Protein Information

Name cholecystokinin
Synonyms CCK; Cholecystokinin; Cholecystokinin preproprotein; Cholecystokinins; Cholecystokinins precursor; Procholecystokinin; Cholecystokinin preproproteins; Cholecystokinins precursors…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
11841804 Camello-Almaraz C, Salido GM, Pariente JA, Camello PJ: Role of mitochondria in Ca (2+) oscillations and shape of Ca (2+) signals in pancreatic acinar cells. Biochem Pharmacol. 2002 Jan 15;63(2):283-92.

Spreading of Ca (2+) waves evoked by the pancreatic secretagogue cholecystokinin cholecystokinin octapeptide was accelerated by mitochondrial inhibitors, whereas the cytosolic Ca (2+) concentration ([Ca (2+)](i)) oscillations in response to physiological levels of this hormone were suppressed by rotenone and carbonylcyanide-p-tryfluoromethoxyphenyl hydrazone.
32(0,1,1,2) Details
14499347 Gonzalez A, Granados MP, Salido GM, Pariente JA: Changes in mitochondrial activity evoked by cholecystokinin in isolated mouse pancreatic acinar cells. Cell Signal. 2003 Nov;15(11):1039-48.

Similar results were obtained when the cells were incubated in the presence of rotenone, which blocks the mitochondrial electron transport chain.
5(0,0,0,5) Details
16206242 Camello-Almaraz MC, Pozo MJ, Murphy MP, Camello PJ: Mitochondrial production of oxidants is necessary for physiological calcium oscillations. J Cell Physiol. 2006 Feb;206(2):487-94.


Mitochondria-targeted antioxidants and mitochondrial inhibitors quickly inhibited calcium oscillations in pancreatic acinar cells stimulated by postprandial levels of the gut hormone cholecystokinin.
2(0,0,0,2) Details
6099219 Norris SH, Hersey SJ: Inhibition of pepsinogen secretion in isolated gastric glands by amphotericin B is secretagogue specific. Can J Physiol Pharmacol. 1984 Dec;62(12):1518-24.

Pepsinogen secretion from isolated gastric glands, stimulated by 8-bromoadenosine 3',5'-cyclic monophosphate (8BrcAMP), forskolin, or cholecystokinin octapeptide, was inhibited by the presence of amphotericin B in the incubation medium.
Incubation of glands with either of the mitochondrial inhibitors, rotenone or carbonyl cyanide m-chlorophenylhydrazone, reduced pepsinogen secretory responses both to 8BrcAMP and to crude secretin.
1(0,0,0,1) Details
3876033 Norris SH, Hersey SJ: Stimulation of pepsinogen secretion in permeable isolated gastric glands. Am J Physiol. 1985 Sep;249(3 Pt 1):G408-15.


Pepsinogen secretion was elicited from digitonin-treated gastric glands by a number of agents, including calcium, vanadate, cholecystokinin octapeptide (CCK-OP), 8-bromo-adenosine 3',5'-cyclic monophosphate, and forskolin.
1(0,0,0,1) Details