Protein Information

Name Atrial natriuretic peptide
Synonyms ANF; ANP; Atrial natriuretic factor; Atrial natriuretic factor precursor; Atrial natriuretic peptide; Atrial natriuretic polypeptide; Atrionatriureticfactor; Atriopeptin…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1646057 Richards JM, Gibson IF, Martin W: Effects of hypoxia and metabolic inhibitors on production of prostacyclin and endothelium-derived relaxing factor by pig aortic endothelial cells. Br J Pharmacol. 1991 Jan;102(1):203-9.

The content of adenosine triphosphate (ATP) and basal and bradykinin-stimulated production of prostacyclin and endothelium-derived relaxing factor (EDRF) was measured in primary cultures of porcine aortic endothelial cells under normoxic (14.4% O2) and hypoxic (2.8% O2) conditions, and following treatment with rotenone and 2-deoxy glucose, which inhibit oxidative and glycolytic metabolism, respectively. 2.
Elevation of cyclic GMP content by atriopeptin II was also unaffected. 4.
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19542490 Casals G, Ros J, Sionis A, Davidson MM, Morales-Ruiz M, Jimenez W: Hypoxia induces B-type natriuretic peptide release in cell lines derived from human cardiomyocytes. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H550-5. Epub 2009 Jun 19.

Finally, the treatment of AC16 cells with the HIF-1 inhibitor rotenone in hypoxia inhibited BNP and VEGF release.
The accumulation of BNP, atrial natriuretic peptide (ANP), and vascular endothelial growth factor (VEGF) was then measured.
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11078377 Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I: Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S201-4.


In this study, we applied mitochondrial inhibitors, such as rotenone, cobalt chloride and antimycin A, which inhibit mitochondrial function at different sites of the mitochondrial respiratory chain, to cardiomyocytes.
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