Protein Information

Name Kir6.1
Synonyms ATP sensitive inward rectifier potassium channel 8; Inwardly rectifier K(+) channel Kir6.1; Inwardly rectifier K+ channel Kir6.1; Inwardly rectifying potassium channel Kir6.1; KCNJ 8; KCNJ8; KIR6.1; uKATP 1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
12603842 Tai KK, McCrossan ZA, Abbott GW: Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar;84(5):1193-200.

Using specific antibodies against SUR1 and Kir6.1, we detected immunoreactive proteins of apparent molecular masses 155 and 50 kDa, corresponding to those previously reported for SUR1 and Kir6.1, respectively, in the mitochondria-enriched fraction of PC12 cells.
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19012619 Zhou F, Yao HH, Wu JY, Ding JH, Sun T, Hu G: Opening of microglial K (ATP) channels inhibits rotenone-induced neuroinflammation. J Cell Mol Med. 2008 Sep-Oct;12(5A):1559-70.

The present study demonstrates that rat primary cultured MG expressed Kir6.1 and SUR2 subunits of K (ATP) channel, which was identical to that expressed in BV-2 microglial cell line.
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