal and synaptosomal mitochondrial membrane-linked enzymatic activities after transient cerebral ischemia. Neurochem Res. 1994 Dec;19(12):1551-5. Non-synaptosomal and synaptosomal mitochondrial membrane-linked enzymatic activities, -cytochrome c reductase rotenone insensitive (marker of the outer membrane) and cytochrome oxidase (marker of the inner membrane), were measured in rat brain hippocampus and striatum immediately after and 1, 4 and 7 days following the induction of complete transient ischemia (15 min) by the four vessel occlusion method. |
31(0,1,1,1) | Details |
| 8135551 | Kukielka E, Dicker E, Cederbaum AI: Increased production of reactive species by rat liver mitochondria after chronic treatment. Arch Biochem Biophys. 1994 Mar;309(2):377-86. The activity of the rotenone-insensitive -cytochrome c reductase, an enzyme of the outer mitochondrial membrane, was increased 40 to 60% by the treatment. |
12(0,0,2,2) | Details |
| 656472 | Wuytack F, Landon E, Fleischer S, Hardman JG: The accumulation in a microsomal fraction from porcine coronary artery smooth muscle. Biochim Biophys Acta. 1978 May 3;540(2):253-69. Rotenone-insensitive -cytochrome c reductase and phosphotransferase, two putative markers for internal membranes, give distinct banding patterns on on isopycnic centrifugation, indicating different intracellular localization. 6. |
12(0,0,2,2) | Details |
| 1260063 | Babitch JA, Breithaupt TB, Chiu TC, Garadi R, Helseth DL: Preparation of chick brain synaptosomes and synaptosomal membranes. . Biochim Biophys Acta. 1976 Apr 16;433(1):75-89. Purity of the subcellular and subsynaptosomal fractions was monitored by electron microscopy and measurements of ferrocytochrome c: oxidoreductase (EC 1.9.3.)), monoamine: oxidoreductase (deaminating) EC 1.4.3.4), rotenone-insensitive cytochrome c oxidoreductase (EC 1.6.99.3), cytochrome c oxidoreductase (EC 1.6.99.1), orthophosphoric monoester phosphohydrolase (EC 3.1.3.2), ATP phosphohydrolase (EC 3.6.1.4), and levels of RNA. |
6(0,0,1,1) | Details |
| 12496265 | Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, Robinson JP: Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive species production. J Biol Chem. 2003 Mar 7;278(10):8516-25. Epub 2002 Dec 20. Rotenone-induced apoptosis was confirmed by DNA fragmentation, cytochrome c release, and caspase 3 activity. |
6(0,0,1,1) | Details |
| 1337280 | Chapman JC, Waterhouse TB, Michael SD: Changes in mitochondrial and microsomal 3 beta-hydroxysteroid dehydrogenase activity in mouse ovary over the course of the estrous cycle. Biol Reprod. 1992 Dec;47(6):992-7. To ascertain whether the increase in mitochondrial HSD activity at diestrus could be due to a preferential induction of enzyme, its SA and the SA of a mitochondrial inner membrane enzyme, cytochrome C oxidase, were compared to the SA of a mitochondrial outer membrane enzyme, rotenone-insensitive cytochrome C reductase. |
6(0,0,1,1) | Details |
| 3134026 | Tanaka M, Nishikimi M, Suzuki H, Ozawa T, Ichiki T, Kobayashi M, Wada Y: Variation in the levels of complex I subunits among tissues in a patient with mitochondrial encephalomyopathy and renal dysfunction. Biochem Int. 1987 Apr;14(4):735-9. Rotenone-sensitive -cytochrome c reductase activity was decreased in all the tissues examined, but the degree of deficiency varied from tissue to tissue. |
6(0,0,1,1) | Details |
| 2827635 | Reed JS, Ragan CI: The effect of rate limitation by cytochrome c on the redox state of the pool in reconstituted cytochrome c reductase. Biochem J. 1987 Nov 1;247(3):657-62. We show that, in such a system, the dependence of activity (varied by inhibition with rotenone) on the steady-state level of reduction is indeed non-linear and very closely accounted for by the theory. |
2(0,0,0,2) | Details |
| 12551850 | Pei W, Liou AK, Chen J: Two caspase-mediated apoptotic pathways induced by rotenone toxicity in cortical neuronal cells. FASEB J. 2003 Mar;17(3):520-2. Epub 2003 Jan 22. Although these two pathways can be attributed to the loss of mitochondrial integrity, the triggers for these pathways are likely due to two separate subsequent events (the release of cytochrome c and the emergence of mitochondrial permeability transition [MPT]). |
2(0,0,0,2) | Details |
| 3024618 | West IC, Mitchell R, Moody AJ, Mitchell P: translocation by cytochrome oxidase in (antimycin + myxothiazol)-treated rat liver mitochondria using ferrocyanide or hexammineruthenium as electron donor. Biochem J. 1986 May 15;236(1):15-21. When O2 was injected into an anaerobic suspension of valinomycin-treated rat liver mitochondria inhibited with rotenone, antimycin, and myxothiazol, a small amount of O2 (0.23-0.33 ng-atom of O/mg of protein) was reduced extremely rapidly (within the 2 s time-resolution of the electrode). When 2 mM-Fe (CN) 6 (4-) was present to re-reduce endogenous cytochrome c, O2 consumption was still biphasic but the second phase of O2 consumption was very much more rapid [600 nequiv. |
1(0,0,0,1) | Details |
| 9804614 | Leist M, Volbracht C, Fava E, Nicotera P: 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Mol Pharmacol. 1998 Nov;54(5):789-801. The neurotoxin 1-methyl-4-phenylpyridinium (MPP+) and other mitochondrial inhibitors (e.g., rotenone or 3-nitropropionic acid) elicited apoptosis in cerebellar granule cell cultures via stimulation of autocrine excitotoxicity. Cell death, increase in intracellular Ca2+ concentration, release of cytochrome c, and all biochemical and morphological signs of apoptosis were prevented by blockade of the N-methyl-D-aspartate receptor with noncompetitive, -site or -site inhibitors. |
1(0,0,0,1) | Details |
