| Name | microtubule associated proteins |
|---|---|
| Synonyms | GOLSYN; Golgi localized syntaphilin related protein; Golgi localized syntaphilin related proten A; Golgi localized syntaphilin related proten B; Golgi localized syntaphilin related proten C; Microtubule associated protein; SYBU; Syntabulin… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 568944 | Marshall LE, Himes RH: Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta. 1978 Nov 1;543(4):590-4. Rotenone effectively inhibits the in vitro formation of microtubules from tubulin containing or lacking microtubule-associated proteins. |
81(1,1,1,1) | Details |
| 16887804 | Jiang Q, Yan Z, Feng J: Neurotrophic factors stabilize microtubules and protect against rotenone toxicity on dopaminergic neurons. J Biol Chem. 2006 Sep 29;281(39):29391-400. Epub 2006 Aug 3. Thus, our results suggest that neurotrophic factors activate the microtubule-associated protein kinase pathway to stabilize microtubules, and this action significantly attenuates rotenone toxicity on dopaminergic neurons. |
32(0,1,1,2) | Details |
| 19074146 | Ren Y, Jiang H, Yang F, Nakaso K, Feng J: Parkin protects dopaminergic neurons against microtubule-depolymerizing toxins by attenuating microtubule-associated protein kinase activation. J Biol Chem. 2009 Feb 6;284(6):4009-17. Epub 2008 Dec 11. Such mutations produced truncated parkin proteins lacking any microtubule binding domain and prevented parkin from protecting midbrain dopaminergic neurons against microtubule-depolymerizing toxins such as rotenone or colchicine. |
2(0,0,0,2) | Details |
| 12716939 | Ren Y, Zhao J, Feng J: Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. J Neurosci. 2003 Apr 15;23(8):3316-24. Taken together, our results show that parkin is a novel tubulin-binding protein, as well as a microtubule-associated protein. In addition to inhibiting the mitochondrial respiratory chain, toxins known to cause Parkinson's disease (PD), such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and rotenone, also strongly depolymerize microtubules and increase tubulin degradation. |
1(0,0,0,1) | Details |
| 19900533 | Ishido M, Suzuki J: Inhibition by rotenone of mesencephalic neural stem-cell migration in a neurosphere assay in vitro. Toxicol In Vitro. 2010 Mar;24(2):552-7. Epub 2009 Nov 10. The migrating populations comprised cells that were positive for nestin, microtubule-associated proteins, and glial fibrillary acidic protein. |
1(0,0,0,1) | Details |
| 16624952 | Jiang Q, Yan Z, Feng J: Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006 Apr 19;26(16):4318-28. |
0(0,0,0,0) | Details |