| 18466357 |
Castera L, Hatzfeld-Charbonnier AS, Ballot C, Charbonnel F, Dhuiege E, Velu T, Formstecher P, Mortier L, Marchetti P: Apoptosis-related mitochondrial dysfunction defines human monocyte-derived dendritic cells with impaired immuno-stimulatory capacities. J Cell Mol Med. 2009 Jul;13(7):1321-35. Epub 2008 May 3.
Importantly, pre-apoptotic DCs (characterized by a low Delta psi m) showed a modified phenotype, with down-regulation of HLA-DR and of the co-stimulatory molecules CD80 and CD86.
Perturbations to mitochondrial respiration with rotenone identified the same modifications to DC immune functions. |
1(0,0,0,1) |
Details |