| Name | CD95 |
|---|---|
| Synonyms | ALPS1A; APT1; FAS; APO 1; APO 1 cell surface antigen; APO1; Apo 1 Fas; Apo 1 antigen… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11046005 | Torres-Roca JF, Tung JW, Greenwald DR, Brown JM, Herzenberg LA, Herzenberg LA, Katsikis PD: An early -dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. J Immunol. 2000 Nov 1;165(9):4822-30. In contrast, anti-CD95 thymocyte apoptosis is unaffected by hypoxia, indicating the existence of two forms of thymocyte apoptosis: an -dependent pathway (Dex induced) and an -independent pathway (anti-CD95 induced). |
3(0,0,0,3) | Details |
| 9989825 | Dumont A, Hehner SP, Hofmann TG, Ueffing M, Droge W, Schmitz ML: peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive species and the activation of NF-kappaB. Oncogene. 1999 Jan 21;18(3):747-57. Inhibition of the mitochondrial permeability transition by bongkrekic acid (BA), or interference with the mitochondrial electron transport system by rotenone or prevented the cytotoxic effect of H2O2. |
1(0,0,0,1) | Details |
| 8902626 | Asoh S, Mori T, Hayashi J, Ohta S: Expression of the apoptosis-mediator Fas is enhanced by dysfunctional mitochondria. J Biochem. 1996 Sep;120(3):600-7. We applied an antibody against an apoptosis mediator, Fas/APO-1/CD95, to HeLa-derived cells that completely lack mitochondrial DNA (mtDNA) or have mutant mtDNAs. Incubating the cells containing wild-type mtDNA with the respiratory inhibitors rotenone and antimycin A enhanced the content of mRNA of the Fas gene 2 to 4-fold and sensitized cells to the antibody. |
1(0,0,0,1) | Details |
| 19633536 | Li Y, Rory Goodwin C, Sang Y, Rosen EM, Laterra J, Xia S: Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. Anticancer Drugs. 2009 Oct;20(9):770-8. Moreover, the mitochondrial respiratory chain complex I inhibitor rotenone potentiated CH-11-induced apoptosis in DAOY cells. |
1(0,0,0,1) | Details |
| 10366439 | Leist M, Single B, Naumann H, Fava E, Simon B, Kuhnle S, Nicotera P: Inhibition of mitochondrial ATP generation by switches apoptosis to necrosis. Exp Cell Res. 1999 Jun 15;249(2):396-403. In contrast, depleting intracellular ATP with rotenone, an inhibitor of mitochondrial complex I mimicked the effect of NO. |
0(0,0,0,0) | Details |
| 9199966 | Katsikis PD, Garcia-Ojeda ME, Torres-Roca JF, Greenwald DR, Herzenberg LA, Herzenberg LA: HIV type 1 Tat protein enhances activation-but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals. Int Immunol. 1997 Jun;9(6):835-41. Examining the mechanisms by which Tat induces apoptosis, we found that inhibitors of reactive intermediate (ROI) generation or neutralizers of ROI, such as rotenone, a potent inhibitor of mitochondrial complex I of the respiratory chain, and 3,3,5,5-tetramethylpyrroline N-oxide (TMPO), an electron spin trap, could both enhance the spontaneous apoptosis induced by Tat. |
0(0,0,0,0) | Details |