Protein Information

Name nuclear respiratory factor 1
Synonyms ALPHA PAL; NRF1; Alpha palindromic binding protein; EWG; NRF 1; Nuclear respiratory factor 1; Alpha palindromic binding proteins; Nuclear respiratory factor 1s

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
19772854 Aronis A, Aharoni-Simon M, Madar Z, Tirosh O: Triacylglycerol-induced impairment in mitochondrial biogenesis and function in J774.2 and mouse peritoneal macrophage foam cells. Arch Biochem Biophys. 2009 Dec;492(1-2):74-81. Epub 2009 Sep 20.

Inhibitors of mitochondrial complexes, rotenone (0.1 microM) and myxothiazol (25 nM), protected the viability in TG-loaded macrophages.
The exposure to TG caused downregulation of PPARgamma coactivator (PGC)-1alpha and nuclear respiratory factor (NRF)-1.		 1(0,0,0,1) Details