Protein Information

Name cyclin D1
Synonyms B cell CLL/lymphoma 1; B cell leukemia 1; BCL 1; BCL 1 oncogene; BCL1; CCND 1; CCND1; Cyclin D1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15897899 Felty Q, Singh KP, Roy D: Estrogen-induced G1/S transition of G0-arrested estrogen-dependent breast cancer cells is regulated by mitochondrial oxidant signaling. Oncogene. 2005 Jul 21;24(31):4883-93.

NAC or rotenone reduced E2-induced cyclin D1 expression.
162(2,2,2,2) Details
15863496 Taille C, El-Benna J, Lanone S, Boczkowski J, Motterlini R: Mitochondrial respiratory chain and NAD (P) H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J Biol Chem. 2005 Jul 8;280(27):25350-60. Epub 2005 Apr 29.

Because both diphenylene iodinium or apocynin (inhibitors of NAD (P) H oxidase) and rotenone (a molecule that increases mitochondrial ROS production by blocking the respiratory chain) mimicked the effect of CORM-2 on cyclin D1 expression and ASMC proliferation, the antiproliferative effect of CORM-2 is probably related to inhibition of cytochromes on both NAD (P) H oxidase and the respiratory chain.
83(1,1,1,3) Details
15960896 Liu HL, Chen Y, Cui GH, Wu QL, He J: Regulating expressions of cyclin D1, pRb, and anti-cancer effects of deguelin on human Burkitt's lymphoma Daudi cells in vitro. Acta Pharmacol Sin. 2005 Jul;26(7):873-80.

4(0,0,0,4) Details
17649631 Liu HL, Chen Y, Cui GH, Wu QL, Chen WH, He J: [Effect of deguelin on proliferation and apoptosis of lymphoma Daudi cells and its mechanism]. Zhonghua Zhong Liu Za Zhi. 2007 Mar;29(3):176-80.


The expressions of cyclin D1 and pRb were checked by Western blot.
3(0,0,0,3) Details
16412576 Chen MJ, Yap YW, Choy MS, Koh CH, Seet SJ, Duan W, Whiteman M, Cheung NS: Early induction of calpains in rotenone-mediated neuronal apoptosis. Neurosci Lett. 2006 Apr 10-17;397(1-2):69-73. Epub 2006 Jan 10.

0(0,0,0,0) Details