| 10780954 |
Lin Z, Weinberg JM, Malhotra R, Merritt SE, Holzman LB, Brosius FC 3rd: GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. . Am J Physiol Endocrinol Metab. 2000 May;278(5):E958-66.
Similar protection against cell death and apoptosis was seen in GLUT-1-overexpressing cells treated for 6 h with the electron transport inhibitor rotenone.
A catalytically inactive mutant of MEKK1, an upstream kinase in the JNK pathway, reduced hypoxia-induced apoptosis by 39%. |
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