Protein Information

Name mMDH
Synonyms M MDH; MDH; MDH 2; MDH2; MOR1; Malate dehydrogenase; Malate dehydrogenase mitochondrial; mMDH…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19693701 Lu RH, Ji H, Chang ZG, Su SS, Yang GS: Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation. Mol Biol Rep. 2009 Aug 20.

The mRNA expression levels of mitochondrial gene including cytochromes c (Cyt c), malate dehydrogenases (MDH), and peroxisome proliferator activated receptor (PPAR) gamma coactivator-1beta (PGC-1beta) significantly increased along with the proceeding of adipocyte differentiation.
The damage to mitochondrial respiratory chain function by rotenone caused significant decrease in gene expressions including mitochondrial MDH and PGC-1beta, and PPARgamma, CAAT/enhancer binding protein alpha (C/EBPalpha) and sterol regulatory element binding protein-1c (SREBP-1c), which are known as transcription factors of differentiation, and differentiation marker gene named fatty acid synthetase.
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18403382 Hong HT, Nose A, Agarie S, Yoshida T: Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III. J Exp Bot. 2008;59(7):1819-27. Epub 2008 Apr 9.


The mitochondria showed high malate dehydrogenase (mMDH) and aspartate amino transferase (mAST), and a significant amount of malic enzyme (mME) activities.
3(0,0,0,3) Details
1722151 Rasmusson AG, Moller IM: Effect of calcium ions and inhibitors on internal NAD (P) H dehydrogenases in plant mitochondria. Eur J Biochem. 1991 Dec 5;202(2):617-23.


Bintje) tuber mitochondria and the rotenone-insensitive internal oxidation of NADPH by inside-out submitochondrial particles were dependent on Ca2+.
0(0,0,0,0) Details