| Name | glutaminase |
|---|---|
| Synonyms | GA; Phosphate activated glutaminase; glutaminase; GLS; GLS 2; GLS2; Glutaminase I; L glutamine amidohydrolase… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 708783 | Joseph SK, McGivan JD: The effect of ammonium and glucagon on the metabolism of in isolated liver cells from starved rats. Biochim Biophys Acta. 1978 Sep 21;543(1):16-28. It is suggested that both ammonium and glucagon exert their effects on metabolism by increasing the effective activity of mitochondrial glutaminase (EC 3.5.1.2.). The effective activation of hydrolysis by ammonimum in intact mitochondria was partially inhibited by rotenone and was abolished by uncoupling agents. 4. |
1(0,0,0,1) | Details |
| 1684269 | Osbakken M, Zhang DN, Nelson D, Erecinska M: Effect of cyclocreatine feeding on levels of amino acids in rat hearts before and after an ischemic episode. Am J Physiol. 1991 Dec;261(6 Pt 2):H1919-26. In the presence of rotenone and aminooxyacetate, heart homogenates catalyzed production of from which was markedly stimulated by Pi and inhibited by H+. It is postulated that 1) phosphate-activated glutaminase is an important enzyme that determines cardiac 2) lower in hearts from rats fed cyclocreatine is responsible for the apparently lesser activity of glutaminase, 3) breakdown of the high-energy compounds and consequent rise in Pi activates glutaminase, and 4) slow breakdown of during global ischemia is a result of inhibition of glutaminase by H+. |
1(0,0,0,1) | Details |
| 6487648 | Strzelecki T, Schoolwerth AC: The significance of the attachment of rat kidney glutaminase to the inner mitochondrial membrane. Biochim Biophys Acta. 1984 Oct 16;801(3):334-41. As opposed to the data obtained in sonicated mitochondria, the kinetics of -dependent glutaminase in 0.03% Triton X-100-treated mitochondria agreed quite well with those obtained in intact, rotenone-inhibited and metabolically active mitochondria. |
36(0,1,1,6) | Details |
| 961871 | Tannen RL, Kunin AS: Effect of on ammoniagenesis by renal mitochondria. . Am J Physiol. 1976 Jul;231(1):44-51. When rotenone is added to the medium, increased ammoniagenesis is still detected, indicating that either entry into the mitochondria and/or the activity of -dependent glutaminase are critical rate-controlling steps. |
6(0,0,1,1) | Details |
| 5530189 | Kovacevic Z, McGivan JD, Chappell JB: Conditions for activity of glutaminase in kidney mitochondria. . Biochem J. 1970 Jun;118(2):265-74. When the mitochondria were suspended in a medium containing P (i) and rotenone the rate of production of was stimulated by the addition of a substrate, e.g. |
6(0,0,0,6) | Details |
| 12662 | Tannen RL, Kunin AS: Effect of pH on production by renal mitochondria. . Am J Physiol. 1976 Dec;231(6):1631-7. Similar results were obtained with rotenone in the media, both with chronic acidosis and with acidosis of 3 h duration, indicating that increased entry and/or -dependent glutaminase (PDG) activity accounts for the increased ammoniagenesis. |
6(0,0,1,1) | Details |
| 1546970 | Nelson D, Rumsey WL, Erecinska M: catabolism by heart muscle. Biochem J. 1992 Mar 1;282 ( Pt 2):559-64. Properties of phosphate-activated glutaminase.. Rat heart homogenates catabolized in the presence of rotenone, an inhibitor of the respiratory chain. 2. |
4(0,0,0,4) | Details |
| 15535970 | Haslett MR, Pink D, Walters B, Brosnan ME: Assay and subcellular localization of dehydrogenase in rat liver. Biochim Biophys Acta. 2004 Nov 18;1675(1-3):81-6. A spectrophotometric assay for P5CDh was shown to be valid if rotenone was included in the assay to prevent reoxidation of P5CDh is enriched only in the mitochondrial fractions, as are the mitochondrial enzymes, cytochrome c reductase, oxidase, glutaminase, and ornithine aminotransferase. |
1(0,0,0,1) | Details |
| 22551 | Willis RC, Seegmiller JE: The inhibition by 6-diazo-5-oxo- of catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. The exposure of cells to DON ihibits over 95% of the glutaminase activity measured in lysates in the presence of either or |
1(0,0,0,1) | Details |
| 2690640 | Sastrasinh S, Sastrasinh M: transport in submitochondrial particles. Am J Physiol. 1989 Dec;257(6 Pt 2):F1050-8. -dependent glutaminase activity in SMP was only 0.04% of that in intact mitochondria. |
1(0,0,0,1) | Details |
| 4722898 | Crompton M, Chappell JB: Transport of and in kidney mitochondria in relation to deamidation. Biochem J. 1973 Jan;132(1):35-46. The -dependent glutaminase activity of intact mitochondria is stimulated by the provision of energy. 5. |
1(0,0,0,1) | Details |
| 6572560 | Abou-Khalil WH, Yunis AA, Abou-Khalil S: Prominent oxidation activity in mitochondria of hematopoietic tumors. Cancer Res. 1983 May;43(5):1990-3. Oxypolarographic tests showed the following. (a) Presence of a prominent glutaminase activity in erythroleukemia and chloroma mitochondria is evidenced by their active -supported respiratory state 3. (b) oxidation is mediated through a -linked reaction inhibited by rotenone. (c) Under similar conditions, mitochondria isolated from rabbit bone marrow have shown a feeble oxidation activity, while in mitochondria from rat liver the activity was not detectable and in those from rat kidney it was prominent as expected. (d) The determination of apparent Km and Vmax values for substrate-supported formation has shown 8- to 10-fold lower Km values for oxidation as compared to that of with virtually the same Vmax for each substrate in each mitochondria. |
0(0,0,0,0) | Details |