| Name | caspase 9 |
|---|---|
| Synonyms | APAF 3; APAF3; Apoptotic protease MCH6; Apoptotic protease Mch 6; Apoptotic protease activating factor 3; CASP 9; CASP9; CASPASE 9c… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16207793 | Potokar M, Kreft M, Chowdhury HH, Vardjan N, Zorec R: Subcellular localization of Apaf-1 in apoptotic rat pituitary cells. Am J Physiol Cell Physiol. 2006 Mar;290(3):C672-7. Epub 2005 Oct 5. We show herein that 2 h after triggering apoptosis with rotenone, Apaf-1 redistributed to the proximity of mitochondria. In addition, the degree of colocalization between Apaf-1 and fluorescently labeled caspase-9 significantly increased during the same period. |
1(0,0,0,1) | Details |
| 18817777 | Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D: Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett. 2008 Oct 29;582(25-26):3601-6. Epub 2008 Sep 24. We noted that PM enhanced human CF bronchial epithelial apoptosis, activated caspase-9 and PARP-1; and reduced mitochondrial membrane potential. Mitochondrial inhibitors (4,4-diisothiocyanatostilbene-2,2'disulfonic acid, rotenone and thenoyltrifluoroacetone) blocked PM-induced generation of reactive species and apoptosis. |
1(0,0,0,1) | Details |
| 20226830 | Cuello S, Goya L, Madrid Y, Campuzano S, Pedrero M, Bravo L, Camara C, Ramos S: Molecular mechanisms of methylmercury-induced cell death in human HepG2 cells. Food Chem Toxicol. 2010 Mar 10. This feature was preceded by an enhancement in the caspase-9 activity (2h), whereas caspase-8 activity remained unchanged. |
1(0,0,0,1) | Details |
| 19885011 | Kim HJ, Song JY, Park HJ, Park HK, Yun DH, Chung JH: Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells. Korean J Physiol Pharmacol. 2009 Aug;13(4):281-5. Epub 2009 Aug 31. In addition, reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP- polymerase (PARP), and caspase 3. |
1(0,0,0,1) | Details |
| 18705696 | Liu WH, Chang LS: Reactive species and p38 mitogen-activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin gamma. J Cell Mol Med. 2008 Aug 14. Subsequent modulation of Bcl-2 family member and cytochrome c release accompanied with activation of caspase-9 and -3 were involved in the death of U937 cells. Inhibitors of electron transport (rotenone and antimycin A) or inhibitor of mitochondrial permeability transition pore (cyclosporine A) reduced the effect of toxin gamma on ROS generation, loss of DeltaPsim and cytochrome c release. |
1(0,0,0,1) | Details |
| 15805231 | Ghosh S, Pulinilkunnil T, Yuen G, Kewalramani G, An D, Qi D, Abrahani A, Rodrigues B: Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H768-76. Epub 2005 Apr 1. With the use of rotenone (an inhibitor of the electron transport chain) to decrease the excessive ROS in acute streptozotocin (STZ)-induced diabetic rat heart, the mitochondrial origin of ROS was established. Furthermore, mitochondrial damage, as evidenced by loss of membrane potential, increases in oxidative stress, and reduction in mGSH was associated with increased apoptosis via increases in caspase-9 and -3 activities in acutely diabetic hearts. |
1(0,0,0,1) | Details |
| 18402771 | Lee J, Huang MS, Yang IC, Lai TC, Wang JL, Pang VF, Hsiao M, Kuo MY: Essential roles of caspases and their upstream regulators in rotenone-induced apoptosis. Biochem Biophys Res Commun. 2008 Jun 20;371(1):33-8. Epub 2008 Apr 8. Western blotting showed activation of both the caspase-8 and caspase-9 pathways, which differed from previous studies conducted in other cell types. |
1(0,0,0,1) | Details |
| 18619991 | Chen KC, Lin SR, Chang LS: Involvement of mitochondrial alteration and reactive species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells. Toxicon. 2008 Aug 1;52(2):361-8. Epub 2008 Jun 24. The apoptosis signals of CTX3 included reactive species (ROS) generation, disruption of mitochondrial membrane potential (DeltaPsim), cytochrome c release to the cytosol and activation of caspase-9 and -3. Co-incubation with rotenone, an inhibitor of mitochondrial electron transport chain complexes I, resulted in partial inhibition of CTX3-induced ROS generation but not the loss of DeltaPsim. |
1(0,0,0,1) | Details |
