Protein Information

Name glucokinase
Synonyms GCK; HK4; GCK; GK; GLK; Glucokinase; HHF 3; HHF3…

Compound Information

Name rotenone
CAS

Reference List

PubMed Abstract RScore(About this table)
1531411 Dagani F, Ferrari R, Tosca P, Canevari L: Effects of calcium antagonists on glycolysis of rat brain synaptosomes. Biochem Pharmacol. 1992 Jan 22;43(2):371-4.

The effects of calcium antagonists nimodipine, nicardipine and flunarizine on lactate production and specific activities of some enzymes regulating glycolytic flux have been evaluated in synaptosomes isolated from rat whole brain and submitted to in vitro chemical hypoxia induced by rotenone, an inhibitor of mitochondrial respiration.
The following enzymes have been tested; hexokinase (ATP: D-hexose-6-phosphotransferase, EC2.7.1.1), phosphofructokinase (ATP: D-fructose-6-phosphate 1-phosphotransferase, EC 2.7.1.11) and pyruvate kinase (ATP: pyruvate 2-O-phosphotransferase, EC 2.7.1.40).
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166791 Azzar G, Berthillier G, Got R: [Phylogenetic study of hepatic microsomal glucokinases] Comp Biochem Physiol B. 1975 Jun 15;51(2):187-92.

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17827405 Garcia-Fernandez M, Ortega-Saenz P, Castellano A, Lopez-Barneo J: Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes. 2007 Dec;56(12):2893-900. Epub 2007 Sep 7.


Rotenone, a drug that occludes glomus cell sensitivity to hypoxia, did not abolish responsiveness to low glucose.
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