Protein Information

Name protein phosphatases
Synonyms DUSP17; DUSP19; Dual specificity phosphatase 19; Dual specificity protein phosphatase 19; Dual specificity phosphatase TS DSP1; LMW DSP3; Protein phosphatase; Protein phosphatase SKRP1…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15574738 Hongpaisan J, Winters CA, Andrews SB: Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons. J Neurosci. 2004 Dec 1;24(48):10878-87.


The common mechanism involves O2- inhibition of inactivating protein phosphatases.
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9744814 Loktionova SA, Kabakov AE: Protein phosphatase inhibitors and heat preconditioning prevent Hsp27 dephosphorylation, F-actin disruption and deterioration of morphology in ATP-depleted endothelial cells. FEBS Lett. 1998 Aug 21;433(3):294-300.

Endothelial cells (EC) cultured from human aorta or umbilical vein were incubated in a glucose-free medium containing CCCP or rotenone.
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