Protein Information

Name fumarase
Synonyms FH; MCL; Fumarase; Fumarate hydratase; HLRCC; LRCC; MCUL 1; MCUL1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
10425713 Obungu VH, Kiaira JK, Njogu RM, Olembo NK: Catabolism of proline by procyclic culture forms of Trypanosoma congolense. Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):59-65.

Rotenone had no effect on the rate of respiration except when the intact cells were first permeabilized by digitonin after which rotenone decreased the rate of respiration by 20-30%.
Enzymes involved in the catabolism of proline with high activities were: proline dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, fumarase, NADP-linked malic enzyme, alanine aminotransferase and malate dehydrogenase.
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22598 Della Corte L, Callingham BA: The influence of adrenalectomy on monoamine oxidase and NADH cytochrome c reductase in the rat heart. J Pharm Pharmacol. 1977 Nov;29(11):657-63.

The effect of adrenalectomy on the activities of monoamine oxidase (MAO), NADH cytochrome c reductase (NCR), succinate dehydrogenase, malate dehydrogenase, fumarase, NAD+ nucleosidase and acid phosphatase in homogenates of rat hearts was examined.
However, both the total and the rotenone-insensitive NCR activities increased, with that of the rotenone-insensitive being about half of the total, which indicated that the effect of adrenalectomy was exerted on components of this enzyme localized on both the inner and outer membranes of the mitochondrion.
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1752630 Sambasivarao D, Sitaramam V: Characterization of mitochondrial membrane fragments resulting from spontaneous swelling: novel stimulation of NADH-dependent respiration by carboxylic acids. Indian J Biochem Biophys. 1991 Aug;28(4):280-90.

Metabolically induced high amplitude swelling of rat liver mitochondria has been found to result in the formation of a heterogeneous population of mitochondrial membranes consisting of right side-out particles with occluded fumarase activity and inside-out particles/fragments capable of NADH-dependent respiration.
This rotenone-sensitive, uncoupler-insensitive, NADH-dependent respiration was specifically and instantaneously stimulated by several ligands such as glutamate and malate (which can be metabolized) and, interestingly, even lactate (which could not be metabolized by the swollen mitochondria).
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