| 20187293 | Liu WH, Chang LS: Reactive species and p38 mitogen-activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin-gamma. J Cell Mol Med. 2009 Aug;13(8B):1695-705. Subsequent modulation of Bcl-2 family member and cytochrome c release accompanied with activation of caspase-9 and -3 were involved in the death of U937 cells. Inhibitors of electron transport (rotenone and antimycin A) or inhibitor of mitochondrial permeability transition pore (cyclosporine A) reduced the effect of toxin- on ROS generation, loss of deltapsim and cytochrome c release. |
1(0,0,0,1) | Details |
| 12419464 | Choi DH, Kim DH, Park YG, Chun BG, Choi SH: Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes. Free Radic Biol Med. 2002 Nov 15;33(10):1321-33. Naphthazarin-induced cytotoxicity was evidenced by the ordered development of lysosomal acridine orange relocation, decrease in mitochondrial potential, cytochrome c release, and caspase-9 activation, and was inhibited by guanabenz, rilmenidine, and AGN 192403. Antimycin A and rotenone induced mitochondrial dysfunction primarily, and their cytotoxicities were inhibited only by AGN 192403. |
1(0,0,0,1) | Details |
| 19723537 | Park HJ, Kim HJ, Park HK, Chung JH: Protective effect of histamine H2 receptor antagonist against rotenone-induced apoptosis. Neurotoxicology. 2009 Nov;30(6):1114-9. Epub 2009 Aug 31. |
0(0,0,0,0) | Details |
| 19631247 | Liang JH, Du J, Xu LD, Jiang T, Hao S, Bi J, Jiang B: Catalpol protects primary cultured cortical neurons induced by Abeta (1-42) through a mitochondrial-dependent caspase pathway. Neurochem Int. 2009 Dec;55(8):741-6. Epub 2009 Jul 22. It has been reported that catalpol, an iridoid glucoside, isolated from the root of Rehmannia glutinosa, protected cells from damage induced by a variety of toxic stimulus such as LPS, MPP (+) and rotenone. |
0(0,0,0,0) | Details |
| 19850127 | Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG: VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiol Dis. 2010 Feb;37(2):330-8. Epub 2009 Oct 20. In SH-SY5Y neuroblastoma cell lines stably transfected with hVPS41, we determined that presence of this protein conferred protection against the neurotoxins 6-OHDA and rotenone. |
0(0,0,0,0) | Details |
| 20018182 | Li J, Xu Z, Tan M, Su W, Gong XG: 3-(4-(Benzo [d] thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) induced Hep G2 cell apoptosis through a ROS-mediated pathway. Chem Biol Interact. 2010 Feb 12;183(3):341-8. Epub 2009 Dec 16. Additionally, rotenone, an inhibitor of mitochondria electron transport system, effectively blocked the ROS elevated effect of DPB-5, which suggested that DPB-5-induced ROS generated from the mitochondria. |
0(0,0,0,0) | Details |
| 19539006 | Kim HJ, Park HJ, Park HK, Chung JH: Tranexamic acid protects against rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Toxicology. 2009 Aug 3;262(2):171-4. Epub 2009 Jun 16. |
0(0,0,0,0) | Details |
| 18832435 | Hu LF, Lu M, Wu ZY, Wong PT, Bian JS: inhibits rotenone-induced apoptosis via preservation of mitochondrial function. Mol Pharmacol. 2009 Jan;75(1):27-34. Epub 2008 Oct 2. NaHS also prevented rotenone-induced p38- and c-Jun NH (2)-terminal kinase (JNK)-mitogen-activated protein kinase (MAPK) phosphorylation and rotenone-mediated changes in Bcl-2/Bax levels, mitochondrial membrane potential (DeltaPsi (m)) dissipation, cytochrome c release, caspase-9/3 activation and poly (ADP- polymerase cleavage. |
81(1,1,1,1) | Details |
| 12782307 | Potokar M, Milisav I, Kreft M, Stenovec M, Zorec R: Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. FEBS Lett. 2003 Jun 5;544(1-3):153-9. The activation of apoptosis with rotenone triggers the redistribution of caspase-9 to mitochondria. |
86(1,1,1,6) | Details |
| 16917840 | Imamura K, Takeshima T, Kashiwaya Y, Nakaso K, Nakashima K: D- protects dopaminergic SH-SY5Y cells in a rotenone model of Parkinson's disease. J Neurosci Res. 2006 Nov 1;84(6):1376-84. Whereas rotenone caused the loss of mitochondrial membrane potential, released cytochrome c into the cytosol, and reduced cytochrome c content in mitochondria, addition of bHB blocked this toxic effect. bHB also attenuated the rotenone-induced activation of caspase-9 and caspase-3. |
81(1,1,1,1) | Details |