| 10366439 | Leist M, Single B, Naumann H, Fava E, Simon B, Kuhnle S, Nicotera P: Inhibition of mitochondrial ATP generation by switches apoptosis to necrosis. Exp Cell Res. 1999 Jun 15;249(2):396-403. In contrast, depleting intracellular ATP with rotenone, an inhibitor of mitochondrial complex I mimicked the effect of NO. In the presence of NO, release of mitochondrial cytochrome c was delayed and activation of execution caspases was prevented. |
1(0,0,0,1) | Details |
| 17504811 | Guidarelli A, Cerioni L, Cantoni O: Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial formation and permeability transition evoked by J Cell Sci. 2007 Jun 1;120(Pt 11):1908-14. Epub 2007 May 15. Here we show that formation of H2O2 and DNA damage are suppressed by inhibition of complex I (by rotenone) or formation (by myxothiazol), as well as by a variety of manipulations preventing either the mobilization of Ca2+ or its mitochondrial accumulation. H2O2 formation was paralleled by, and causally linked to, the loss of mitochondrial membrane potential associated with the mitochondrial release of cytochrome c and AIF, and with the mitochondrial accumulation of Bax. |
1(0,0,0,1) | Details |
| 7356983 | Martens ME, Jankulovska L, Neymark MA, Lee CP: Impaired substrate utilization in mitochondria from strain 129 dystrophic mice. Biochim Biophys Acta. 1980 Feb 8;589(2):190-200. We concluded from these results that skeletal muscle mitochondria from strain 129 dystrophic mice possess impairments in substrate utilization which may result from (1) an abnormality in the transfer of electrons on the substrate side of in the case of oxidation; (2) a defect on the path of electron flow from to cytochrome c, and (3) a deficiency of NAD+ in the case of NAD+-linked substrates. |
1(0,0,0,1) | Details |
| 1318345 | Ishaque M: Energy generation mechanisms in the in vitro-grown Mycobacterium lepraemurium. Int J Lepr Other Mycobact Dis. 1992 Mar;60(1):61-70. However, in the presence of added cytochrome c was coupled to ATP synthesis and yielded a P/O ratio of 0.12. ATP generation coupled to oxidation was completely inhibited by the flavoprotein inhibitors, such as rotenone and amytal; these inhibitors had no effect, however, on ATP synthesis associated with oxidation. |
1(0,0,0,1) | Details |
| 39543 | Takeshige K, Minakami S: - and -dependent formation of anions by bovine heart submitochondrial particles and -ubiquinone reductase preparation. Biochem J. 1979 Apr 15;180(1):129-35. The reaction was inhibited by treatment of the preparation with p-hydroxymercuribenzoate and stimulated by treatment with rotenone. |
0(0,0,0,0) | Details |
| 16678157 | Lai JS, Zhao C, Warsh JJ, Li PP: Cytoprotection by lithium and varies between cell types and cellular stresses. Eur J Pharmacol. 2006 Jun 6;539(1-2):18-26. Epub 2006 Apr 5. Pretreatment of SH-SY5Y cells for 7 days, but not 1 day, with 1 mM of lithium or 0.6 mM of significantly reduced rotenone and H2O2-induced cytotoxicity, cytochrome c release and caspase-3 activation, and increased Bcl-2 levels. |
0(0,0,0,0) | Details |
| 213108 | Feo F, Canuto RA, Garcea R, Brossa O: The role of lipid-protein interactions in -cytochrome c reductase (rotenone-insensitive) of rat liver mitochondria. Biochim Biophys Acta. 1978 Oct 11;504(1):1-14. |
99(0,3,4,4) | Details |
| 3571184 | Nishino H, Ito A: Subcellular distribution of OM cytochrome b-mediated -semidehydroascorbate reductase activity in rat liver. J Biochem. 1986 Dec;100(6):1523-31. The ratio of the OM cytochrome b-mediated activities of -SDA reductase to rotenone-insensitive -cytochrome c reductase varied among these tissues. |
93(0,3,3,3) | Details |
| 1664494 | Benzi G, Curti D, Pastoris O, Marzatico F, Villa RF, Dagani F: Sequential damage in mitochondrial complexes by peroxidative stress. Neurochem Res. 1991 Dec;16(12):1295-302. The cerebral peroxidative stress induces: (a) initially, a decrease in brain GSH concentration concomitant with a decrease in the mitochondrial activity of cytochrome oxidase of aa3-type (complex IV), without changes in and cytochrome b populations; (b) subsequently, an alteration in the transfer molecule cytochrome c and, finally, in rotenone-sensitive -cytochrome c reductase (complex I) and succinate dehydrogenase (complex II). |
88(1,1,2,3) | Details |
| 18856204 | Lukyanova LD, Dudchenko AM, Tsybina TA, Germanova EL, Tkachuk EN, Erenburg IV: Effect of intermittent normobaric hypoxia on kinetic properties of mitochondrial enzymes. Bull Exp Biol Med. 2007 Dec;144(6):795-801. Low resistant animals were characterized by more effective functioning of rotenone-sensitive -cytochrome C reductase and -cytochrome C reductase under conditions of increased reduction status of the cell. |
31(0,1,1,1) | Details |
| 2544141 | Alderson BH, Volpe P: Distribution of endoplasmic reticulum and calciosome markers in membrane fractions isolated from different regions of the canine brain. Arch Biochem Biophys. 1989 Jul;272(1):162-74. Markers of endoplasmic reticulum (glucose-6-phosphate phosphatase and rotenone-insensitive cytochrome c reductase) and markers of the 1,4,5-trisphosphate (IP3)-sensitive Ca2+ store ([3H] IP3 binding and IP3-induced Ca2+ release) were measured. |
31(0,1,1,1) | Details |
| 223663 | Comte J, Gautheron DC: The markers of pig heart mitochondrial sub-fractions : I. - The dual location of -cytochrome c reductase in outer membrane and microsomes. Biochimie. 1978;60(11-12):1289-98. The properties of mitochondrial and microsomal rotenone-insensitive - and -cytochrome c reductases were studied. |
9(0,0,1,4) | Details |
| 10781794 | Lemeshko VV: Mg (2+) induces intermembrane electron transport by cytochrome c desorption in mitochondria with the ruptured outer membrane. FEBS Lett. 2000 Apr 21;472(1):5-8. We showed that Mg (2+) significantly stimulated IMET insensitive to rotenone-antimycin A-myxothiazol in mitochondria with the hypotonically damaged outer membrane, even in the absence of exogenous cytochrome c. |
9(0,0,1,4) | Details |
