Protein Information

Name uncoupling protein 2
Synonyms Mitochondrial uncoupling protein 2; SLC25A8; UCP 2; UCP2; UCPH; UPCH; Uncoupling protein 2; Uncoupling protein 2s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
9647363 Paulik MA, Buckholz RG, Lancaster ME, Dallas WS, Hull-Ryde EA, Weiel JE, Lenhard JM: Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists. Pharm Res. 1998 Jun;15(6):944-9.

METHODS: Yeast were transformed with uncoupling protein-2 (UCP2) or exposed to carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) or rotenone.
8(0,0,1,3) Details
18082129 Giardina TM, Steer JH, Lo SZ, Joyce DA: Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages. Biochim Biophys Acta. 2008 Feb;1777(2):118-29. Epub 2007 Nov 22.

We observed that the abundance of UCP2 in macrophages increased rapidly in response to treatments (rotenone, antimycin A and diethyldithiocarbamate) that increased mitochondrial superoxide production, but not in response to superoxide produced outside the mitochondria or in response to H2O2.
6(0,0,0,6) Details