| Name | dihydroorotate dehydrogenase |
|---|---|
| Synonyms | DHODH; DHOdehase; Dihydroorotate dehydrogenase; Dihydroorotate oxidase; Human complement of yeast URA1; DHOdehases; Dihydroorotate dehydrogenases; Dihydroorotate oxidases… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15571245 | Gattermann N, Dadak M, Hofhaus G, Wulfert M, Berneburg M, Loeffler ML, Simmonds HA: Severe impairment of nucleotide synthesis through inhibition of mitochondrial respiration. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1275-9. This was surprising since Rotenone inhibits complex I of the respiratory chain, which is upstream of where DHODH interacts with the RC. |
32(0,1,1,2) | Details |
| 19747108 | Torrentino-Madamet M, Desplans J, Travaille C, James Y, Parzy D: Microaerophilic Respiratory Metabolism of Plasmodium falciparum Mitochondrion as a Drug Target. Curr Mol Med. 2009 Sep 13. We try to clarify the mitochondrial role in the intraerythrocytic environment and particularly focus on mitochondrial metabolic pathways that relate to oxidative phosphorylation, including the tricarboxylic acid cycle, de novo pyrimidine biosynthesis via dihydroorotate dehydrogenase and the particularities of the electron transport chain. In addition, we provide details on certain characteristics like the lack of pyruvate dehydrogenase, the existence of a rotenone-insensitive NADH-dehydrogenase, the possible existence of an alternative oxidase, and uncoupled proteins. |
1(0,0,0,1) | Details |
| 19097788 | Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF: Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1;19(3):972-5. Epub 2008 Nov 24. Plasmodium falciparum NDH2 (pfNDH2) is a non- pumping, rotenone-insensitive alternative enzyme to the multi-subunit NADH:ubiquinone oxidoreductases (Complex I) of many other eukaryotes. Here, we provide evidence that HDQ likely targets another P. falciparum mitochondrial enzyme, dihydroorotate dehydrogenase (pfDHOD), which is essential for de novo pyrimidine biosynthesis. |
1(0,0,0,1) | Details |
| 20205678 | Torrentino-Madamet M, Desplans J, Travaille C, James Y, Parzy D: Microaerophilic respiratory metabolism of Plasmodium falciparum mitochondrion as a drug target. Curr Mol Med. 2010 Feb 1;10(1):29-46. We try to clarify the mitochondrial role in the intraerythrocytic environment and particularly focus on mitochondrial metabolic pathways that relate to oxidative phosphorylation, including the tricarboxylic acid cycle, de novo pyrimidine biosynthesis via dihydroorotate dehydrogenase and the particularities of the electron transport chain. In addition, we provide details on certain characteristics like the lack of pyruvate dehydrogenase, the existence of a rotenone-insensitive NADH-dehydrogenase, the possible existence of an alternative oxidase, and uncoupled proteins. |
1(0,0,0,1) | Details |