| Name | ALDH2 |
|---|---|
| Synonyms | ALDH class 2; ALDH 2; ALDH E2; ALDH2; ALDHI; ALDM; Aldehyde dehydrogenase 2; DHAM… |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15377279 | Kollau A, Hofer A, Russwurm M, Koesling D, Keung WM, Schmidt K, Brunner F, Mayer B: Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of Biochem J. 2005 Feb 1;385(Pt 3):769-77. Conversion of GTN into 1,2-GDN (1,2- dinitrate) and by mitochondrial ALDH2 (aldehyde dehydrogenase 2) may be an essential pathway of GTN bioactivation in blood vessels. Lack of effect of the mitochondrial poisons, rotenone and myxothiazol, suggested that reduction by components of the respiratory chain is not essential to sGC activation. |
4(0,0,0,4) | Details |
| 12604195 | Niknahad H, Siraki AG, Shuhendler A, Khan S, Teng S, Galati G, Easson E, Poon R, O'Brien PJ: Modulating carbonyl cytotoxicity in intact rat hepatocytes by inhibiting carbonyl-metabolizing enzymes. Chem Biol Interact. 2003 Feb 1;143-144:107-17. Decadienal-induced cytotoxicity was also more increased by mitochondrial ALDH2 inhibitors than acrolein and was more increased by decreasing mitochondrial NAD+ with rotenone or decreased by increasing mitochondrial NAD+ with |
31(0,1,1,1) | Details |
| 17010440 | Leiphon LJ, Picklo MJ Sr: Inhibition of detoxification in CNS mitochondria by fungicides. Neurotoxicology. 2007 Jan;28(1):143-9. Epub 2006 Sep 1. These compounds included rotenone, maneb, mancozeb, and benomyl. |
0(0,0,0,0) | Details |