| 182253 | Hostetler KY, Zenner BD, Morris HP: Abnormal membrane phospholipid content in subcellular fractions from the Morris 7777 hepatoma. Biochim Biophys Acta. 1976 Aug 23;441(2):231-8. Mitochondrial and microsomal fractions were prepared from normal rat liver and the Morris 7777 hepatoma and characterized by the use of the marker enzymes, succinate dehydrogenase and rotenone-insensitive -cytochrome c reductase. 2. |
6(0,0,1,1) | Details |
| 12564110 | Ohmoto N, Fujiwara Y, Kibira S, Kobayashi M, Saito T, Miura M: [Cardiomyopathy showing progression from diffuse left ventricular hypertrophy to dilated phase associated with mitochondrial DNA point mutation A3243G: A case report]. J Cardiol. 2003 Jan;41(1):21-7. Mitochondrial respiratory enzyme analysis in gastrocnemius muscle tissue indicated a partial deficiency of rotenone-sensitive cytochrome C reductase. |
6(0,0,1,1) | Details |
| 177046 | La Monica RF, Marrs BL: The branched respiratory system of photosynthetically grown Rhodopseudomonas capsulata. Biochim Biophys Acta. 1976 Mar 12;423(3):431-9. In this category were the actions of rotenone on oxidase, antimycin A on cytochrome c reductase and, in M6 and Z-1, on N,N,N'N'-tetramethyl-p-phenylenediamine oxidase. |
6(0,0,1,1) | Details |
| 1203323 | Bouhnik J, Michel O, Francois D, Clot JP, Michel R: [Effects of thyroidectomy of the rat on the structure and functions of skeletal muscle mitochondria]. Biochimie. 1975;57(6-7):779-86. The activities of mitochondrial enzymes were in general slightly affected by thyroidectomy except for cytochrome c reductase and rotenone sensitive cytochrome c reductase which were decreased and for dehydrogenase activity which was increased. |
6(0,0,1,1) | Details |
| 12846980 | Fiskum G, Starkov A, Polster BM, Chinopoulos C: Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease. Ann N Y Acad Sci. 2003 Jun;991:111-9. Neurotoxins that induce parkinsonian neuropathology, such as MPP (+) and rotenone, stimulate production at complex I of the electron transport chain and also stimulate free radical production at proximal redox sites including mitochondrial matrix dehydrogenases. Interactions between Bax and BH3 death domain proteins such as tBid result in Bax membrane integration, oligomerization, and permeabilization of the outer membrane to intermembrane proteins such as cytochrome c. |
5(0,0,0,5) | Details |
| 18602972 | Choi EJ, Han JH, Lee CS: Prostaglandin analogue misoprostol attenuates neurotoxin 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells. Brain Res Bull. 2008 Jul 3. Treatment with misoprostol significantly attenuated the MPP (+)-induced mitochondrial membrane permeability change that leads to the increase in pro-apoptotic Bax and Cytochrome c levels, and subsequent caspase-3 activation. Misoprostol significantly attenuated another parkinsonian neurotoxin rotenone-induced cell death. |
2(0,0,0,2) | Details |
| 6035525 | Streichman S, Avi-Dor Y: The effect of osmotic 'shock' on the swelling pattern and respiratory control of rat-liver mitochondria. Biochem J. 1967 Jul;104(1):71-7. It was shown that cytochrome c is lost from ;shocked' mitochondria when they come into contact with the tris buffer present in the assay medium, and that the changes observed in the pattern of swelling, as well as in respiratory control, are directly connected with this loss of cytochrome c. 5. |
2(0,0,0,2) | Details |
| 17314199 | Yim SB, Park SE, Lee CS: Protective effect of glycyrrhizin on 1-methyl-4-phenylpyridinium-induced mitochondrial damage and cell death in differentiated PC12 cells. J Pharmacol Exp Ther. 2007 May;321(2):816-22. Epub 2007 Feb 21. MPP+ induced the nuclear damage, the changes in the mitochondrial membrane permeability, leading to the cytochrome c release and caspase-3 activation, the formation of reactive species, and the depletion of (GSH) in differentiated PC12 cells. The protective effect of licorice compounds was also detected in the rotenone-treated PC12 cells. |
1(0,0,0,1) | Details |
| 6206464 | von Ruecker AA, Bertele R, Harms HK: metabolism and cystic fibrosis: mitochondrial abnormalities suggest a modification of the mitochondrial membrane. Pediatr Res. 1984 Jul;18(7):594-9. Furthermore, the average activities of oxidase, - and -cytochrome c reductase were 77, 58, and 48% higher in CF mitochondria, respectively. |
1(0,0,0,1) | Details |
| 18077608 | Chen Q, Moghaddas S, Hoppel CL, Lesnefsky EJ: Ischemic defects in the electron transport chain increase the production of reactive species from isolated rat heart mitochondria. Am J Physiol Cell Physiol. 2008 Feb;294(2):C460-6. Epub 2007 Dec 12. Cardiac ischemia decreases complex III activity, cytochrome c content, and respiration through cytochrome oxidase in subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). With as substrate in the presence of rotenone, H (2) O (2) increased by 272 +/- 22% and 171 +/- 21% in SSM and IFM, respectively, after ischemia. |
1(0,0,0,1) | Details |
| 5062477 | Wu CS, Duffy P, Brown WD: Interaction of myoglobin and cytochrome C. J Biol Chem. 1972 Mar 25;247(6):1899-903. |
1(0,0,0,1) | Details |
| 2321971 | Bolter CJ, Chefurka W: Extramitochondrial release of peroxide from insect and mouse liver mitochondria using the respiratory inhibitors phosphine, myxothiazol, and antimycin and spectral analysis of inhibited cytochromes. Arch Biochem Biophys. 1990 Apr;278(1):65-72. Other respiratory inhibitors, antimycin, myxothiazol, and rotenone were used with insect mitochondria. peroxide was measured spectrophotometrically using yeast cytochrome c peroxidase as an indicator. |
1(0,0,0,1) | Details |
| 1879373 | Hall PF, Yanagibashi K, Kobayashi Y: Synthesis of by mitochondria and homogeneous 11 beta-hydroxylase from beef and pig. Endocr Res. 1991;17(1-2):135-49. To determine the influence of the mitochondrial membrane from glomerulosa and fasciculata on the activities of 11 beta-hydroxylase we examined the activities of rotenone-insensitive reductase enzymes in mitochondria from the two zones. Semidehydroxyascorbate reductase and -cytochrome C reductase activities are considerably more active in glomerulosa than in fasciculata mitochondria. |
