Protein Information

Name PACAP
Synonyms Caspase 2 binding protein; PACAP; HSPC190; PACAP protein; Proapoptotic caspase adaptor protein; PACAP proteins; Proapoptotic caspase adaptor proteins

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
16004991 Wang G, Qi C, Fan GH, Zhou HY, Chen SD: PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone. FEBS Lett. 2005 Jul 18;579(18):4005-11.
63(0,2,2,3) Details
17562359 Staines DR: Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides?. Med Hypotheses. 2007;69(6):1208-11. Epub 2007 Jun 11.

PACAP specifically protects against the neurotoxicity induced by rotenone as well as protecting against oxidative stress-induced apoptosis.
8(0,0,1,3) Details
16904179 Reglodi D, Lubics A, Kiss P, Lengvari I, Gaszner B, Toth G, Hegyi O, Tamas A: Effect of PACAP in 6-OHDA-induced injury of the substantia nigra in intact young and ovariectomized female rats. Neuropeptides. 2006 Aug;40(4):265-74. Epub 2006 Aug 10.

Among others, it protects dopaminergic neurons in vitro, against 6-OHDA- and rotenone-induced injury.
7(0,0,0,7) Details