| Name | DJ 1 |
|---|---|
| Synonyms | DJ 1; DJ1; Oncogene DJ1; PARK 7; PARK7; Protein DJ 1; RNA binding protein regulatory subunit; Oncogene DJ1s… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19063952 | Ashley AK, Hanneman WH, Katoh T, Moreno JA, Pollack A, Tjalkens RB, Legare ME: Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes. Toxicol Lett. 2009 Feb 10;184(3):186-91. Epub 2008 Nov 21. Primary astrocytes isolated from DJ-1 (-/-) mice reveal a decreased nuclear localization of DJ-1 protein in response to rotenone or LPS, with a concomitant increase in mitochondrial localization of DJ-1 found only in the rotenone exposure. |
13(0,0,1,8) | Details |
| 18331584 | Liu F, Nguyen JL, Hulleman JD, Li L, Rochet JC: Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. J Neurochem. 2008 Apr 15. DJ-1 alleviated rotenone toxicity by up-regulating total intracellular |
13(0,0,1,8) | Details |
| 16624565 | Pisani A, Martella G, Tscherter A, Costa C, Mercuri NB, Bernardi G, Shen J, Calabresi P: Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase. Neurobiol Dis. 2006 Jul;23(1):54-60. Epub 2006 Apr 19. We assessed the responses of dopaminergic cells to combined and deprivation (OGD), and to the mitochondrial toxin rotenone. |
8(0,0,0,8) | Details |
| 16139213 | Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM: Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol. 2005 Sep 6;15(17):1572-7. DJ-1alpha and DJ-1beta double knockout flies are viable, fertile, and have a normal lifespan; however, they display a striking selective sensitivity to those environmental agents, including paraquat and rotenone, linked to PD in humans. |
5(0,0,0,5) | Details |
| 19647776 | Inden M, Kitamura Y, Tamaki A, Yanagida T, Shibaike T, Yamamoto A, Takata K, Yasui H, Taira T, Ariga H, Taniguchi T: Neuroprotective effect of the antiparkinsonian drug pramipexole against nigrostriatal dopaminergic degeneration in rotenone-treated mice. Neurochem Int. 2009 Dec;55(8):760-7. Epub 2009 Aug 6. To examine the neuroprotective effect of pramipexole against oxidative stress, we used a DJ-1-knockdown SH-SY5Y cell line and electron spin resonance (ESR) spectrometry. |
2(0,0,0,2) | Details |
| 18715146 | Ethell DW, Fei Q: Parkinson-linked genes and toxins that affect neuronal cell death through the Bcl-2 family. Antioxid Redox Signal. 2009 Mar;11(3):529-40. Oxidative stress induced by the neurotoxins MPTP, paraquat, maneb, and rotenone causes lipid peroxidation and protein misfolding that affects cell death through members of the Bcl-2 family. Of the familial mutations identified thus far, two of the loci encode proteins associated with ubiquitin-proteasome degradation of misfolded proteins (Parkin and Uch-L1), and two encode proteins associated with mitochondria and oxidative stress (DJ-1 and PINK1). |
1(0,0,0,1) | Details |
| 19692353 | Venderova K, Kabbach G, Abdel-Messih E, Zhang Y, Parks RJ, Imai Y, Gehrke S, Ngsee J, Lavoie MJ, Slack RS, Rao Y, Zhang Z, Lu B, Haque ME, Park DS: Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet. 2009 Nov 15;18(22):4390-404. Epub 2009 Aug 19. However, these flies were more sensitive to rotenone. |
2(0,0,0,2) | Details |
| 16239214 | Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B: Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005 Dec 30;280(52):42655-68. Epub 2005 Oct 19. C. elegans lines with these genetic changes were more vulnerable than nontransgenic nematodes to mitochondrial complex I inhibitors, including rotenone, fenperoximate, pyridaben, or stigmatellin. |
2(0,0,0,2) | Details |
| 19409963 | Caudle WM, Kitsou E, Li J, Bradner J, Zhang J: A role for a novel protein, nucleolin, in Parkinson's disease. Neurosci Lett. 2009 Jul 31;459(1):11-5. Epub 2009 May 4. Previously, in a cellular model of PD, we identified nucleolin as a protein interacting with alpha-synuclein and DJ-1, two critical proteins involved in PD pathogenesis. Furthermore, manipulation of nucleolin in an in vitro model of PD resulted in significant alterations in the generation of oxidative stress as well as proteasomal inhibition following rotenone exposure. |
1(0,0,0,1) | Details |
| 17010972 | Liang CL, Wang TT, Luby-Phelps K, German DC: Mitochondria mass is low in mouse substantia nigra neurons: implications for Parkinson's disease. Exp Neurol. 2007 Feb;203(2):370-80. Epub 2006 Sep 28. Many sporadic PD patients have a defect in mitochondria respiration, and some of the genes that cause PD are mitochondrial-related (e.g., PINK1, Parkin, DJ1). |
1(0,0,0,1) | Details |
| 18930142 | Mullett SJ, Hinkle DA: DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. Neurobiol Dis. 2009 Jan;33(1):28-36. Epub 2008 Sep 30. |
92(1,1,2,7) | Details |
| 16439141 | Betarbet R, Canet-Aviles RM, Sherer TB, Mastroberardino PG, McLendon C, Kim JH, Lund S, Na HM, Taylor G, Bence NF, Kopito R, Seo BB, Yagi T, Yagi A, Klinefelter G, Cookson MR, Greenamyre JT: Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system. Neurobiol Dis. 2006 May;22(2):404-20. Epub 2006 Jan 24. Chronic rotenone exposure in vivo caused oxidative modification of DJ-1, accumulation of alpha-synuclein, and proteasomal impairment. |
89(1,1,2,4) | Details |
| 16854843 | Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J: Identification of novel proteins associated with both alpha-synuclein and DJ-1. Mol Cell Proteomics. 2007 May;6(5):845-59. Epub 2006 Jul 18. Of those, 114 proteins displayed significant changes in the relative abundance in the complexes associated with alpha-synuclein, DJ-1, or both after rotenone treatment. |
49(0,1,3,9) | Details |
| 18377993 | Lev N, Ickowicz D, Melamed E, Offen D: Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection. Neurotoxicology. 2008 May;29(3):397-405. Epub 2008 Mar 10. The aim of this study was to elucidate the effects of the neurotoxins rotenone and that lead to intracellular reactive species (ROS) on DJ-1 expression levels and intracellular distribution. |
24(0,0,3,9) | Details |