1(0,0,0,1) | Details |
| 7994564 | Chen CL, Sangiah S, Yu CA, Chen H, Berlin KD, Garrison GL, Scherlag BJ, Lazzara R: Effects of novel antiarrhythmic agents, BRB-I-28 and its derivatives, on the heart mitochondrial respiratory chain and sarcoplasmic reticulum Ca (2+)-ATPase. Res Commun Mol Pathol Pharmacol. 1994 Aug;85(2):193-208. The site of inhibition of BRB-I-28 and its derivatives on the respiratory chain was localized between flavoprotein n (FPn) and which is similar to the effect of rotenone and several other antiarrhythmic drugs such as amiodarone, etc. |
0(0,0,0,0) | Details |
| 1171697 | Wang CC: Studies of the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. Biochim Biophys Acta. 1975 Aug 11;396(2):210-9. The mitochondrial respiration was inhibited by azide, antimycin A, and 2-heptyl-4-hydroxyquinoline-N-oxide, but was relatively resistant to rotenone and amytal. |
0(0,0,0,0) | Details |
| 8592781 | Lemeshko VV, Shekh VE, Aleksenko TV: [Intermembrane electron transport in the dynamics of high-amplitude swelling of rat liver mitochondria]. Ukr Biokhim Zh. 1995 Mar-Apr;67(2):28-34. The rate of exogenous oxidation was determined fluorimetrically in the presence of 4 microM cytochrome c in the medium after the inhibition of high-amplitude swelling at its different stages by means of rotenone +Mg2+ + trifluoromethoxyphenylhydrasonecarbonylcyanide (FCCP) addition. |
93(0,3,3,3) | Details |
| 9989245 | Cassarino DS, Parks JK, Parker WD Jr, Bennett JP Jr: The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta. 1999 Jan 6;1453(1):49-62. Rotenone, a classic non-competitive complex I inhibitor, completely inhibited MPP (+)-induced swelling and release of cytochrome c. |
85(1,1,1,5) | Details |
| 444478 | Lichtor T, Tung B, Getz GS: Cytoplasmically inherited respiratory deficiency of a mouse fibroblast line which is resistant to rutamycin. Biochemistry. 1979 Jun 12;18(12):2582-90. Levels of rotenone-sensitive -cytochrome c reductase and decarboxylase of the pyruvate dehydrogenase complex are markedly depressed in the mutant cells. |
31(0,1,1,1) | Details |
| 12177198 | Sherer TB, Betarbet R, Stout AK, Lund S, Baptista M, Panov AV, Cookson MR, Greenamyre JT: An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J Neurosci. 2002 Aug 15;22(16):7006-15. In response to H2O2, there was cytochrome c release from mitochondria, caspase-3 activation, and apoptosis, all of which occurred earlier and to a much greater extent in rotenone-treated cells; caspase inhibition provided substantial protection. |
31(0,1,1,1) | Details |
| 4172100 | Hoppel C, Cooper C: The action of digitonin on rat liver mitochondria. Biochem J. 1968 Apr;107(3):367-75. Almost all the -cytochrome c reductase (rotenone-insensitive) is lost whereas the major portions of the soluble and bound enzymes are retained. |
31(0,1,1,1) | Details |
| 7391131 | Borgese N, Meldolesi J: Localization and biosynthesis of NADH-cytochrome b5 reductase, an integral membrane protein, in rat liver cells. J Cell Biol. 1980 Jun;85(3):501-15. In fresh heavy and light Golgi fractions (GF3 and GF1 + 2) and in mitochondria, the specific activity of rotenone-insensitive -cytochrome c reductase was approximately 100, 60, and 30%, respectively, of the value found in microsomes. |
8(0,0,1,3) | Details |
| 19278021 | Song C, Scharf ME: Mitochondrial impacts of insecticidal esters in insecticide-resistant and insecticide-susceptible Drosophila melanogaster. Pest Manag Sci. 2009 Jun;65(6):697-703. and three positive control treatments (rotenone, antimycin A and induced cytochrome c release, verifying that is capable of causing mitochondrial disruption. |
8(0,0,1,3) | Details |
| 753379 | Comte J, Gautheron DC: The markers of pig heart mitochondrial sub-fractions. Biochimie. 1978;60(11-12):1298-1305. High ionic strength treatments by either NaCl- or 3M KCl have a strong effect, but they also remove cytochrome c oxidase and rotenone-sensitive -cytochrome c reductase, reputed inner membrane intrinsic enzymes, thus strongly damaging the inner membrane. |
6(0,0,1,1) | Details |
| 10908611 | Luetjens CM, Bui NT, Sengpiel B, Munstermann G, Poppe M, Krohn AJ, Bauerbach E, Krieglstein J, Prehn JH: Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in production. J Neurosci. 2000 Aug 1;20(15):5715-23. The secondary rise could be inhibited by the complex I inhibitor rotenone (in combination with oligomycin) and mimicked by the complex III inhibitor antimycin A. |
5(0,0,0,5) | Details |
| 16540393 | Chen Q, Lesnefsky EJ: Depletion of and cytochrome c during ischemia increases peroxide production from the electron transport chain. Free Radic Biol Med. 2006 Mar 15;40(6):976-82. Epub 2005 Nov 8. |
5(0,0,0,5) | Details |
| 10816428 | Doran E, Halestrap AP: Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: possible role of contact sites. Biochem J. 2000 Jun 1;348 Pt 2:343-50. Dextran also inhibited both mitochondrial oxidation of exogenous ferrocytochrome c in the presence of rotenone and antimycin, and respiratory-chain-driven reduction of exogenous ferricytochrome c. |
5(0,0,0,5) | Details |
| 18385062 | He Y, Leung KW, Zhang YH, Duan S, Zhong XF, Jiang RZ, Peng Z, Tombran-Tink J, Ge J: Mitochondrial complex I defect induces ROS release and degeneration in trabecular meshwork cells of POAG patients: protection by antioxidants. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1447-58. Primary TM cultures were treated with one of the following mitochondrial respiratory chain inhibitors: rotenone (ROT, complex I inhibitor), thenoyltrifluoroacetone (TTFA, complex II inhibitor), myxothiazol or antimycin A (MYX, AM-complex III inhibitors); mitochondrial permeability transition (MPT) inhibitor cyclosporine A (CsA); and antioxidants vitamin E (Vit E) or N-acetylcysteine (NAC). ROT induces a further increase in ROS production, the release of cytochrome c, and decreases in ATP level and Delta Psi m in GTM cells, eventually leading to apoptosis. |
