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Saunders R, Szymczyk KH, Shapiro IM, Adams CS: Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. J Cell Biochem. 2007 Feb 15;100(3):703-15.
Western blot analysis indicated migration of cytochrome-c and Smac/DIABLO from mitochondria to the cytoplasm. Inhibition of either the electron transfer chain (with antimycin a and rotenone), or the activation of a MMP transition (with bongkrekic acid) inhibited apoptosis in a dose-dependent manner. |
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