Protein Information

Name DIABLO
Synonyms DIABLO; DIABLO S; Direct IAP binding protein with low pI; Mitochondrial Smac protein; SMAC; SMAC 3; SMAC3; Second mitochondria derived activator of caspase…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17006955 Saunders R, Szymczyk KH, Shapiro IM, Adams CS: Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. J Cell Biochem. 2007 Feb 15;100(3):703-15.

Western blot analysis indicated migration of cytochrome-c and Smac/DIABLO from mitochondria to the cytoplasm.
Inhibition of either the electron transfer chain (with antimycin a and rotenone), or the activation of a MMP transition (with bongkrekic acid) inhibited apoptosis in a dose-dependent manner.
1(0,0,0,1) Details