2(0,0,0,2) | Details |
| 10408245 | Kunimoto S, Nosaka C, Takeuchi T: Stimulation of cellular XTT reduction by cytochrome oxidase inhibitors. . Biol Pharm Bull. 1999 Jun;22(6):660-1. Among the other respiratory chain inhibitors, antimycin A (a complex III inhibitor) and chlorpromazine inhibited cellular XTT reduction, and rotenone and showed slight inhibition and no effect, respectively. It is suggested that XTT reduction is coupled with the respiratory chain via cytochrome c, which is located between complexes III and IV (cytochrome oxidase). |
1(0,0,0,1) | Details |
| 2997133 | McEwan AG, Greenfield AJ, Wetzstein HG, Jackson JB, Ferguson SJ: Nitrous oxide reduction by members of the family Rhodospirillaceae and the nitrous oxide reductase of Rhodopseudomonas capsulata. J Bacteriol. 1985 Nov;164(2):823-30. Electron flow to nitrous oxide reductase was coupled to generation of a membrane potential and inhibited by rotenone but not antimycin. This pathway of electron transport could include cytochrome c', a component hitherto without a recognized function. |
1(0,0,0,1) | Details |
| 494532 | Kamysheva AS, Pigareva ZD: [Mitochondrial energy processes of the visual system in the rabbit brain normally and under conditions of light deprivation]. Vopr Med Khim. 1979 Sep-Oct;25(5):515-20. The mitochondria of experimental rabbits were characterized by distinct alteration in oxidative phosphorylation of glutamic acid, by an increased rate of electron transport at the step between cytochrome c-cytochrome oxidase-succinate dehydrogenase of the respiratory chain as well as by the peculiar effect of rothenone and DNP on the chain. |
1(0,0,0,1) | Details |
| 8897462 | Whatley SA, Curti D, Marchbanks RM: Mitochondrial involvement in schizophrenia and other functional psychoses. . Neurochem Res. 1996 Sep;21(9):995-1004. Studies on -cytochrome c reductase showed that schizophrenics whether medicated or not had a reduced rotenone sensitive activity that was compensated for by increased rotenone insensitive activity. |
0(0,0,0,0) | Details |
| 40546 | Lorusso M, Capuano F, Boffoli D, Stefanelli R, Papa S: The mechanism of transmembrane delta muH+ generation in mitochondria by cytochrome c oxidase. Biochem J. 1979 Jul 15;182(1):133-47. It is shown that re-reduction of formed ferricyanide and release derive from rotenone- and antimycin-resistant oxidation of endogenous reductants through the -translocating segments of the respiratory chain on the substrate side of cytochrome c. |
83(1,1,1,3) | Details |
| 18705696 | Liu WH, Chang LS: Reactive species and p38 mitogen-activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin gamma. J Cell Mol Med. 2008 Aug 14. Inhibitors of electron transport (rotenone and antimycin A) or inhibitor of mitochondrial permeability transition pore (cyclosporine A) reduced the effect of toxin gamma on ROS generation, loss of DeltaPsim and cytochrome c release. |
82(1,1,1,2) | Details |
| 2344448 | Wojtczak L, Baranska J, Zborowski J: Transport of within the mitochondrion. . Biochim Biophys Acta. 1990 May 22;1044(2):284-7. Transfer of from the outer to the inner membrane within intact rat liver mitochondria was assessed by measuring the ratio of lipid 32P to the marker enzyme of the outer membrane, rotenone-insensitive -cytochrome c reductase, in the outer and inner membrane fractions obtained after incubation of mitochondria under conditions for net synthesis of [32P] |
31(0,1,1,1) | Details |
| 17084831 | Shinde SB, Save VC, Patil ND, Mishra KP, Tendolkar AG: Impairment of mitochondrial respiratory chain enzyme activities in tetralogy of Fallot. Clin Chim Acta. 2007 Feb;377(1-2):138-43. Epub 2006 Sep 26. The activities of rotenone-sensitive cytochrome c reductase (complexes I+III), cytochrome c oxidase (complex IV) and the ratio of I and III to II and III complexes (complex I) were significantly lower in TOF (p <0.001). |
31(0,1,1,1) | Details |
| 15347666 | Lesnefsky EJ, Chen Q, Moghaddas S, Hassan MO, Tandler B, Hoppel CL: Blockade of electron transport during ischemia protects cardiac mitochondria. J Biol Chem. 2004 Nov 12;279(46):47961-7. Epub 2004 Sep 3. Rotenone pretreatment preserved the contents of and cytochrome c measured after 45 min of ischemia. |
8(0,0,1,3) | Details |
| 6093033 | Papadimitriou A, Neustein HB, Dimauro S, Stanton R, Bresolin N: Histiocytoid cardiomyopathy of infancy: deficiency of reducible cytochrome b in heart mitochondria. Pediatr Res. 1984 Oct;18(10):1023-8. Biochemical studies showed markedly decreased -cytochrome c reductase and rotenone-sensitive -cytochrome c reductase activities, while other mitochondrial enzymes were normal. |
7(0,0,1,2) | Details |
| 3736127 | Gorgani MN, Pour-Rahimi F, Meisami E: Arrhenius plots of membrane-bound enzymes of mitochondria and microsomes in the brain cortex of developing and old rats. Mech Ageing Dev. 1986 Jun;35(1):1-15. The enzymes were, dehydrogenase (BDH) for the inner mitochondrial membrane and rotenone-insensitive--cytochrome c reductase (Mit--CytR) for the outer membrane; also antimycin-insensitive--cytochrome c reductase (Micr--CytR) and -cytochrome c reductase for the microsomal membranes. |
7(0,0,1,2) | Details |
| 5563754 | Okamoto H: Influence of on kynurenine 3-hydroxylase, monoamine oxidase, and rotenone-insensitive -cytochrome c reductase in mitochondrial outer membrane. Biochem Biophys Res Commun. 1971 May 21;43(4):827-33. |
6(0,0,1,1) | Details |
