| Name | p160 ROCK |
|---|---|
| Synonyms | NY REN 35 antigen; P160ROCK; ROCK 1; ROCK1; ROK alpha; ROKa; ROKalpha; Rho associated coiled coil containing protein kinase 1… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17353442 | Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thebaud B, Michelakis ED, Archer SL: activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive species: a newly recognized mechanism for sustaining ductal constriction. Circulation. 2007 Apr 3;115(13):1777-88. Epub 2007 Mar 12. Activation of Rho-kinase in DA smooth muscle cells is initiated by a PO2-dependent, rotenone-sensitive increase in mitochondrion-derived reactive O2 species. |
41(0,1,1,11) | Details |
| 18480073 | Sanchez M, Gastaldi L, Remedi M, Caceres A, Landa C: Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons. Toxicol Sci. 2008 Aug;104(2):352-61. Epub 2008 May 13. In accordance with this, treatment of neuronal cultures with cytochalasin D, an actin-depolymerizing drug, or with the Rho-kinase inhibitor Y27632, or overexpression of Tiam1, a nucleotide exchange factor for Rac, reverts the inhibitory effect of rotenone on axon formation. |
31(0,1,1,1) | Details |
| 15764673 | Bailey SR, Mitra S, Flavahan S, Flavahan NA: Reactive species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H243-50. Epub 2005 Mar 11. Cold causes translocation of alpha2C-ARs from the trans-Golgi to the plasma membrane, mediated by cold-induced activation of RhoA and Rho kinase. The inhibitor of mitochondrial complex I rotenone (10 micromol/l), the antioxidant (NAC; 20 mmol/l), or the cell-permeable mimic of superoxide dismutase MnTMPyP (50 micromol/l) did not affect vasoconstriction to alpha2-AR stimulation (UK-14304) at 37 degrees C but dramatically inhibited the response at 28 degrees C. |
2(0,0,0,2) | Details |
| 19747897 | Preta G, de Klark R, Glas R: A role for nuclear translocation of tripeptidyl-peptidase II in reactive species-dependent DNA damage responses. Biochem Biophys Res Commun. 2009 Nov 27;389(4):575-9. Epub 2009 Sep 10. Here we show that TPPII translocated into the nucleus in a p160-ROCK-dependent fashion in response to gamma-irradiation, and that nuclear expression of TPPII was present in most gamma-irradiated transformed cell lines. Further, this required cellular production of ROS; treatment with either N-acetyl- (anti-oxidant) or Rotenone (inhibitor of mitochondrial respiration) inhibited nuclear accumulation of TPPII. |
1(0,0,0,1) | Details |
| 18799631 | Greyner H, Dzialowski EM: Mechanisms mediating the -induced vasoreactivity of the ductus arteriosus in the chicken embryo. Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1647-59. Epub 2008 Sep 17. The O (2)-induced contraction is mediated by the Rho kinase pathway, as fasudil and Y-27632 significantly relax the O (2) contracted DA. As in the mammalian DA, inhibiting mitochondrion-derived reactive species production with rotenone and antimycin A relaxed the O (2)-constricted DA. |
1(0,0,0,1) | Details |
| 19855056 | Gao Q, Zhao X, Ahmad M, Wolin MS: Mitochondrial-derived peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2262-9. Epub 2009 Oct 23. Increasing mitochondrial with inhibitors of electron transport (10 microM rotenone and antimycin) and by opening mitochondrial ATP-dependent K+ channels with 100 microM diazoxide were observed in this study to attenuate relaxation of BCA precontracted with 30 mM KCl to hypoxia by 68-76% and 38%, respectively. |
0(0,0,0,0) | Details |