| Name | DRP1 |
|---|---|
| Synonyms | DLP 1; DLP1; DRP1; DNM1L; DVLP; DYMPLE; Dnm1p/Vps1p like protein; Dynamin 1 like… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19492085 | Sandebring A, Thomas KJ, Beilina A, van der Brug M, Cleland MM, Ahmad R, Miller DW, Zambrano I, Cowburn RF, Behbahani H, Cedazo-Minguez A, Cookson MR: Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS One. 2009 May 27;4(5):e5701. We also show that wild-type PINK1, but not recessive mutant or kinase dead versions, protects against rotenone-induced mitochondrial fragmentation whereas PINK1 deficient cells show lower mitochondrial connectivity. |
2(0,0,0,2) | Details |
| 17298981 | Benard G, Bellance N, James D, Parrone P, Fernandez H, Letellier T, Rossignol R: Mitochondrial bioenergetics and structural network organization. J Cell Sci. 2007 Mar 1;120(Pt 5):838-48. Epub 2007 Feb 13. First, we determined the effect of mitochondrial fission on energy production by using small interfering RNA (siRNA) targeting DRP1, which revealed the importance of membrane fluidity on the control of bioenergetics. Second, we followed the effect of rotenone, a specific inhibitor of respiratory chain complex I, which causes large structural perturbations, once a threshold was reached. |
1(0,0,0,1) | Details |
| 18940801 | Dagda RK, Merrill RA, Cribbs JT, Chen Y, Hell JW, Usachev YM, Strack S: The spinocerebellar ataxia 12 gene product and protein phosphatase 2A regulatory subunit Bbeta2 antagonizes neuronal survival by promoting mitochondrial fission. J Biol Chem. 2008 Dec 26;283(52):36241-8. Epub 2008 Oct 21. Based on epistasis experiments involving Bcl2 and core components of the mitochondrial fission machinery (Fis1 and dynamin-related protein 1), mitochondrial fragmentation occurs upstream of apoptosis and is both necessary and sufficient for hippocampal neuron death. |
1(0,0,0,1) | Details |
| 16874299 | Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Graber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, Ellisman MH, Perkins GA, Bossy-Wetzel E: -induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J. 2006 Aug 23;25(16):3900-11. Epub 2006 Jul 27. Mitofusin 1 (Mfn1) or dominant-negative Dynamin related protein 1 (Drp1 (K38A)) inhibits mitochondrial fission induced by NO, rotenone and Amyloid-beta peptide. |
0(0,0,0,0) | Details |