| 2549583 | Elmore MA, O'Cuinn G: Localisation of a particulate luliberin hydrolysing activity in microsomal membranes of guinea pig brain. Regul Pept. 1989 Jun-Jul;25(3):343-52. Examination of subcellular fractions generated under different conditions indicated that particulate luliberin hydrolysing activity was most closely associated with the microsomal marker, rotenone-insensitive cytochrome C reductase. |
6(0,0,1,1) | Details |
| 12761579 | Gottlieb E, Armour SM, Harris MH, Thompson CB: Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ. 2003 Jun;10(6):709-17. |
5(0,0,0,5) | Details |
| 9762923 | Bodrova ME, Dedukhova VI, Mokhova EN, Skulachev VP: Membrane potential generation coupled to oxidation of external in liver mitochondria. FEBS Lett. 1998 Sep 18;435(2-3):269-74. It is found that exogenous when oxidized by rat liver mitochondria in hypotonic medium supplemented with Mg2+ and EGTA, generates a membrane potential (delta psi) even in the absence of added cytochrome c. Rotenone and myxothiazol do not inhibit delta psi generated by oxidation of exogenous |
4(0,0,0,4) | Details |
| 15958286 | del Arenal IP, Rubio ME, Ramirez J, Rendon JL, Escamilla JE: -resistant respiration in Taenia crassiceps metacestode (cysticerci) is explained by the H2O2-producing side-reaction of respiratory complex I with O2. Parasitol Int. 2005 Sep;54(3):185-93. Mitochondrial respiration with as substrate was partially inhibited by rotenone, and antimycin in decreasing order of effectiveness. Horse cytochrome c increased 2-3 times the rate of electron flow across the -sensitive pathway and the contribution of the -resistant route became negligible. |
2(0,0,0,2) | Details |
| 11299330 | Almeida A, Bolanos JP: A transient inhibition of mitochondrial ATP synthesis by synthase activation triggered apoptosis in primary cortical neurons. J Neurochem. 2001 Apr;77(2):676-90. Twenty-four hours after treatment, ATP was depleted, a phenomenon associated with a persistent inhibition of mitochondrial -cytochrome c reductase activity and delayed necrosis. |
1(0,0,0,1) | Details |
| 8720174 | Santhamma KR, Bhaduri A: Characterization of the respiratory chain of Leishmania donovani promastigotes. Mol Biochem Parasitol. 1995 Dec;75(1):43-53. Inhibition analysis of respiration of Leishmania donovani promastigotes in resting, starved and permeabilized cells in the presence of classical electron transfer complex inhibitors such as rotenone, thenoyltrifluoroacetone and antimycin demonstrated the absence of complex I component of the respiratory chain in this organism. A differential route for oxidation was further confirmed by cytochrome c reductase insensitivity to antimycin. |
1(0,0,0,1) | Details |
| 2115919 | Berthier JP, Raynal E, Kimel S, Avrillier S, Ollivier JP: XeCl laser action at medium fluences on biological tissues: fluorescence study and simulation with a chemical solution. J Photochem Photobiol B. 1990 May;5(3-4):495-503. Buffered solutions of cytochrome c and FAD, which play a role in the respiratory chain, were irradiated in order to simulate the in vivo findings. |
1(0,0,0,1) | Details |
| 412525 | Remennikov VG, Samuilov VD: [Light-induced uptake by chromatophores and subchromatophore pigment-protein complexes of Rhodospirillum rubrum]. Biokhimiia. 1977 Nov;42(11):1997-2004. Chromatophores of R. rubrum incubated with electron donors, e. g. reduced diaminodurene, TMPD, phenazine methosulphate, cytochrome c or ferrocyanide, are able to catalyze O2 uptake upon illumination. This process is inhibited by o-phenanthroline as well as upon extraction of quinones from chromatophores, but not by antimycin A, rotenone or CN-. |
1(0,0,0,1) | Details |
| 15485993 | Pignatelli M, Sanchez-Rodriguez J, Santos A, Perez-Castillo A: 15-deoxy-Delta-12,14- induces programmed cell death of breast cancer cells by a pleiotropic mechanism. Carcinogenesis. 2005 Jan;26(1):81-92. Epub 2004 Oct 14. In addition, 15dPG-J2 can also activate an intrinsic apoptotic pathway involving phosphatidyl serine externalization, caspase activation and cytochrome c release. In contrast, the addition of radical scavengers or rotenone, which prevent 15dPG-J2-induced ROS production, block the loss of cell viability induced by this prostaglandin. |
1(0,0,0,1) | Details |
| 12358746 | Starkov AA, Polster BM, Fiskum G: Regulation of peroxide production by brain mitochondria by and Bax. J Neurochem. 2002 Oct;83(1):220-8. In the presence of the respiratory chain Complex I inhibitor rotenone, accumulation of Ca2+ stimulated H2O2 production by mitochondria oxidizing and this stimulation was associated with release of mitochondrial cytochrome c. |
83(1,1,1,3) | Details |
| 2038500 | Fry M, Beesley JE: Mitochondria of mammalian Plasmodium spp. Parasitology. 1991 Feb;102 Pt 1:17-26. The -dependent reduction of cytochrome c was insensitive to rotenone and antimycin A. |
83(1,1,1,3) | Details |
| 7423051 | Weglicki WB, Kennett FF, Ruth RC: Lysosomal changes in an animal model of myocardial ischemia. Adv Myocardiol. 1980;2:371-81. It also permitted great enrichment of a membrane-bound enzyme localized to a microsomal fraction, rotenone-insensitive -cytochrome c reductase (RINCR). |
31(0,1,1,1) | Details |
| 15569251 | Gu M, Iravani MM, Cooper JM, King D, Jenner P, Schapira AH: Pramipexole protects against apoptotic cell death by non-dopaminergic mechanisms. J Neurochem. 2004 Dec;91(5):1075-81. However, pramipexole reduced caspase-3 activation, decreased the release of cytochrome c and prevented the fall in the mitochondrial membrane potential induced by MPP+ and rotenone. |
31(0,1,1,1) | Details |
| 8892026 | Pitkanen S, Feigenbaum A, Laframboise R, Robinson BH: NADH-coenzyme Q reductase (complex I) deficiency: heterogeneity in phenotype and biochemical findings. J Inherit Metab Dis. 1996;19(5):675-86. Each patient also had decreased rotenone-sensitive -cytochrome c reductase (complexes I and III) with normal cytochrome c reductase (complexes II and III) and cytochrome oxidase (complex IV) activity in cultured skin fibroblasts, indicating a deficient NADH-coenzyme Q reductase (complex I) activity. |