| 15280438 | Watabe M, Nakaki T: Rotenone induces apoptosis via activation of bad in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther. 2004 Dec;311(3):948-53. Epub 2004 Jul 27. Furthermore, the inhibition of caspase-9, which functions downstream from Bad, completely suppressed rotenone-induced apoptosis. |
31(0,1,1,1) | Details |
| 18242171 | Chen S, Zhang X, Yang D, Du Y, Li L, Li X, Ming M, Le W: D2/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways. FEBS Lett. 2008 Mar 5;582(5):603-10. Epub 2008 Jan 31. Furthermore, we demonstrated that ropinirole can reduce the rotenone-induced cleavages of caspase 9, caspase 3 and PARP and elevate the expression of anti-apoptotic proteins of p-Akt and bcl-2. |
31(0,1,1,1) | Details |
| 15659217 | Li J, Spletter ML, Johnson DA, Wright LS, Svendsen CN, Johnson JA: Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J Neurochem. 2005 Feb;92(3):462-76. |
8(0,0,1,3) | Details |
| 12730670 | Djavaheri-Mergny M, Wietzerbin J, Besancon F: induces apoptosis in Ewing sarcoma cells through mitochondrial peroxide production. Oncogene. 2003 May 1;22(17):2558-67. Here, we report that 2-methoxy- (2-Me), a natural metabolite, induced a caspase-dependent apoptosis of Ewing sarcoma-derived cells independently of their p53 status. 2-Me-induced apoptosis occurred through the mitochondrial death pathway as evidenced by reduction of the mitochondrial transmembrane potential, cytochrome c release and caspase-9 activation. Rotenone, an inhibitor of the mitochondrial respiratory chain, abolished both apoptosis and H (2) O (2) production, thereby identifying mitochondria as the source of H (2) O (2). |
3(0,0,0,3) | Details |
| 14580847 | Dutkowski P, Krug A, Krysiak M, Dunschede F, Seifert JK, Junginger T: Detection of mitochondrial electron chain carrier redox status by transhepatic light intensity during rat liver reperfusion. Cryobiology. 2003 Oct;47(2):125-42. Mitochondrial electron chain carriers were inhibited at different sites with rotenone and in some experiments. reversed transcriptional polymerase chain reaction (RT-PCR) was performed after reperfusion concerning transcription of TNFalpha, caspase 9, and c-jun kinase (JNK). Increased formation as well as transcription of TNFalpha, caspase 9, and JNK during reperfusion after cold storage (CS) were related with completely reduced cytochromes before and during reperfusion. |
2(0,0,0,2) | Details |
| 16157303 | Nutku E, Hudson SA, Bochner BS: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun. 2005 Oct 28;336(3):918-24. Siglec-8 crosslinking induced rapid cleavage of caspase-3, caspase-8, and caspase-9 in eosinophils. Rotenone and antimycin, inhibitors of mitochondrial respiratory chain components, completely inhibited apoptosis. |
2(0,0,0,2) | Details |
| 17102131 | Brown NM, Martin SM, Maurice N, Kuwana T, Knudson CM: Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells. J Biol Chem. 2007 Jan 26;282(4):2144-55. Epub 2006 Nov 13. Following interleukin (IL)-3 withdrawal in FL5.12 cells, Bax undergoes a conformational change that results in its mitochondria targeting, cytochrome c release, activation of caspase-9, and apoptosis. Furthermore, the "rescued" cells were resistant to rotenone, an inhibitor of mitochondrial respiration. |
2(0,0,0,2) | Details |
| 16990509 | Moungjaroen J, Nimmannit U, Callery PS, Wang L, Azad N, Lipipun V, Chanvorachote P, Rojanasakul Y: Reactive species mediate caspase activation and apoptosis induced by in human lung epithelial cancer cells through Bcl-2 down-regulation. J Pharmacol Exp Ther. 2006 Dec;319(3):1062-9. Epub 2006 Sep 21. Apoptosis induced by LA was found to be mediated through the mitochondrial death pathway, which requires caspase-9 activation. Likewise, the mitochondrial respiratory chain inhibitor rotenone potently inhibited the apoptotic and ROS-inducing effects of LA, supporting the role of mitochondrial ROS in LA-induced cell death. |
2(0,0,0,2) | Details |
| 17568818 | Geeraerts B, Vanhoecke B, Vanden Berghe W, Philippe J, Offner F, Deforce D: Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro. Leukemia. 2007 Aug;21(8):1610-8. Epub 2007 Jun 14. The induced apoptosis was characterized by processing of caspase-9 and -3 and poly-(ADP)--polymerase cleavage. |
1(0,0,0,1) | Details |