| 2115919 |
Berthier JP, Raynal E, Kimel S, Avrillier S, Ollivier JP: XeCl laser action at medium fluences on biological tissues: fluorescence study and simulation with a chemical solution. J Photochem Photobiol B. 1990 May;5(3-4):495-503.
A rat heart, isolated and perfused, was irradiated with a XeCl excimer laser at 308 nm. The evolution of the fluorescence spectrum was measured. For an incident energy E greater than 4 kJ m-2 per pulse the fluorescence changed with time in a complex and spectrally non-uniform way. The proposed interpretation is that the radiation acts on the cellular respiratory chain. Buffered solutions of NADH, cytochrome c and FAD, which play a role in the respiratory chain, were irradiated in order to simulate the in vivo findings. The conclusion of this study is that XeCl radiation introduces a modification in the functioning of the respiratory chain: it accelerates electron transfer, but this quickly leads to an interruption of the respiratory chain. |
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