31(0,1,1,1) | Details |
| 1516736 | Szczesna-Kaczmarek A: Regulating effect of mitochondrial lactate dehydrogenase on oxidation of cytoplasmic via an "external" pathway in skeletal muscle mitochondria. Int J Biochem. 1992 Apr;24(4):657-61. The specific activity of mitochondrial LDH in skeletal muscle mitochondria was almost equal to the activity of rotenone-insensitive -cytochrome c reductase. 3. |
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| 2982320 | Okayasu T, Curtis MT, Farber JL: Structural alterations of the inner mitochondrial membrane in ischemic liver cell injury. Arch Biochem Biophys. 1985 Feb 1;236(2):638-45. With both preparations, the specific activity of rotenone-insensitive -cytochrome c reductase was 10-fold lower than in the mitochondria from which they were prepared. |
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| 612130 | Radeva-Domushieva D, Russanov E: Effect of single exhaustive swimming on mitochondrial enzyme activities in rat myocardium. Acta Physiol Pharmacol Bulg. 1977;3(3):49-55. The marker enzyme of the outer mitochondrial membranes--rotenone-insensitive NAD.H-cytochrome c-reductase--reveals unchanged activity after swimming and a 22-hour period of rest. |
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| 3009544 | Robinson BH, Ward J, Goodyer P, Baudet A: Respiratory chain defects in the mitochondria of cultured skin fibroblasts from three patients with lacticacidemia. J Clin Invest. 1986 May;77(5):1422-7. Measurement of Rotenone-sensitive -cytochrome c reductase in mitochondrial preparations from skin fibroblasts showed that two of the patients had 14 and 18%, respectively, of control activity. |
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| 147472 | Streumer-Svobodova Z, Drahota Z: The development of oxidative enzymes in rat liver mitochondria. . Physiol Bohemoslov. 1977;26(6):525-34. Rotenone-insensitive -cytochrome c reductase activity, which is localized on the outer mitochondrial membrane, remained stable up to the 10th day, and rose between the 10th and the 90th day. |
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| 1329742 | Huertas R, Campos Y, Diaz E, Esteban J, Vechietti L, Montanari G, D'Iddio S, Corsi M, Arenas J: Respiratory chain enzymes in muscle of endurance athletes: effect of Biochem Biophys Res Commun. 1992 Oct 15;188(1):102-7. Athletes receiving showed a significant increase (p < 0.01) in the activities of rotenone-sensitive cytochrome c reductase, cytochrome c reductase and cytochrome oxidase. |
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| 12180906 | Kushnareva Y, Murphy AN, Andreyev A: Complex I-mediated reactive species generation: modulation by cytochrome c and NAD (P)+ oxidation-reduction state. Biochem J. 2002 Dec 1;368(Pt 2):545-53. This increased ROS production can be mimicked by rotenone, a complex I inhibitor, as well as other chemical inhibitors of electron flow that act further downstream in the electron transport chain. |
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| 12473378 | Zhou G, Jiang W, Zhao Y, Ma G, Xin W, Yin J, Zhao B: tanshinone IIA sulfonate mediates electron transfer reaction in rat heart mitochondria. Biochem Pharmacol. 2003 Jan 1;65(1):51-7. It was found that STS could stimulate mitochondrial oxidation dose-dependently and partly restore oxidation in the presence of respiratory inhibitor (rotenone or antimycin A or KCN). The data also showed that cytochrome c (Cyt c) could be reduced by STS in the presence of KCN, or STS could transfer the electron to directly. |
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| 16024921 | Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP, Schnermann JB: Hypertonic induction of COX-2 in collecting duct cells by reactive species of mitochondrial origin. J Biol Chem. 2005 Oct 14;280(41):34966-73. Epub 2005 Jul 17. ROS levels, determined using dichlorodihydrofluorescence and cytochrome c, were rapidly and significantly increased following exposure of mIMCD-K2 cells to media made hypertonic by adding NaCl. The increases in ROSs in response to hypertonic treatment were completely blocked by any one of the mitochondrial inhibitors tested, such as rotenone, thenoyltrifluoroacetone, or carbonyl m-chlorophenylhydrazone, associated with remarkable inhibition of COX-2 expression. |
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| 15447660 | Akundi RS, Macho A, Munoz E, Lieb K, Bringmann G, Clement HW, Hull M, Fiebich BL: 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH. J Neurochem. 2004 Oct;91(2):263-73. In this study, we report that TaClo induces an apoptotic pathway in the human neuroblastoma cell line, SK-N-SH, involving the translocation of mitochondrial cytochrome c to the cytosol and activation of caspase 3. TaClo-induced apoptosis shows considerable differences from that mediated by other Parkinson-inducing agents such as MPTP, rotenone and |
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| 206463 | Moyle J, Mitchell P: Cytochrome c oxidase is not a proton pump. . FEBS Lett. 1978 Apr 15;88(2):268-72. We conclude that the reduction of O2 to 2 by cytochrome c oxidase of rat liver mitochondria involves the translocation of 4-from cytochrome c at the outer surface of the cristae membrane per O2 reduced and protonated by 4 H+ ions that enter the reaction domain from the inner aqueous phase. |
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| 16781454 | Kachadourian R, Day BJ: -induced depletion: potential implications for cancer treatment. Free Radic Biol Med. 2006 Jul 1;41(1):65-76. Epub 2006 Mar 31. Prototypic flavonoids (2',5'-DHC and chrysin) were subsequently tested for their abilities to potentiate the toxicities of prooxidants (etoposide, rotenone, and Assessments of mitochondrial GSH levels mitochondrial membrane potential and cytochrome c release showed that the potentiation effects induced by 2',5'-DHC and chrysin involve mitochondrial dysfunction. |
