Protein Information

Name IL 10
Synonyms B TCGF; B cell derived T cell growth factor; CSIF; Cytokine synthesis inhibitory factor; IL 10; IL10; IL10A; Interleukin 10…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
15667587 Perianayagam MC, Morena M, Jaber BL, Balakrishnan VS: Anti-oxidants reverse uraemia-induced down-regulation of mitochondrial membrane potential and interleukin-10 production. Eur J Clin Invest. 2005 Feb;35(2):148-53.

To assess the relative contribution of the NADPH oxidase and mitochondrial electron transport chain (ELT) to endotoxin (ET)-stimulated IL-10 production among monocytic cells, cells were incubated with and without a selective NADPH oxidase inhibitor, apocynin and mitochondrial ELT inhibitors, diphenyliodinium and rotenone, washed and ET-stimulated IL-10 production was measured.
41(0,1,1,11) Details
17562359 Staines DR: Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?. Med Hypotheses. 2007;69(6):1208-11. Epub 2007 Jun 11.

PACAP specifically protects against the neurotoxicity induced by rotenone as well as protecting against oxidative stress-induced apoptosis.
Involvement of the Th1 directed cytokine interferon-gamma has been demonstrated and Th2 directed cytokines such as IL-10 protect against inflammation-mediated degeneration of dopaminergic neurons in the SN.
1(0,0,0,1) Details
11710721 Sambo P, Baroni SS, Luchetti M, Paroncini P, Dusi S, Orlandini G, Gabrielli A: Oxidative stress in scleroderma: maintenance of scleroderma fibroblast phenotype by the constitutive up-regulation of reactive oxygen species generation through the NADPH oxidase complex pathway. Arthritis Rheum. 2001 Nov;44(11):2653-64.


This suppression was not seen with rotenone, a mitochondrial oxidase inhibitor, or allopurinol, a xanthine oxidase inhibitor.
0(0,0,0,0) Details