| Name | endothelin 1 |
|---|---|
| Synonyms | EDN 1; EDN1; ET1; Endothelin 1; Endothelin 1 precursor; PPET 1; PPET1; Preproendothelin 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11728422 | Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y: Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. Eur J Pharmacol. 2001 Nov 16;431(2):163-70. Primary cultured cardiomyocytes from neonatal rats were pretreated with rotenone, a mitochondrial complex I inhibitor, and the cytotoxic effect of endothelin-1 on the cardiomyocytes was demonstrated. |
123(1,2,3,8) | Details |
| 11078378 | Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I: Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S205-8. Therefore, in order to elucidate this problem, we developed an in vitro model of mitochondrial dysfunction using rotenone, a mitochondrial respiratory chain complex I inhibitor, and studied preproendothelin-1 gene expression and apoptosis. |
84(1,1,1,4) | Details |
| 11707688 | Yuhki KI, Miyauchi T, Kakinuma Y, Murakoshi N, Maeda S, Goto K, Yamaguchi I, Suzuki T: Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes. J Cardiovasc Pharmacol. 2001 Dec;38(6):850-8. |
81(1,1,1,1) | Details |
| 12821678 | Hua H, Munk S, Goldberg H, Fantus IG, Whiteside CI: High glucose-suppressed endothelin-1 Ca2+ signaling via oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells. J Biol Chem. 2003 Sep 5;278(36):33951-62. Epub 2003 Jun 23. Pretreatment with carbonyl m-chlorophenylhydrazone or rotenone did not restore Ca2+ signaling in HG. |
2(0,0,0,2) | Details |
| 19576886 | Matsuo J, Oku H, Kanbara Y, Kobayashi T, Sugiyama T, Ikeda T: Involvement of oxidase and protein kinase C in endothelin-1-induced production in retinal microvessels. Exp Eye Res. 2009 Nov;89(5):693-9. Epub 2009 Jul 2. In addition, the changes induced by adding apocynin (10 microM), myr-PKC (1.0 microM), allopurinol (100 microM), rotenone (10 microM), or L-NAME (100 microM) with ET-1 were evaluated. |
2(0,0,0,2) | Details |
| 11078377 | Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I: Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S201-4. In this study, we applied mitochondrial inhibitors, such as rotenone, and antimycin A, which inhibit mitochondrial function at different sites of the mitochondrial respiratory chain, to cardiomyocytes. |
1(0,0,0,1) | Details |
| 18801963 | Garciarena CD, Caldiz CI, Correa MV, Schinella GR, Mosca SM, Chiappe de Cingolani GE, Cingolani HE, Ennis IL: Na+/H+ exchanger-1 inhibitors decrease myocardial production via direct mitochondrial action. J Appl Physiol. 2008 Dec;105(6):1706-13. Epub 2008 Sep 18. Angiotensin II and endothelin-1 induced an oxidase (NOX)-dependent increase in anion (O (2)(-)) production detected by chemiluminescence. The mitochondria appeared to be the source of the NOX-dependent ROS released by the "ROS-induced ROS release mechanism" that was blunted by the mitochondrial ATP-sensitive potassium channel blockers 5-hydroxydecanoate and glibenclamide, inhibition of complex I of the electron transport chain with rotenone, and inhibition of the permeability transition pore (MPTP) by cyclosporin A. |
1(0,0,0,1) | Details |