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| 9932647 | Sreeramulu K, Schmidt CL, Schafer G, Anemuller S: Studies of the electron transport chain of the euryarcheon Halobacterium salinarum: indications for a type II NADH dehydrogenase and a complex III analog. J Bioenerg Biomembr. 1998 Oct;30(5):443-53. The partially purified complex contained a Rieske iron- cluster, b- and c-type cytochromes, and was catalytically active in the decylubiquinone-cytochrome-c oxidoreductase assay. Complex I inhibitors like rotenone and annonine were inactive, clearly excluding the presence of a coupled NADH dehydrogenase. |
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| 11213482 | Somers MJ, Burchfield JS, Harrison DG: Evidence for a / oxidase in human umbilical vein endothelial cells using electron spin resonance. Antioxid Redox Signal. 2000 Winter;2(4):779-87. Rotenone (100 microM) did not significantly alter the signal intensity, (833 +/- 88). Prior studies have used indirect assessments of including lucigenin-enhanced chemiluminescence, cytochrome c, and fluorescent dye techniques. |
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| 14695307 | Joubert F, Fales HM, Wen H, Combs CA, Balaban RS: enzyme-dependent fluorescence recovery after photobleaching (ED-FRAP): applications to enzyme and mitochondrial reaction kinetics, in vitro. Biophys J. 2004 Jan;86(1 Pt 1):629-45. Evaluation of regeneration in active mitochondria, in comparison to rotenone-treated preparations, revealed other regulatory elements in addition to matrix and [NAD] that have yet to be fully characterized. The overall net reaction was O2 + 2NADH + 2H+ --> 2NAD+ + 2H2O, or in the presence of other competing electron acceptors such as cytochrome c, + 2Cyt (ox) --> NAD+ + H+ + 2Cyt (red). |
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| 6817820 | Clouet P, Henninger C, Bezard J: [Modes of action of a shortening system for at the mitochondrial level of rat liver]. Biochimie. 1982 Oct;64(10):899-906. In this work, were studied the conditions of (cis-docosenoic, n-9) shortening by using Rat liver mitochondrial preparations which were incubated in vitro with [14-14C] (22:1), with inhibitors of the respiratory chain (rotenone, or not, with activators of either the shortening reaction (NAD+, or beta-oxidation cytochrome c) or not. |
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| 7211067 | Halangk W, Bohnensack R, Kunz W: [Relation between intactness and nucleotide pattern of ejaculated bull spermatozoa]. Acta Biol Med Ger. 1980;39(7):791-808. This was oxygraphically measured in the presence of cytochrome c after inhibition of the cell respiration with rotenone. |
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| 16962987 | Lemeshko VV, Haridas V, Quijano Perez JC, Gutterman JU: Avicins, natural anticancer saponins, permeabilize mitochondrial membranes. Arch Biochem Biophys. 2006 Oct 15;454(2):114-22. Epub 2006 Aug 23. On the other hand, avicins increased the rotenone-insensitive oxidation of external in the presence of exogenous cytochrome c, long before high amplitude swelling of mitochondria was observed. |
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| 18832435 | Hu LF, Lu M, Wu ZY, Wong PT, Bian JS: inhibits rotenone-induced apoptosis via preservation of mitochondrial function. Mol Pharmacol. 2009 Jan;75(1):27-34. Epub 2008 Oct 2. NaHS also prevented rotenone-induced p38- and c-Jun NH (2)-terminal kinase (JNK)-mitogen-activated protein kinase (MAPK) phosphorylation and rotenone-mediated changes in Bcl-2/Bax levels, mitochondrial membrane potential (DeltaPsi (m)) dissipation, cytochrome c release, caspase-9/3 activation and poly (ADP- polymerase cleavage. |
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| 16659616 | Day DA, Rayner JR, Wiskich JT: Characteristics of External Oxidation by Beetroot Mitochondria. . Plant Physiol. 1976 Jul;58(1):38-42. These mitochondria have a rotenone- and antimycin-insensitive pathway of oxidation associated with the outer membrane and are capable of reducing cytochrome c or ferricyanide. |
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| 10876012 | Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J: Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta. 2000 Aug;298(1-2):157-73. In this paper, we present a complex protocol for evaluation of the function of mitochondrial OXPHOS enzymes in cultured amniocytes using three independent and complementary methods: (a) spectrophotometry as a tool for determination of the capacities of mitochondrial respiratory-chain enzymes (NADH ubiquinone oxidoreductase, - and glycerophosphate cytochrome c reductase, cytochrome c oxidase and citrate synthase); (b) polarography as a tool for the evaluation of mitochondrial OXPHOS enzyme functions in situ using digitonin-permeabilised amniocytes (rotenone-sensitive oxidation of pyruvate+malate, antimycin A-sensitive oxidation of KCN-sensitive oxidation of cytochrome c, -activated substrate oxidation) and (c) cytofluorometric determination of tetramethyl rhodamine methyl ester (TMRM) fluorescence in digitonin-permeabilised amniocytes as a sensitive way to determine the mitochondrial membrane potential under steady-state conditions (state 4 with |
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| 39598 | Krab K, Wikstrom M: On the stoichiometry and thermodynamics of -pumping cytochrome c oxidase in mitochondria. Biochim Biophys Acta. 1979 Oct 10;548(1):1-15. Similar results are obtained with either ferrocyanide, N.N.N',N'-tetramethyl-p-phenylenediamine or externally added cytochrome c mediating between and cytochrome c in rotenone- and antimycin-inhibited mitochondria. |
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