| Name | D lactate dehydrogenase |
|---|---|
| Synonyms | D lactate dehydrogenase; DLD; LDHD; Lactate dehydrogenase D; Lactate dehydrogenase Ds |
| Name | rotenone |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15949980 | Atlante A, de Bari L, Valenti D, Pizzuto R, Paventi G, Passarella S: Transport and metabolism of in Jerusalem artichoke mitochondria. . Biochim Biophys Acta. 2005 Jun 1;1708(1):13-22. Epub 2005 Mar 31. It was found that: 1) can be synthesized by Jerusalem artichoke by virtue of the presence of glyoxalase II, the activity of which was measured photometrically in both isolated Jerusalem artichoke mitochondria and cytosolic fraction after the addition of S-D-lactoyl- 2) Externally added caused consumption by mitochondria, mitochondrial membrane potential increase and release, in processes that were insensitive to rotenone, but inhibited by both antimycin A and 3) was metabolized inside mitochondria by a flavoprotein, a putative D-lactate dehydrogenase, the activity of which could be measured photometrically in mitochondria treated with Triton X-100. 4) Jerusalem artichoke mitochondria can take up externally added by means of a /H (+) symporter investigated by measuring the rate of reduction of endogenous flavins. |
82(1,1,1,2) | Details |
| 11955284 | de Bari L, Atlante A, Guaragnella N, Principato G, Passarella S: transport and metabolism in rat liver mitochondria. . Biochem J. 2002 Jul 15;365(Pt 2):391-403. We found the following: (1) externally added causes uptake by mitochondria [P/O ratio (the ratio of mol of synthesized to mol of atoms reduced to water during oxidative phosphorylation)=2] and membrane potential (Delta (psi)) generation in processes that are rotenone-insensitive, but inhibited by antimycin A and and release from coupled mitochondria inhibited by alpha-cyanocinnamate, but not by phenylsuccinate; (2) the activity of the putative flavoprotein (D-lactate dehydrogenase) was detected in inside-out submitochondrial particles, but not in mitochondria and mitoplasts, as it is localized in the matrix phase of the mitochondrial inner membrane; (3) three novel separate translocators exist to mediate traffic across the mitochondrial inner membrane: the /H (+) symporter, which was investigated by measuring fluorimetrically the rate of endogenous flavin reduction, the /oxoacid antiporter (which mediates both the / and / exchanges) and / antiporter studied by monitoring photometrically the appearance of the counteranions outside mitochondria. The translocators and the D-lactate dehydrogenase could account for the removal of the toxic from cytosol, as well as for -dependent gluconeogenesis. |
1(0,0,0,1) | Details |