Protein Information

Name XIAP
Synonyms API 3; API3; Apoptosis inhibitor 3; BIRC 4; BIRC4; Baculoviral IAP repeat containing protein 4; HILP; IAP Like protein…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
17035597 Peng XH, Karna P, O'Regan RM, Liu X, Naithani R, Moriarty RM, Wood WC, Lee HY, Yang L: Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells. Mol Pharmacol. 2007 Jan;71(1):101-11. Epub 2006 Oct 11.


Increasing evidence shows that the inhibitor of apoptosis (IAP) proteins survivin and XIAP are highly expressed in tumor cells but are absent or have very low levels of expression in normal adult tissues.
2(0,0,0,2) Details
19633536 Li Y, Rory Goodwin C, Sang Y, Rosen EM, Laterra J, Xia S: Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. Anticancer Drugs. 2009 Oct;20(9):770-8.

Western blot analyses showed that the combination of CH-11+CPT induced a significant decrease in XIAP levels.
Moreover, the mitochondrial respiratory chain complex I inhibitor rotenone potentiated CH-11-induced apoptosis in DAOY cells.
1(0,0,0,1) Details